#41

I have looked into this quite a bit and there are certainly conditions where glycine might become quite rate limiting, maybe even more than NAC, such as in very old people. But this appears to be the exception rather than the rule. Cysteine is generally well recognized as being usually rate limiting for glutathione synthesis. In support of that, there is a wealth of evidence for NAC increasing glutathione levels when given in isolation while evidence that glycine does the same without NAC is scarce.

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#42

Yes, most glycine and cysteine deficiencies are in older people. Could you share the information that shows cysteine is rate limiting in younger people? I always want to expand my knowledge base.

#43

Any study that shows that cysteine or NAC given alone (without glycine) is proof that cysteine is rate-limiting for glutathione synthesis. Such studies are easy to find on PubMed. Here is one example that was done on young adults: Modulatory effect of N-acetylcysteine on pro-antioxidant status and haematological response in healthy men - PubMed

Here is more evidence from cell cultures in animals:

“In cultured neurons, the availability of cysteine limited the cellular level of glutathione.”

This is from this study: Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione - PubMed

#44

Hi,

I recently started taking Rapamycin for CFS too. Started 1, then 3,4, and 5 on 4th week and have taken that 2, maybe 3 times. Will let you know if it helps in the months to come. I’m having occasional slight nausea so if regular blood work shows no other reason may go down to 4. Good luck!

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#45

Hello Alex,
How are you doing since July 23 ?
I have ME/CFS, just joined this group and started Rapamycin:
Rapamycin dose regime for ME/CFS? - General - Rapamycin Longevity News
Best, Maxi

#46

Hi Maxi,
I got a Basel Cell Carcinoma removed from my face in January 2024. I gave up on rapamycin after about 6 weeks because Adam Bataineh said to me, on an exploratory phone call, that I shouldn’t be taking rapamycin if I have a history of skin cancer. So I was very disappointed, but stopped. However, I already recovered from M.E. for 19 years on a ketogenic diet. My husband died in 2020 and I lost the plot and went back to what most people eat. Within a year my ME returned after a bout with covid. On 11th September 2024, 5 months ago, I’d had enough of ‘enjoying’ what everyone else eats and went back to what worked before. I restarted the ketogenic diet, and within a week I started picking up. I’m really good now and went travelling around Albania in December and am about to go to Morocco. For me, the ketogenic diet worked the first time - and the second time. After a month of keto, I learned about the carnivore diet, a stricter form of keto (but easier to do) and I feel completely amazing on it. So I would love to go back on rapamycin, or use rapamycin cream, but I am too nervous of it given what Adam Bataineh said.

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#47

Did he explain why? I thought rapamycin showed a decrease in non melanoma skin cancers in transplant patients. What is the rationale behind not using it. @desertshores fights his precancerous AK quite well on his rapamycin regimen and his skin toner with rapamycin.

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#48

I thought the same as you but he said the research isn’t there and until it is he wouldn’t recommend it. I was very disappointed.

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