#61

Well…let’s look at their sources, which are not very illuminating (and yes, I followed the links):

Sources:

I’d like a touch more. :smiley:

#62

If that is the case thank you for letting me know because I didn’t know that. I do take almost all supplements at same time, around 7 Am.
Take most days, 3-4 days per week:
Glycine, lysine, vitC, D3, K2, magnesium, iron, zinc, copper, potassium, vit B complex, taurine, NMN, COQ10, Serine, theanine NAC, Fenugreek, black MACA, ashwaganda, , valerian root, DIM, Calcium AKG, choline and couple more I might have forgotten

PM just started lately, theanine, trophtophan, valerian root, glycine and taurine (now I’ll alternate taurine and glycine). Does anyone see any conflicting ones on the list?

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#63

Has anyone tried Pregabalin (Lyrica) for sleep? I see it prescribed quite often for sleep lately.

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#64

Regarding
Suvrexant…

There are sellers on India mart for this medication, and it looks far cheaper.

#65

LaraPo, Tell me more about your valerian root supplement. I’ve tried it before without any effect, but maybe the brand I used was not potent. What brand do you use and at what dosage? And, do you use it every night? Thanks.

#66

It’s liquid valerian root extract by NOW. I use it some 2-3 hours before sleep. Then I take magnesium, tryptophan 1 hour before sleep, melatonin and glycine when I’m already in bed. I fall asleep quickly, have my deep sleep stage shortly after that, sleep 7-8 hours on average.

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#67

I think valerian root extract is underrated. It is very useful in getting back to sleep if you wake up in the middle of the night.

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#68

It’s a controlled substance in the US. Remember to check your country’s laws before ordering a drug from India.

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#69

I don’t think they will even ship it to USA. I tried to buy something that I was not aware it was controlled substance and all the Indian guys I asked said no we can’t ship it.

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#70

I take Quviviq (daridorexant) with good results. Even though it’s brand-only and not covered by my insurance, I’m still able to get it for $25/month (with prescription, of course) from a mail order pharmacy in the USA called KnippRx. I still have issues waking up earlier in the morning than I’d like (especially with the recent daylight savings time change), but it’s made a big difference in my overall quality of sleep with no morning grogginess or other side effects.

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#71

What dose do you take if you don’t mind me asking?

#74

And sure enough it is. Good to know.

Suvorexant and Alzheimer’s
#75

That’s the first I’ve heard of that. Will you please provide a source for that info?

#76

One enhances mTOR (glycine) and another one inhibits it (taurin). What is it if it’s not a cancelation?

https://journals.physiology.org/doi/full/10.1152/ajpregu.00043.2016#:~:text=Reproduction%20and%20Development-,Glycine%20enhances%20muscle%20protein%20mass%20associated%20with%20maintaining%20Akt-mTOR,in%20piglets%20challenged%20with%20LPS

https://www.researchgate.net/figure/Taurine-treatment-decreases-mTOR-activity-and-inhibits-phosphorylation-of-ULK1-and_fig2_350026113

Do you think it makes sense to take them together?

1 Like
#77

Great question! I wish I knew the answer. My thoughts are… There are many things that either “enhance” or “inhibit” mTOR. Glycine is an amino acid. Leucine, arginine, and methionine are also amino acids that signal or enhance mTOR. Protein (complex of amino acids) intake in general enhances mTOR. Some believe high protein intake promotes aging while others insist high protein intake is beneficial to stay muscular and fit while aging. We can probably all agree that we need some protein in our diet. And we can only be so concerned about, getting what we believe to be the optimal amount of protein, enhancing mTOR. Resistance training activates mTOR. I think we can all agree that resistance training is more beneficial to health and longevity than not.

I don’t know the answer. I hope someone does and will chime in. Currently, I take glycine (in gly/nac). I also take taurine. While glycine may be enhancing mTOR (I’m guessing it is a weak enhancer), some of the benefits of glynac are increased glutathione, increased mitochondrial function, and potentially increased healthspan and lifespan. I don’t think glynac does this because of its effect on mTOR. Please correct me if I’m wrong. Taurine has many benefits. But is it cancelled out because I do things that enhance mTOR like resistance training, eat high protein, or…. take glycine.m??? I guess I don’t know. I do take Taurine on an empty stomach so it has less competition for absorption. But, I’ve been taking it with glynac so maybe I should look at that. I’m already struggling with what supplements to take on an empty stomach or with food or in the AM or PM or what vitamins to take separately because they compete. Same with minerals many compete for absorption so I take them at different times.

I don’t think activating mTOR is always bad. Most of us are on an intermittent or pulsed dosing schedule of rapamycin. It’s so powerful that mTOR will be inhibited for a period of time when we dose regardless of what we are doing or supplementing.

Having said all of that, I’ll add glycine and taurine to the list of things I obsess about. :joy:

#78

I have been trying different doses and time for tryptophan for better sleeping. If I take approx 100mg immediately before going to bed, my deep sleep stage doubles and happens at the beginning of my sleep.

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#79

@Walter_Brown, many studies have been done on cognitive behavioral therapy as a treatment for many disorders, including insomnia. It’s effectiveness as a sleep aid is almost indisputable.

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#80

@Alex, unfortunately you won’t find anything that knocks you out like mirtazapine except for maybe quetiapine, which is also an anticholinergic. I’d try CBT, which is said to be effective even for chronic insomnia.

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#81

And maybe a thousand times more costly. :sweat_smile:

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#82

For Alex, yes, but not for us geezers.

Actually, most people need no more than seven or eight sessions. May be worth a grand or two.