#21

If you are on a blood thinner, risk profile increase for IC? my mom is taking Eliquis.

#22

Eliquis is a contraindication for Aspirin or any other blood thinners, unless recommended by your momā€™s doctor for some reason.

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#23

Yeah, my mom had a couple of PE so she is a lifer. I wonder if I am genetically exposed. I have been taking aspirin on and off for that reason.

#24

Well sh*t. I guess Iā€™m off aspirin again (for the 20th time). Thanks.

1 Like
#25

Cardiologists still recommend Aspirin 81 mg every other day if the patient has risk factors: elevated calcium score, hypertension, prediabetes or diabetes. All depends on the individual patient. Young and healthy should not take Aspirin as a primary prevention.

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#26

https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00393-5/abstract

No significant differences were observed in 5-year disease-free survival or overall survival between the aspirin and placebo groups, with hazard ratios (HRs) of 0Ā·91 (95% CI 0Ā·73ā€“1Ā·13) for disease-free survival and 0Ā·75 (0Ā·53ā€“1Ā·07) for overall survival.

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#27

@John_Hemming Nice find. Interesting information.

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#28

Ginger is a cox-1 inhibitor and sometimes recommended as also working like aspirin, i.e. anti inflammation, blood thinning, so I wonder why it is not mentioned here. No good studies? Anybody know?

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#29

Like all supplements, herbs etc - itā€™s a question of the dose and effectiveness

If we eat ginger, does it have to be raw, or is cooked ok? And how much do we need to consume? Letā€™s say itā€™s 10 grams - is that the raw weight or cooked weight?

I can also buy ginger supplements. I have a Jarrow bottle here, which contains 500 mg per pill. However, I donā€™t really know that the content is accurate. Most studies looking at supplements find that they arenā€™t dosed very accurately. I assume ginger is cheap, available and simple enough to extract that this would be accurate. The bottle says that Jarrow uses a natural drying process, rather than heat extraction, which makes it better, somehow. So maybe this ginger is good, but others are bad, or maybe Jarrow is lying - after all, the statement has a little Asterix and says it isnā€™t verified by the FDA.

Meanwhile, 80mg of aspirin is 80mg of aspirin. Itā€™s properly manufactured and properly studied. So for me, itā€™s a very simple choice.

As to the whole thread topic, I think whether to take it or not simply depends on whether you think you have higher risk of bleeding or higher risk of coagulation. If youā€™re at high risk of MI due to ASCVD, aspirin makes sense. If youā€™re not, then it probably doesnā€™t.

What I also find interesting is that aspirin is also strongly linked to lower risk of colon cancer, so I take it for that purpose too.

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#30

Your comment is implicitly based on that ginger works like aspirin, so you focus on how to reliably dose, but is it really well established that ginger and aspirin are so similar in both, desired and undesired effects???
Basically, what you claim here is that ginger should be avoided(!), because it is like eating aspirin without knowing whether I may eat way too much.

#31

That isnā€™t what I said at all.

Iā€™m saying: why care about ginger having functions like aspirin when aspirin already exists?

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#32

Because ginger is supposed to be a healthy food like many others, and it is a nice invigorating tea, and it may have other benifits that aspirin does not have and so on. So therefore, I am interested in what is actually well known about this. Your position seems to be, effectively, certainly in this case, to not eat healthy food as soon as there is a drug that works somewhat similar. Now that is a little silly, no??? I mean, you could do this with any food, say look at the amino acids and so on in whatever reasonably healthy food and go ā€œoh no, I can have all this in form of supplements and drugs that I then know the precise mg amounts.ā€

Look, perhaps the misunderstanding is this, I already like to have ginger, you see, I like it, and already eat it. So, I think I may be fine without aspirin, also regarding precise doses, because why do I need to take exactly 54.6 mg when mr Sinclair eats 81 mg, and Brian Johnson maybe 17.6???

#33

Sorry, I canā€™t tell whether this is language barrier, trolling or youā€™re hallucinating. At no point did I say that you should not eat healthy food. I am disengaging further conversation with you.

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#34

just answer the question asked instead of preaching your obsessions. I asked for good information on how much ginger is like aspirin, so that those of us who already like ginger, many of us, as we like healthy food, can judge better whether we need to bother with aspirin, or perhaps, if we fear the bad effects for older people, eat less ginger. You wrote a lot of words helping none.

#35

What does ChatGPT say (accepting it may be wrong)

Ginger (Zingiber officinale) has been studied for its COX-1 inhibitory effects, but it is generally less potent than aspirin. Hereā€™s a comparison:

1. COX-1 Inhibition Potency

  • Aspirin (Acetylsalicylic Acid)
    • Strong irreversible inhibitor of COX-1 and COX-2.
    • Acetylates the enzyme, preventing prostaglandin synthesis.
    • Effective at reducing pain, inflammation, and blood clot formation.
  • Ginger (Gingerols, Shogaols, and Paradols)
    • Moderately inhibits COX-1 and COX-2, but in a reversible manner.
    • Does not completely block prostaglandin production like aspirin.
    • Anti-inflammatory effects are weaker compared to aspirin.

2. Blood Thinning & Gastrointestinal Effects

  • Aspirin significantly reduces platelet aggregation, increasing bleeding risk and causing gastrointestinal irritation (due to COX-1 inhibition in the stomach lining).
  • Ginger has mild antiplatelet effects but is less likely to cause stomach irritation.

3. Effectiveness in Pain & Inflammation

  • Aspirin is highly effective for headaches, arthritis, and cardiovascular protection.
  • Ginger has some pain-relief benefits (especially in arthritis) but is generally weaker and slower-acting.

Conclusion

Ginger has some COX-1 inhibitory activity, but it is not as strong or as direct as aspirin. However, it is a safer alternative for those who need mild anti-inflammatory benefits without the gastrointestinal risks of aspirin.

4 Likes
#36

Speaking personally I do not wish to block prostaglandin production. I am happy to eat ginger.

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#37

So ginger is actually better than aspirin; not surprised. That it is weaker, well, how does chatgpt know how much we eat, regardless aspirin or ginger. The dose makes the poison.

#38

Why is it ā€œbetterā€ than aspirin?

I donā€™t personally want to block prostaglandin production hence I avoid aspirin.

1 Like
#39

Well you answered your own question. I agree with your personal choice. We want to facilitate longevity, not kill pain. If I want to kill pain, I surely do not take aspirin either. There are better options for different pains, say rheumatic versus headache.

ā€œprostaglandin, any of a group of naturally occurring lipid compounds that act as chemical messengers, having diverse functions and effects in humans and other animals. Prostaglandins are powerful substances that serve to regulate essential physiological processes and that mediate inflammatory and immune responses. Their role as chemical messengers ā€¦ā€

Why would one want to interfere with this so radically if interested in longevity? Moderation is the way. Ginger it is, not aspirin.

1 Like
#40

Ok, letā€™s make this all about ME!!!

Iā€™d like to find out what you all would do if you were in my position.

I have a bad family history of heart disease, I have high Lp(a), and a decade ago my CAC was almost 500ā€¦ so Iā€™m at risk.

For many years Iā€™ve been taking a baby aspirin m/w/f. Recently I was told if one is at risk for an event, they should take it daily, so I started.

But, Iā€™m petite and historically sensitive to things and if something can go wrong it will, so Iā€™m also nervous about bleeding.

In my shoes, would you take baby aspirin (I assume that answer is yes) and how often?

And, as someone who loves ginger, is the bleeding risk cumulative, meaning should I skip baby aspirin on a heavy ginger day (I am thinking it is not cumulative, but I want to be thorough by asking!).

And is there any non scientific routine you can think of for me to eat a certain amount of ginger (or take a supplement if that is better/more concentrated) to reduce the baby aspirin to some extent only to reduce risk of bleeding? For example, well, if you consume x amount of ginger, then you can probably stick to baby aspirin 3x per week, etc

Or at my risk level, would you say donā€™t mess around and just take it daily

All opinions are very welcomed!!!