Good luck. Rapa is very confusing to me. It can cause immunological issues but it also can boost the immune system. I get the occasional infection (mouth, elbow, neck) but I never get sick (cold, sinus infection, bronchitis, flu) anymore. It feels like the upward progression of physical fitness: regular workouts make me stronger over time but in the short run after each workout I am tired and weak. If the lion comes for me after a workout, all my efforts will not save me.
6 Likes
Agetron
#988
I agree on it making you leanā¦ shredded. Can eat all I wantā¦ no weight gain in 3 plus years as to libidoā¦ try going on tadalafilā¦ just wise for urinary health. My urologist encourages itā¦ after 2 yearsā¦ no regrets.
3 Likes
What dosage of cialis do you use? 2.5 or 5mg? Take in AM or PM? With food (fat) or without?
1 Like
Agetron
#990
I use 5 mg at night tadalafil which is generic cialis. Wake up knowing it worksā¦ lol.
You can take it anytime - recommended 3 hours before being active. 
Daily useā¦ always ready.
Doesnāt reqire a mealā¦ just down it with water.
5 Likes
@stealle Berkley says the codes are working again.
Alex
#992
I think it is the hormones in meat products or perhaps just more animal protein.
For instance, I am acquainted with many Asian families and their American born children are often giants compared to their parents.
5 Likes
SNK
#993
Frozen berries and a spoon full of Raw Honey (mixed in) should do the trick.
2 Likes
stealle
#994
Thanks! I didnāt think that was going to happen. I ended up ordering a similar product from humann.com since itās cheaper but Iāll probably go ahead and order some Berkeley anyway to try and compare. Thanks!
1 Like
I did the same thing originally but found I had to double the dosage on humann to get the test strips to show good results.
59vw
#996
Re: MTORC1 activity cyclingā¦Iām not sure whats going on with respect to feeling better on a 2 or 3 week schedule but Iām not convinced that translates into a dose that is more effective or better for you.The papers that look at S6 kinase phosphorylation suggest that MTORC1 has pretty much full activity (or more if you buy the rebound hypothesis) after 7 days. So weekly dosing should fully cycle for most. Sirolimus levels are usually undetectable or < 1 ng/ml at 7 days for standard dosing (0.1 mg/kg) also arguing that MTORC1 repression is minimal. T1/2 calculations also support a low level with minimal MTORC1 inhibition since the 60 hour average T1/2 really only applies to the sirolimus level at 24-48 hours (1-2 ng/ml), not Cmax.
2 Likes
Which papers are you referring to here? I donāt recall seeing papers that show how quickly S6 kinase/mTOR1 recovers after disappearance of rapamycin from the blood or cell culture.
I agree, the peak is going to be where most people experience significant mTORC1 inhibition. Iām not sure if levels after 24 hours are high enough for significant mTORC1 inhibition to continue for a day or few after the peak. Of course it depends somewhat on the dose, but even those taking pretty high doses will most likely have only moderately high levels in the blood after the initial drop from the peak. So maybe they will get some continuing inhibition but not a lot, I would think. Btw many people here will have levels higher than 1-2 ng/ml after 24 hours, some even above 5 ng/ml if they take a high dose.
1 Like
My continuing confusion is over whether creating an effective rapa peak more often is somehow better. For example is a good peak 52 times each year ābetterā than 26 peaks of rapa? Relatedly, does taking time off lower the benefits in some way (problems come back / benefits fall away or lose time to make a difference)?
2 Likes
As an update. I am sticking with the switch to a 2 week rapa cycle even though I have discovered that some of my ārapa side effectsā were actually metformin side effects. I stumbled on this fact when I used metformin even though I was skipping my rapa dose. The fatigue and poor recovery I had attributed to rapa came back after using metformin for 5 days (500mg/day). After quitting metformin the symptoms ceased. Iāll be cutting back on metformin too (3 days ever 2 weeks, around rapa dose). Berberine does not create these effects, so Iāll use berberine most of the time.
5 Likes
SNK
#1000
Clearly any bodyās guess with regards to dosage and frequency. I have now decided to go on once a month schedule, the main reason being because weekly was screwing up my sleep completely and literally getting only 5-6 hours daily (very dangerous for health and longevity). took my dose three weeks ago and for last week or so I have returned to my regular 8 hours sleep nights.
BTW, the best I ever felt after trying say 50-100 things was when I managed to stay 4 days without food. I donāt know if it is good for longevity, but I literally felt as if I were 20 years old again. Hard to do but boy do I ever crave that feeling! Everything else has had either marginal benefit or nothing at all including RAPA. Perhaps in my case it is harder to notice any benefits since Iām 100% healthy and never taken any medication other than what I take now for longevity (most came from these boards)
6 Likes
My problem is I have a large number of interventions and so I am not always what causes what, but I am with you on infrequent dosing. I look forward to my 21 day dosing on Rapa, but want to reduce the frequency ideally.
2 Likes
I would agree that fasting had a profound effect on me that surpassed rapamycin, though somewhat in parallel. Sleep was impacted by both. I had an annual physical after a 5 day fast and my blood lipids were raised. I found out this was typical in fasting. Also, like rapamycin, I found my energy levels increase while fasting. And doing strength training while fasting preserved muscle mass. At 69, I no longer fast as its merits are diminished in light of muscle preservation. There is certainly evidence fasting has long-term downstream impact.
I wouldnāt be disheartened by ā50-100 thingsā you have tried, as it may well impact where you land health wise as you enter your sixties. Looking back at my own broad similar stack, I think some have preserved testosterone levels, muscle mass, and anticancer. (I am still a proponent of long-term use of aspirin for example, despite recent reports against its use). Anyways - a broad use of supplements isnāt a bad strategy as who knows which may work? And surprise, after 2 years on rapamycin, I find it actually helps my sleep.
5 Likes
SNK
#1003
Same here. I baby aspirin I think is beneficial. I do take most days unless i forget to take it.
4 Likes
59vw
#1004
Iām also uncertain what to make of āpeaksā. Itās not clear to me that the peak rapa decline is due to excretion. It may be that it is due to rapa exiting from blood into other tissues. Since we only test blood it appears to have gone away. I think storage in other tissues is more likely than excretion since it doesnāt make sense that the excretion rate would change after 12-24 hours. Furthermore, the T1/2 may be different in other tissues causing build up in some organs. All something to think about.
2 Likes
59vw
#1005
The paper showing S6 activity is Figure 2 of this paper by Ezra Cohen. But I think Iāll retract my statement as I really donāt trust this paper as Iāve indicated before. 
1 Like
I have to amend this to give the rapa some love.
After being back on rapa for some time, I unequivocally have more stamina and am moving better and my libido is creeping back up to the norm. I may have less off the wall energy, but I could walk miles easier
6 Likes
