#21

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#22

I love MDPI, it’s simply the best publisher.

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#23

Two things to consider … but yes, have plenty of experience with both acute and chronic management.
#1 We see these people return to the ER frequently with their various issues related
#2 I don’t only work in the ER, I’m boarded in Family Medicine and in Anti-Aging and Regenerative Medicine, Generalist EM (in Australia) so I provide primary care to my private patients, and actually care for several individuals who believe they have long Covid.

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#24

Singapore “encourages” everyone to get a 2024 booster: Health Appointment System | Same-day doctor appointments at over 800 clinics

Other countries I checked (France, UK, Japan, Hong Kong, Australia, and UAE) only recommend it to people above a certain age (50 or 65yo) or immunocompromised. I couldn’t find any clear guidelines in Canada.

So I’ll wait for more data to come out and just get my flu jab :slight_smile:

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#25

Soon I’ll be a good boy, after @RapAdmin has worked his magic on me. :wink:

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#26

I’m just a Respiratory Therapist fwiw but I believe (as does my doctor) that I had long covid from being required to work back to back 12 hour shifts while positive and symptomatic. I was formerly someone you’d call (covid) vaccine hesitant for myself. Three different people I respect in the medical field mentioned the covid vaccine helping them with long covid so after it dragging on for 6 months I took Pfizer Comirnaty shot and 1 week later woke up completely fine. I got covid again within a month after decannulating a patient who tested positive the next day and it was very mild. I’m now leaning toward getting the vaccine regularly as long as I’m in this line of work. I have no problem with the recommendations honestly only mandates.

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#27

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Absolute victory.

They encourage it, just like LKY encouraged the Singaporean airlines to get back to work. :joy:

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#28

I came here to ask if you would alter your rapa schedule based on getting the updated vax.

I had my 6mg rapa yesterday and I just signed up to get the shot on Wed. Should I skip my next dose on Sat, or is it not relevant?

My reason for my timing is I’m going to a family wedding in LA in two weeks where cases are high. I haven’t had covid yet *knocks on wood. And then I go to NYC in Nov.

I realize most people experience as a cold, but it’s certainly not everyone. Just this summer, a handful of friends in my tiny neighborhood who got it said it was the sickest they’ve ever been. Unrelated, my cousin is still having breathing problems after her covid in March.

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#29

What do you think from the rapamycin research on vaccines and older populations?

Some recent research on vaccines and elderly… shows vaccinated older groups, granted mice, most of them died even if vaccinated when infected. At best only 25% vaccinated got any benefit.

Those older mice on rapamyacin and vaccinated. All the older mice survived a dose of killing flu… 100%.

So why do so many people take vaccines if they are older, and they don’t work due to compromise immune systems?

#30

It’s hard to find good data on this topic to make an informed decision besides following blindly either one’s instinct (based on previous Covid vaccinations and infections and other anecdotal evidence) or government recommendations (that might be influenced by big pharma’s lobbying but also by a desire to minimize spending).

I found these three papers helpful:

So, assuming that myocarditis is the top risk with the vaccine, for people above 75, the risk/benefit ratio seems to benefit the vaccination. Same for 12-to-39-year-old females. For young adult males, though, it’s less clear. You avoid 14/100,000 severe Covid (maybe less for healthy males?), but you get a 1/100,000 risk of myocarditis.

Do we know if the updated 2024 vaccines are safer than the previous ones? I can’t find data on this.

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#31

Given that I’ve seen zero cases of severe covid in the last year, and none of my colleagues have - by the way I define it - it’s a challenge. The bad outcomes still occur for sure, but now, it is primarily an elderly person with lots of comorbidities who is barely capable of caring for themselves or with support is still hanging on in the community. Essentially anything can tip them over the edge - a fall, influenza, rsv, uti … and they get covid. They have some minimal hypoxia … that gets them severe covid in some individual’s assessments.

I’d take the stance that we absolutely must look at what the true incidence of unusual and unexpected outcomes are. e.g. the 19 year old I had with no comorbidities,early on with severe pneumonitis, hypoxia - ended up ventilated. A colleague also with no comorbidities, 29 years old … in hospital 8 months including months of ECMO. Now those were in the early days, and those I call severe covid and unexpected. Those cases and many more put fear into those of us getting exposed daily to meticulously avoid infection and get vaccinated on every occasion possible.

As we’ve moved to it being endemic, my observation is that the severe outcomes and unexpected outcomes are exceptionally rare. The other observation is that the vaccines may briefly be effective - not for not catching covid, but for hospitalization, but this quickly wanes, and new variants continue to come forward.

I absolutely recommend older individuals with comorbidities have all recommendations for immunization met. I suspect the stated benefits are very much overstated, especially in the current milieu of covid vs. vaccine.

@Agetron I think optimizing T cell function to the degree possible is a critical item in slowing aging and staying alive, whether it be avoidance of malignancy or death/disability due to viral infections which occur with aging. If I were to be getting an immunization, I think I’d grab it 3 days after Rapamycin once coming into recovery and maybe hold my next dose of Rapamycin. Don’t know if that is correct, but think being in recovery post mTORC1 inhibition, with a immune system that is well exercised would make sense to me logically. In older individuals, we have stronger strength flu vaccines for example, to supply several times the antigen provided to younger populations. The same with the shingles vaccine - with them anticipating that the immune system is weak and more antigen will be needed to wake it up.

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#32

Are you sure about this? The data I’ve read show a transient (maybe 3 month) rise in antibodies which does indeed cut infection risk, while the T-cell response lasts up to a year and cuts risk of hospitalization in half, and also tends to protect against emerging variants as well.

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#33

Sharing FYI, not because I agree or disagree with this statement:

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Source

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#34

As I read all the replies here it reinforces my opinion that, unfortunately, COVID has stopped being a health problem and has become a political issue. You’re either pro vaccine, pro mask, pro isolation, or you’re against all the above. Very few people seem capable of taking in the scientific data and making informed decisions.

The current Covid variants cause minor disease and our T cells are perfectly capable of fighting it off unless you are immunodeficient. The virus has not changed enough to elude our immune system. “Long” Covid has not been well defined as of yet and may or may not be significant.
I am not anti vaccine. Those original shots 4 years ago saved millions of lives. If you want to get vaccinated, go ahead. The downside is minimal. But it won’t stop infection or transmission. Side effects are real. Don’t be misled by myocarditis rates that are based on whole population numbers, not specific to age and sex groups in which the risk is higher and the benefits negligible. Two manufacturers have stopped vaccine production because of adverse reactions.
The WHO does not recommend vaccination for healthy people.
I’ve had 3 doses of the vaccine without complications, and I’ve had Covid 3 times without complications. If I go a couple years without getting Covid, I may get the vaccine.

And don’t listen to anything Eric Topol says about Covid. He has gone far left on the issue.

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#35

And there’s a severe lack of data in your reply, if you don’t believe the FDA’s number of 1 in 100,000 myocarditis, cite your own, that is also not based on a 3 week booster schedule as that increased the risk according to the FDA.

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#36

That is exactly why I get vaxxed. I’m not afraid of ending up in the hospital or dying, but I see too many otherwise healthy people (all over 55) having long lingering effects. Can some of these be coincidences, sure, but I don’t believe it’s all of them. I can handle feeling like death for only a week or two, even if it’s something I would prefer to avoid.

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#37

This summer, I’ve had multiple friends say it’s the sickest they have ever been. I believe you when you say you haven’t seen it. I wonder if there are regional sub-strains?

#38

Are you claiming that a booster won’t cut your risk of infection, even for a few months? On what basis are you making this claim?

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#39

This is the best I could find, about last year’s updated vaccine: Effectiveness of the 2023–2024 Formulation of the COVID-19 Messenger RNA Vaccine 2024

In multivariable analysis, the 2023–2024 formula vaccinated state was associated with a significantly lower risk of COVID-19 before the JN.1 lineage became dominant (hazard ratio = .58; 95% confidence interval [CI] = .49–.68; P < .001), and lower risk but one that did not reach statistical significance after (hazard ratio = .81; 95% CI = .65–1.01; P = .06). Estimated vaccine effectiveness was 42% (95% CI = 32–51) before the JN.1 lineage became dominant, and 19% (95% CI = −1–35) after. Risk of COVID-19 was lower among those previously infected with an XBB or more recent lineage and increased with the number of vaccine doses previously received.
The 2023–2024 formula COVID-19 vaccine given to working-aged adults afforded modest protection overall against COVID-19 before the JN.1 lineage became dominant, and less protection after.

So the protection offered by these updated booster seem “modest” at best, non significant at worst. And the more vaccinated you are the higher your risk of Covid?!

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#40

Assuming this is right, do unvaccinated people even get themselves tested for covid? They don’t even believe in its existence.

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