#171

FANTASTIC! It’ll settle the debate once and for all regarding deprenyl, sildenafil, and GlyNAC (hopefully in a positive way!).

See you in May 2028 for the results…

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#172

Finally, Deprenyl is being dusted off the shelves. I hope they dose it correctly in the ITP because I could see it because bad at high doses and good at low doses.

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Anyone taking Selegiline / Deprenyl For Longevity?
#173

What’s weird is that I asked the Hungarian team behind all the previous deprenyl research and they were not even aware that it was going to be tested in the ITP… (they didn’t seem to be interested in the ITP either…)

The dose will be 5 ppm so 0.83 mg/kg/day. Starting age still TBD. The best results in the literature (mostly coming from that weird Hungarian lab) were obtained at 0.25 mg/kg three times per week but subcutaneously (source). According to ChatGPT and Perplexity, 0.25 mg sc ~ 2 mg oral. So 0.25 mg/kg 3x/week ~ 0.86 mg/kg/day. Exactly what the ITP chose! :pray:

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#174

Yesss, Live long and prosper. See you in 2028.

image

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#175

Honestly, I’d rather get the results in 2029 or 2030. :wink:

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#176

As a reminder, I sponsored selegiline / deprenyl on worms and it failed at 50 µM: Ora Biomedical Million Molecule Challenge Results - #155 by adssx

Is that too high? What would be the equivalent of 0.83 mg/kg/day in mice in C. elegans?

#177

What would the human dose equivalent be of 0.86mk/kg per day? Forgive my inability to know how to convert rat doses.

#178

Perplexity tells me about 5 mg/day: https://www.perplexity.ai/search/what-is-the-human-dose-equival-l6.d9zFKTYOWjtnS01_IaQ#0

Which is a lot. That’s the Parkinson’s dose. And there’s zero evidence that Parkinson’s patients on selegiline live longer or have any improvements other than symptomatic. People who use selegiline for “longevity” take about 1 mg/day (or 5 mg/week by cutting the 5 mg pill in four to use 1.25 mg/day, 4 days per week).

I wrote this article on Selegiline: Selegiline - Longevity Wiki

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#179

Great article. I occasionally check out Longevity Wiki and didn’t realize you wrote for it.

I agree that 5mg daily seems to be high for longevity. I have been taking 1.25mg per day on and off for around 7 years maybe, ever since I read about it in Life Extension magazine. I’m very interested in what more research ends up telling us here.

#180

I only wrote that article, any one can write anything btw. And it seems that the project is dead.

Anyway, after writing this article I became less convinced about selegiline. Hopefully I’m wrong. Time will tell. I’ll wait to see the ITP results (or anything else convincing) before trying it…

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#181

I have to say it doesn’t look too compelling to me after reading it either. Might have a small benefit but I don’t think it will be anywhere close to Rapamycin or Acarbose level.

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#182

Yes, its rare that you see old research dusted off and restarted… seems worthwhile given what we know: Deprenyl - Anti-Aging Drug Proven Effective in Dogs

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#183

Stoked to see glynac especially since they’ve already done glycine alone

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#184

I have a feeling we are going to see a really good result here, as long as they use a high enough dose.

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#185

I hope they are measuring such that we can rule out my hypothesis that the effect is just from NAC making the food taste bad resulting in caloric restriction

#187

This 1997 study is probably the strongest evidence
Influence of selegiline and lipoic acid on the life expectancy of immunosuppressed mice - PubMed (nih.gov)

#188

I have a feeling that we will see similar results to what we saw with astaxanthin, i.e. male median lifespan +12%, male maximum lifespan +6% (not statisticaly significant).

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#189

I would like to test Harmine and GLP-1 as antagonists for increased insulin production/ potentially increased Beta Cell regeneration. There was a comment above that the ITP does not test injectables. Rybelsus is a semaglutide in pill form – perhaps that can be used?
Would also like to test Berberine.

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#190

Oral semaglutide has a super low absorption, that’s why it’s not tested. We need better oral GLP-1RAs and the ITP will test them.

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#191

Agree we need better oral GLP meds. But to compensate for the poor absorption, Rybelsus pills are dosed far higher than injectables, with the 7 and 14 mg pills supposedly comparable to the two most often prescribed doses of the injectable semaglutide.

1 Like