Pat25
#33
Why did you stop?
Yes Prostaphane seemed reliable. Given how many interesting studies you tend to dig up, I’m sure you have seen the studies with it.
My concern back then was the titanium dioxide in it. Albeit of course it only has a very low concentration of titanium dioxide, but I took around 4+ tabs per day, and I tend to be (perhaps overly?) cautious. (Not sure if titanium dioxide is still an ingredient.) Plus: at the time I had visible inflammation and I just didn’t notice any effects, albeit I used higher doses for years. It made me question if it was still ‘active’, and wonder about temperature fluctuations for days during shipment. All in all, I didn’t find the cost worth it anymore.
2 Likes
adssx
#34
Good point. It was banned in Europe but:
While the new EFSA Opinion, published on 6 May 2021, does not conclude that E171 is a definite risk to health, it does not rule out that possibility either. In particular, EFSA does not rule out genotoxicity concerns, meaning that there is a possibility that the use of titanium dioxide as food additive might cause DNA or chromosomal damage. In the EU, the fact that the safety of a food additive cannot be confirmed is sufficient to warrant a ban.
Titanium dioxide will still be authorised for use in medicinal products until other safe alternatives are found. This is to avoid causing shortages of medicinal products that could negatively impact public health or animal health and welfare. This approach is supported by the European Medicines Agency (EMA) analysis on the use of titanium dioxide in medicines published on 8 October 2021. The Commission, together with EMA, will re-evaluate the situation in the future." ( https://ec.europa.eu/newsroom/sante/items/732079/en )
The reseller says: “Other ingredients:
Vegetable Cellulose Capsule Shell (HPMC, colourant: copper complex of chlorophyllins), Maltodextrin, Acacia Gum, Magnesium Stearate Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.”:
So I assume there’s no titanium dioxide anymore. I’ll email them, though, to confirm.
How much does sulforaphane lower hsCRP? This paper found no improvement: Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease 2019
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If you Google “Sulfodyne”, you will find several other companies, at least here in France, that have licensed Sulfodyne from Ingood by Olga. For exemple:
Dynveo
Nutrixeal
Phytobioeco
HSN
The one by Dynveo seems to be significantly cheaper (https://www.dynveo.fr/sulforaphane.html)
What I find odd, is that Prostaphane is squarely marketed towards prostate problems of older men, and not longevity or health in general. I didn’t even knwo it was efficient in regars to urinary problems and so on, I’m 57 but have no such problems.
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cl-user
#36
That paper is interesting. They even compare Sulfodyne to rapamycin:
From Multiple Mechanisms of Action of Sulfodyne®, a Natural Antioxidant, against Pathogenic Effects of SARS-CoV-2 Infection
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Pat25
#37
Indeed, but frankly I didn’t go by hsCRP, as my hsCRP levels in repeated blood tests had in fact been decent. But at the time I was still diagnosed with a serious disease, and still had visible inflammation/discomfort. There was some interesting research about sulforaphane and that particular disease. As such I used high doses of Prostaphane daily (and after ~a year I added another sulforaphane supplement). But clearly this is just a n=1/personal experience/observation.
adssx
#38
Dynveo costs €22.90 for 60 pills of 100 mg, so €0.38 per 100-mg pill. Prostaphane costs €78.90 for 90 pills of 200 mg so €0.44 per 100-mg pill, 16% more expensive! I’ve just emailed Ingood by Olga to confirm that these are the same products…
Interesting! Another paper found something similar: Sulforaphane inhibits mTOR in an NRF2-independent manner
So should you pulse it as well? 
@DrFraser @John_Hemming what do you think?
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Jay
#39
I must have missed it somehow. So, what is the noticeable and positive effect?
For me, I notice a mild caffeine like buzz without the jitteryness. It was much more pronounced the first few months and it’s hard for me to notice at all now.
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Jay
#41
BeatTheOdds, on the erucic acid content concern I compiled two tables using ChatGPT. The first table is per 1 gram of broccoli seeds. The second table is per 1 gram sprouted seeds. Beware of ChatGPT because it commonly makes mistakes!
In table 1 the glucoraphanin and erucic acid content varies significantly among broccoli seed cultivars. Below is an updated table summarizing the available data on glucosinolates and erucic acid levels, as well as the potential health risks associated with erucic acid:
| Cultivar |
Erucic Acid Range (mg/g) |
Glucoraphanin Content (mg/g) |
Erucic Acid Risk |
| Green Duke |
25–50 |
3–8 |
Moderate to high; excessive intake can harm cardiovascular health and liver【207】【208】. |
| Marathon |
30–48 |
2–6 |
Potentially harmful with prolonged high doses, especially in children and pregnant women【207】【208】. |
| Emperor |
28–52 |
4–10 |
High erucic acid poses risks, but occasional intake is generally considered safe【207】【208】. |
| BSR and NT Radish* |
16–19 |
N/A |
Lowest erucic acid levels; minimal risk compared to other cultivars【207】. |
| Standard Sprouting Broccoli |
20–45 |
5–12 |
May contribute to sulforaphane production; manage intake for sensitive individuals【207】【208】. |
Table 2 is per 1 gram sprouted broccoli seeds
| Cultivar |
Erucic Acid Range (mg/g) (3-Day Sprouts) |
Glucoraphanin Content (mg/g) (3-Day Sprouts) |
Erucic Acid Risk |
| Green Duke |
5–12 |
10–25 |
Reduced erucic acid; safe for consumption in moderate quantities. |
| Marathon |
4–10 |
8–22 |
Significantly lower erucic acid; suitable for human diets. |
| Emperor |
6–14 |
12–28 |
Moderate levels; safe for consumption when balanced with other foods. |
| Low-erucic hybrids |
<5 |
15–30 |
Negligible erucic acid; ideal for dietary or supplement purposes. |
| Standard Broccoli Sprouts |
7–15 |
18–35 |
Low erucic acid; excellent source of glucoraphanin for sulforaphane production. |
3 Likes
Thiago
#42
I eat almost every day Broccoli Sprouts take a week to sprout them. I eat close to 50G daily. I just like the taste. I remember they did some studies with Broccoli Sprouts and I followed the dose. I will try to find it
I agree, the taste of broccoli sprouts when eaten in a salad or steamed as part of a meal can be very nice. But when blended, the taste is not pleasant and a ruins the experience. Blending germinated seeds is much more palatable for me. I saw a podacst with Dr. Jed Fahey, and he mentioned the seeds contain a decent amount of glucoraphanin. I’m pretty sure it was this one.
2 Likes
mccoy
#44
That’s the site I visited, they mail from UK, 12 € shipping to Italy unless it’s an order > 120 €. Of course, I may decide to order 4 boxes at 140 € with free shipping.
This makes the domestic product more appealing.
2 Likes
Ulf
#45
I wonder why Rhonda Patrick is only taking two caps of Prostaphane = 20 mg sulphoraphanes daily, since the noted studies on benefits from sprouts were based on doses of 40 - 60 mg.
In any case, I suspect pulsed use may be called for, given indications that constant NRF2 activation may be negative.
adssx
#46
Do you have sources confirming that NRF2 activation is negative?
Sulforaphane’s half life seems to be 2 to 3 hours. That’s short, so if you just take it in the morning, by the next morning about 10 half-lives passed, so do you really need to pulse it more than that?
4 Likes
Ulf
#47
I believe you are correct. I jumped to a conclusion too fast. Indeed, the short half-life of sulforaphanes should mean a pulsatile not constant NRF2 activation. I appreciate your clarification!
Under ordinary circumstances NRF2 has a half life of only ca 20 minutes. However, in cells exposed to NRF2 activating substances I understand that NRF2 has a half-life of about ten times more, ca 200 minutes. This means about seven half lives after 24 hours, with a concentration of less than 1% of the peak. .I am not absolutely sure I feel a small uncertainty, but I believe this is low enough to consider NRF2 levels to have returned to baseline or near baseline level i.e. meeting the definition of not constantly activating NRF2 dependent pathways.
1 Like
JuanDaw
#49
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Bicep
#50
It varies by variety. Great. I don’t even know mine. I got tired of sprouting and just gave up. Now it looks like I can just grind and throw the seeds in a smoothie?
Not completely sure they did that right because the water will weigh quite a bit, making the sulforaphane look smaller in the sprouts.
Pat25
#51
I thought broccoli sprouts have higher myrosinase activity than seeds, and myrosinase as mentioned is needed for converting glucoraphanin into sulforaphane - but I can’t find any research that supports that notion I believed to have read earlier… Can anyone else?
JuanDaw
#52
I used to grind the seeds, then mix it with wasabi and soy sauce. I used it as dip for cold cuts, or some other snack (sardines, carrot sticks). I stopped because of fear of the erucic acid content of the broccoli seeds. I intend. to resume, because further reading shows the erucic acid content of broccoli seeds is tolerable. Will post the reading material after I have retraced my steps. Was searching, and found the material this morning.
True wasabi has myrosinase. Even the commercial product passed off as Japanese wasabi has myrosinase, because it is made from horseradish, and/or mustard seeds.
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