I am 72 year old male.
eGFR is 93
From creatinine test (Labcorp)
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LaraPo
#7
I envy your labs! My eGFR is 72 (have transplanted kidney). I’m also on plant based diet with occasional fish, no alcohol, no added sugars or salt. 14 years on Rapa.
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Beth
#8
EGFR 101 (I’ve never even looked at this nor known what it was!!)
This was from prior to starting rapa in march
58
Female
Wfpb
0-3 glasses of wine per month
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I am male, just turned 60. Rapa user.
eGFR is one of those tests where as long as you’re in the “normal” range the doctor generally doesn’t call any attention to it. Per LabCorp, “normal” is a value over 60. I have online results from 2012 when my value was 89. Since then I’ve had values as low as 65 but in the past five years they’ve been in the mid 70s. Most recent was 76. Definitely a decreasing trend over a 12 year period. Now I’m thinking I should be more concerned about that than I have been.
Using the website @adssx supplied, my GFR category is “mildly decreased” (CKD-EPI creatinine equation of 80 mL/min/1.73m2).
While I don’t think this is a flashing red light right now, I certainly don’t want the downward trend to continue, and if possible I’d want to reverse it. How to achieve this is the next question…
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adssx
#10
SGLT2 inhibitors are the gold standard for this. Then renin-angiotensin-system (RAS)-acting agents (such as sartans like telmisartan). Unlikely to reverse the decline, but they significantly slow it down. (Also probably GLP1-RAs, but we need more trials.)
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adssx
#11
@Dexter_Scott, here are the latest international guidelines on CKD: Optimal Blood Pressure we Should Target? Systolic Under 110 or 100? - #392 by adssx
Easy to understand and comprehensive, well worth a read.
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There may be some relevant information here:
Dr. Hashmi
Some specific recommendations at 5min45sec
[Understanding eGFR and ways to improve.]
I am considering testing my cystatin C as well. But need to educate myself a bit more.
Regular physicians really don’t counsel people as to how to optimize, they are just making sure you are within the reference ranges.
I take it that eGFR did not change with rapa use?
Do you have a preferred diet? normal omni, meat/fat heavy keto, lacto veg, pesco veg etc? TRE or fasting?
Also, do you use creatine? I understand that it will raise creatinine and therefore lower eGFR giving a sort of false picture of kidney status
I read that entire 900-post thread on canagliflozin and I wasn’t sure it was necessary for me given that my a1c results are 5.0 to 5.1, and my HOMA IR scores show that I’m not “pre-diabetic”. However, I did see that study showing that they are at least somewhat cardioprotective for non-diabetics, and that plus protection against CKD suggests that taking them might be well worthwhile.
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I take it that eGFR did not change with rapa use?
Not observably, although I haven’t been taking rapa for very long (two years or so) and if the effect was that it “slowed the decline” then it would be hard to know for sure that it was rapa doing that.
Do you have a preferred diet? normal omni, meat/fat heavy keto, lacto veg, pesco veg etc? TRE or fasting?
My diet is “natural foods” (avoid ultraprocessed, mostly make my food at home), avoid seed oils / fried foods, eat fish several times a week, probably not enough veg but I eat quite a lot of strawberries and blueberries.
I used to eat a lot of yogurt but I had to quit because it was giving me EoE (not formally diagnosed but that’s my very strong suspicion). Haven’t had any swallowing issues since I quit. My only dairy now is cheese which doesn’t give me any issues.
I do 16/8 intermittent fast because that’s very easy. Nothing between 8pm and lunch the next day. When I stay on that, there is a definite decrease in resting heart rate.
Addendum: I already don’t drink, don’t smoke, am not obese, have satisfactory blood pressure, and am not pre-diabetic. All I could do, per Dr. Hashmi’s advice, is eat more plants and less meat.
adssx
#15
It’s not “somewhat cardioprotective”; it is cardioprotective and renoprotective. They are approved all around the world in non-diabetic people for heart failure and kidney disease.
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I eat yogurt every morning as part of my breakfast. What is EoE?
EoE = eosinophilic esophagitis. It is inflammation of the esophagus that causes the esophagus to become narrower. You have trouble swallowing (feels like the food doesn’t go “all the way down” but is stuck just above the stomach). This leads to a lot of saliva production and frequently you barf up the food that is stuck. Common triggers are dairy, gluten, and eggs. In my case, I haven’t yet had an official diagnosis (which requires a biopsy) but not eating dairy has made the problem go away.
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Yes, if we’re going to post numbers, everybody at least include the creatinine value, cystatin c (if tested), and either weight, height, gender, and age at the time of testing or the equation used to calc the result.
My numbers range from 84 to 118!
Last time I tested cystatin C: 2/2/2024
Cystatin C: 0.85
Creatinine: 1.09
Weight: 175 lbs
Height: 72in
Age:47
eGFR (LabCorp): 84
National Kidney Foundation Calculator surface area adjusted:
eGFR CKD-EPI creatinine (2021): 98
eGFR CKD-EPI creatinine-cystatin (2021): 112
eGFR CKD-EPI cystatin C (2012): 118
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Alani
#19
Egrf 85
Age 73
Raps 8mg/wk continuous 14wkks
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Age 49 Male
12-14 mg of Rapamycin per week (4 mg + GFJ) + 500 mg Metformin daily
I eat a varied omnivore diet. I try to eat a pesco Mediterranean diet, but eat too much pizza…
Thank goodness for Acarbose. 
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Tim
#21
72 is great for a transplant. May it serve you long and well.
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Tim
#22
The standard renal diet is low sodium, potassium, phosphorous, and protein. Little or no alcohol.
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My creatinine and Cystatin-C levels move around quite a bit depending on how much I am drinking (which can be a lot) and how much Sodium and Potassium I am supplementing (which can be a lot).
What I think is happening is that the kidneys have a standard function available and prioritise different tasks in various ways. If you increase the amount of Potassium or Sodium to be excreted that takes a priority over creatinine or Cystatin-C processing. (it may for example be a demand on ATP for this in some way). Hence the potential kidney function itself is not changing, but the biomarkers are.
Other biomarkers I look at for kidney function are Urea and Urate. Urate, however, varies a lot anyway.
At the moment I am trying to get an ideal balance between cation supplementation and kidney markers. This is so I can supplement with a high level of citrate, but have good results on the kidney biomarkers.
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Are you on rapamycin? It should help with your inflammation.
Tim
#25
After an acute kidney injury at age 70, my GFR pegged at 16 for eight or nine months. My nephs told me to prepare myself for dialysis. I told them, “No way. I’d rather die.” But then, quite unexpectedly, my GFR jumped to 24. That was seven years ago. It is now around 40. And I am not unique. .
If the cause of CKD is hypertension, then the progression of the disease will be arrested or reversed in about five percent of cases. Lucky me. Of course, I contributed to my own cause by strictly adhering to the renal diet. I’m now taking SS-31, which I hope will have an even more salubrious effect on the kidneys.
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