FOXO4-DRI is an obvious one for me. It’s a selective senolytic which has had some biohacker interest for some time now: Experiences with FOXO4-DRI | FOXO4-DRI
It’s strange how I could find no mention of it on this site.
I had ChatGPT help me out with this write-up on 2-DG but the facts are solid:
Recently, while exploring the topic of potential life-extension substances, the AI ChatGPT mentioned 2-DG (2-Deoxy-D-glucose). This piqued my interest and led me to dig a little deeper into this compound. However, I discovered that despite its potential, it possesses cardiotoxic properties which make it a less viable option for life extension.
It’s been approved as an emergency adjunct therapy for COVID-19 in India, despite its known cardiotoxicity. This highlights its unique properties and potential therapeutic applications.
Functionally, 2-DG is a glycolysis inhibitor. For reasons not entirely understood, it appears to inhibit cell growth, acting as a caloric restriction mimetic. This intriguing property slows the heart rate and increases resistance to stress and toxins. Consequently, it has gained attention for potential applications in treating tumors.
The topic of anti-aging is a rapidly evolving field. To put things into perspective, a 2006 article in Scientific American referred to 2-DG as the most promising anti-aging drug. This was at a time when resveratrol and growth hormones were the talk of the town.
While 2-DG is indeed intriguing, its cardiotoxicity presents a significant hurdle for its use in life-extension studies. Interestingly, although it didn’t extend the maximum lifespan of mice in experiments, it reduced mortality in the first half of their lifespan without shortening their overall lifespan.
In conclusion, while 2-DG may not be the key to life extension we might hope for due to its cardiotoxicity, its unique properties and potential therapeutic uses continue to make it a topic of interest in scientific circles.
