When I developed bad hives, I stopped Rapa until they went away. My wife develops facial acne when she takes too high of a dose (3 mg + GFJ). Wait for the side effect to resolve and then try again at a lower dose. I’ve found that taking 4 mg + GFJ will create little itchy spots that don’t turn into hives and go away after a few days. 5 mg + GFJ will cause several hives to break out over my body. 6 mg + GFJ makes me look like I was mauled by a horde of mosquitoes.
I’m alternating between 4 mg and 5 mg with GFJ with some breaks interspersed. 6 mg + GFJ was just too irritating.
4 Likes
59vw
#1191
Sounds like Ringworm which is indeed a fungal infection. Pretty common though. Not something I’ve heard in others taking Rapamycin, may just be true true and unrelated. Not a big deal to treat topically with clotrimazole. A close up picture of one of the circles would help.
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adriank
#1192
My tinea (fungal infection/ring worm) all went when I increase my dosage to 20mg per week. Previously when I was just starting, the tinea was still on my arm and nails. My nails are now nice and clean. Now I am on 10mg every 2 weeks. I think you need to increase your dosage to kick them off. At 10mg I do not get any side effects anymore. I am guessing my body is getting used to it. Basically I am just targeting 3ng/mL or more after 85 hours of taking rapamycin. I also go to the public sauna and spa everyday which are notorious for fungal infections. I do not walk around barefooted.
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jnorm
#1193
I feel like my appetite is suppressed for a day or two after dosing.
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adriank
#1194
Yes, it is like fasting. I don’t get the hunger pangs when I take rapamycin. Great if you like fasting.
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I take 3 mg rapamycin with grapefruit and some oil every 11th day. I suspect my enamel loss has nothing to do with rapamycin, but post this since some on this forum also take LDN:
Since my last dental checkup half a year ago, I have lost enamel resulting in more than 10 teeth needing fillings. I also broke a tooth vertically while chewing (and I have not yet been able to find any dentist in Europe that is willing to try to save the tooth using e.g intentional replantation, any dentist suggestion is welcome). I have bruxism and wear night guards. I took LDN 3 mg/day, but after reading on Reddit that some were suspecting LDN to cause loss of enamel, I stopped taking LDN.
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adriank
#1196
enamel loss??? I have never heard of that… and I would be pretty worried should it happened to me.
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Yes, I am worried and try to find the cause. I have experienced waking up with very dry mouth at night the last week and I see some here have reported dry mouth as a side effect of rapamycin. But this is after the dentist told me >10 teeth need filling. I cannot remember having dry mouth earlier being on the same dose of rapamycin. I have decided to continue with rapamycin.
A reason for the enamel loss could be acid (combined with my bruxism and possibly too hard toothbrush and brushing too early after eating the acidic food). I picked and ate a lot of raspberries this summer and filled up the freezer eating raspberries daily.
AnUser
#1198
I would recommend starting to use stannous flouride toothpaste (Oral B Pro Expert / Crest Pro) with an electric toothbrush.
See this:
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adriank
#1199
Get some xylitol gums and have them after you have something to eat… it is supposed to prevent decay by stopping the bacteria.
3 Likes
Took my first dose of Rapacan yesterday morning, 1mg at around 8am, and developed a rash on my neck around 10pm. Burning sensation last night, and today’s it’s itchy.
Getting a haircut is the only other possible cause I can think of, but I’ve never developed a rash like this from going to the hairdresser before, so I’m fairly sure it’s the rapamycin.
Small price to pay for the benefits I’ve experienced with my asthma so far.
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Yes - its probably the rapamycin (in combination with the haircut). Its surprising at a this low a dose. I would wash the pillow case before your next dose in case its got hair on it that causes irritation.
5 Likes
Good point, it may be the combination of haircut + rapa. Barber needs to clean his clippers when he has a immuno-suppressed rapa client under his knife 
Given the location of the rash, I agree with @RapAdmin and I’d wash your pillowcases and sheets as there may be something such as dust mites along with the Rapamycin that triggers the rash.
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sol
#1204
For some, 1mg is a small dose. For others, it’s quite noticeable in terms of effects. I don’t want to minimize reactions at low doses.
Also, there’s the spin-the-effects-wheel of inconsistent results. One might not have the same result next time.
6 Likes
adriank
#1205
I am now taking 2mg with GFJ. Just had my bloodwork 2 hours ago… so will know the results in 2 days. I am expecting it to be above 3ng/mL after 50 hours.
I got the result today of 4.7ng/mL after 50 hours.
Should I drop my dose to 1mg?
@DrFraser drop to 1mg? Or is last week’s residual causing this week to bump up? I was expecting it to be about 3.7ng/mL
1 Like
adriank
#1206
That is too low a dose to even affect you.
That is a bit of a conundrum. 1 mg will be too little, and 2 mg too much. I’m surprised by that level being so high. So there are 0.5 mg tabs - I’d think 1.5 mg with GFJ and recheck. I’m still surprised by this level with just 2 mg.
2 Likes
adriank
#1208
I think I will stick to 2mg… so weird… or maybe reduce my GFJ or cut out the hemp oil … or maybe try it without my meal and see the results… next week I will do it without eating. That should drop the level … by how much I will be curious to find out.
1 Like
You can just bump your interval out to 9 days as another option.
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