#21

Don’t know enough but your blood test might be different from what you want in your micro biome

See et this

#22

Anyone have any experience on whether the peptide BPC157 might help ALP with fighting leaky gut?

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#23

You’re sure about this? My recent result was 40 and flagged as LOW. I read deficiencies in magnesium and/or zinc could cause that, even though I consume plenty of both.

#24

I’m not a doctor. I read about this in Michael Lustgarten’s excellent book “Microbial Burden and what you can do about it”. I’m sure the microbial burden is not the only thing that affects AP. Google lists protein deficiency and a couple diseases as well. If these things are ruled out then that leaves really good news about your microbial burden.

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#26

Update, I asked him and this was his response

“< 48 for ALP is associated with lowest all-cause mortality risk, so you’re likely good there

Liver enzymes and risk of all-cause mortality in general populations: a systematic review and meta-analysis - PubMed “

So thank you for bringing it to my attention @Bicep . I’m not so worried anymore

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#27

Have you tried supplementing with these? It looks like one of the safest approaches right now in terms of longevity.

I was hoping someone had tried with available current IALP:

#28

Unfortunately, it appears that Synthetic Biologics (now Theriva Biologics) has abandoned further work on this asse. It’s not currently listed in their pipeline, and a press release from November mentions " lower expenses related to our Phase 1a clinical trial of SYN-020 which has completed".

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#29

An update to this thread. This article from 2024 brings forward the theoretical framework that challenges the mainstream theory of ageing. For those not familiar with the term “smurf” in ageing - they have found that when flies are fed with food that contains a blue dye, then 2–3 days before the death, the fly turns blue. Therefore, the name smurf. This smurf phenotype is due to the breakdown of the intestinal barrier, a leaky gut. They don’t say that “leaky gut” is causative of an impeding death, but there is a very strong correlation between the smurf phenotype and an imminent death. Now they try to find signals that precede the smurf phenotype.

"It is demonstrated that the smurf phenotype is a harbinger of death across species, allowing for the identification of individuals about to die from natural conditions 2–3 days prior to death. As time passes for a non-Smurf, its gene expression becomes noisier until it reaches a point—an hypothetical “Smurf Transition Point” yet to be characterized—at which individuals undergo an abrupt modification of the transcriptome, reminiscent of the “transcription hallmarks of ageing” leading to a general stereotyped collapse "

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