#109

My rational mind tells me it’s unlikely rapa was involved directly in the detachment, since I’d think we’d have seen a signal for this by now, especially given the much higher doses given to medical patients over the years, but the scary part for me is/was that we know rapa can interfere with wound healing and the detachment happened the day after I took a 4mg dose, so it was definitely in my system during the emergency eye surgery and early healing process. The eye has recovered well, all things considered, but I still have a 10% chance of detachment in the other eye at some point in the future. The psychological trauma of the first detachment, and even the tiniest possibility that rapa was involved, has kept me away from it for the time being. The threat of losing vision, even in “only” one eye, is pretty scary.

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#110

I have floaters driving me crazy too. Just thought I was getting old or something. Maybe it’s the Rapa.

Never would have put them together, thanks.

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#111

It’s going to take a lot longer than 4 weeks (think in terms of several months at least), and a retinoid is only going to do so much for actual “wrinkles”. Retinoids are more likely to have a subtle effect on small “fine lines” over time and to help prevent or slow down further aging of the skin. Deeper wrinkles on the forehead, crows feet, etc are better treated IMO with skin-tightening procedures such as Fraxel laser, microneedling, and of course Botox/Dysport. I had an RF microneedling treatment to my face and neck last week and plan to keep doing this periodically for a while (since it’s free for me) and will be eager to see if it lives up to the hype. Since the backs of my hands are starting to get a bit “crepey”, I’m also going to have one hand treated so I can directly compare the two hands over time (a better experiment than doing half my face :laughing:)

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#112

I take a teaspoon of collagen in my first cup of tea as well as taking hyaluronic acid. It seems sensible to have some good inputs for connective tissue and my results are good. However, i cannot determine a cause and effect as yet.

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#113

Probably not reasonable to expect that an ointment is going to have a meaningful impact on my forehead wrinkles or my turkey feet (crow’s feet to small for valid analogy). More drastic measures are called for, at 70.

I was very satisfied with the improvements to ‘photoaging’ I got with the first product I used, just another ‘me to’ product, one out of dozens on Amazon. (Forgot to mention that it also included retinol.) I have some alternating dark and light strips on my cheeks, really mostly visible if I stretch the skin, that the first product partially reduced. Four weeks of adapalene completely eliminated them on one side, the other side is reduced as well, but not going completely without a fight, it seems. If they too disappear, then mission accomplished as far as I’m concerned.

Vanity, thy name is Leonard.

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#114

Len, there are some related threads that may be of interest:

Here: How to Reverse Skin Aging

and Here: Rapamycin May Slow Skin Aging (Drexel U. Study)

here: DIY Rapamycin skin cream

and here: DIY Rapamycin Toothpaste and Flossing Paste

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#115

You may find the resources below useful in the debate around Tretinoin or Differin. The sun is unavoidable in Australia so Differin 0.1 (Adapalene) is a solid option as it is significantly less effected by ultra-violet.

Efficacy and safety of adapalene gel 0.1% and 0.3% and tretinoin gel 0.05% for acne vulgaris: results of a single-center, randomized, double-blinded, placebo-controlled clinical trial on Mexican patients (skin type III-IV) - PubMed - Differin 0.3 is similar to Tretinoin 0.05 in terms of efficacy.

A comparison of adapalene gel 0.1% vs. tretinoin gel 0.025% in the treatment of acne vulgaris in China - PubMed - Differin 0.1 and Tretinoin 0.025 offer comparable efficacy, but Differin is less irritating

Comparison of adapalene 0.1% solution and tretinoin 0.025% gel in the topical treatment of acne vulgaris - PubMed - When comparing patients who had 75% or greater improvement in open comedones, Adapalene was shown to be significantly more effective than tretinoin

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#116

FYI

This week I would like to share with you some fascinating research on collagen. We often think of collagen as a natural product to keep our skin, nails and hair strong and younger looking.

However On March 04, 2021, the MD Anderson News Release published a fascinating study on how collagen may play a protective role in slowing tumor growth and metastasis.

This recent study from researchers at the University of Texas MD Anderson Cancer Center supports the novel therapeutic approach that we may have greater success in treating cancer by adding collagen to the program.

To come to this conclusion, the research team created a mouse model in which collagen was genetically removed from these cells, called myofibroblasts. More than 50% of the total collagen was absent in the tumor microenvironment.

With collagen reduced, pancreatic cancer growth accelerated and the overall survival of the mice significantly decreased, suggesting that collagen plays a vital role in blocking cancer progression. The study also suggests collagen can prevent cancer metastasis by keeping dormant tumor cells asleep.

Collagen as many know also supports tissues, bones, skin, hair, and eyes. Helps reduce and prevent premature wrinkles. Improves and helps digestion, reduce joint pain and increase bone density. And to top it off collagen is good for your heart.

To find out more about the collagen CLICK HERE

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#117

When I read that collagen can reduce the growth of Cancerous cells grows, I think of the extracellular matrix. One speculation is that a healthy ECM might make it harder för cancer cells to grow. And Collagen is the most abundant fibrous protein within the interstitial ECM and constitutes up to 30% of the total protein mass of a multicellular animal.

The extracellular matrix is a large network of proteins and other molecules that surround, support, and give structure to cells and tissues in the body. The extracellular matrix is also involved in repairing damaged tissue. Abnormal changes in the extracellular matrix may lead to the development of certain diseases, such as cancer.

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#118

Here is a chart that shows the amino acid content of collagen. So, 33.7% of collagen is glycine. A recommended daily dose of collagen is 20-40 g. I take 11 g of collagen peptides daily in my coffee. Tastes like creamer so it’s a healthy exchange.

https://www.researchgate.net/figure/Percentages-of-amino-acids-in-human-collagen-I-Amino-acid-composition-of-a-collagen_fig1_351426852

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#119

So, collagen is not one thing–there are varying types and souces. It can be derived from animals, fish skin, and even eggshells, and the resulting amino acid mix will likely vary accordingly. If you want to know what’s going into you, I’d get more specific on your particular source (which likely still will vary, since it’s coming from a variable source) before concluding the proportions.

That is, what are you consuming?

The link you give explores what’s in the human body (“Percentages of amino acids in human collagen”), which is not necessarily the same as what you’re consuming. (Unless you have a source for collagen that is, ahem, canibalistic, in which case, maybe? :smiley: )

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#120

You can use it as a rough estimate.

#121

You can use it as a rough estimate.

Maybe? I don’t claim any expertise. I found this, though:

"Results demonstrate that FS [fish skin] collagen as well as BAT collagen contains no cysteine and significantly different amount of hydroxyproline. In BAT [bovine Achilles tendon] collagen hydroxyproline content is 30% higher than hydroxyproline content of FS collagen. In bone collagen the amount of hydroxyproline is two times more than in FS collagen. "

Amino acid composition in determination of collagen origin and assessment of physical factors effects

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#122

全文：

Amino Acid Composition in Determination of Collagen Origin and Assessment of Physical Factors Effects

https://sci-hub.se/10.1016/j.ijbiomac.2017.07.013

Great paper, I have no expertise either but this seems like a big deal to me so I’m working on it. Thanks,

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#123

The limiting amino acids needed to make collagen are glycine and proline (hydroxyproline) since you need so much of them. So if you don’t have enough of these, you can’t make collagen.

Supplementing glycine and proline also works to boost collagen production because you can get the other amino acids from non-collagen protein sources. I’ve tried this approach and it works. Now I supplement both hydrolyzed collagen as well as glycine and proline. (Glycine and proline have other benefits too.)

Hydrolyzed collagen supplements typically list their amino acid content on the container.

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#124

A new study:

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#125

Yes, I’m taking >60g per day which is ~50% of my total protein intake. Low methionine, high glycine… win win.

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#126

" I’m taking >60g per day"
That’s a lot of collagen. I take about 20gm/day in my coffee. How do you take >60 gms?

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#127

Same, I have 20g in a hot drink before each meal… and then often 10g before bed.

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#128

Daily, I take a mix of 7.5 gr collagen, 2.5 gr MSM, 250 mg chondoitin sulfate. Some days I take the double amount.

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