Somewhat obscure, but there seems to be relevant research that combining glycine with low dose aspirin mitigates gastric distress.
Acetylsalicylic Acid Tablets with Glycine Improve Long-Term Tolerability in Antiplatelet Drug Therapy: Results of a Noninterventional Trial
https://www.researchgate.net/publication/8555018_Acetylsalicylic_Acid_Tablets_with_Glycine_Improve_Long-Term_Tolerability_in_Antiplatelet_Drug_Therapy_Results_of_a_Noninterventional_Trial
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Interesting. But you take Rapamycin?
The sleep thing I’ve heard, but I always take my aspirin in the morning and I’ve never noticed any problems from it.
As a general principle I wish to keep the body functioning normally apart from the age based deterioration. Therefore I take Rapamycin intermittently to reverse some of the age based deterioration.