#146

90% DMSO is a very uncomfortable topical formula. It will itch and burn for 20 minutes. I think it could cause problems with your skin over time. Not sure it will bring the Rapa through either. What reference do you have that this might work?

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#147

Let us know how it goes. I personally prefer transcutol as the solvent / reagent to dissolve the rapamycin and dasatinib in. It’s not as harsh as the DMSO.

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#148

I apologize for the miscommunication. To clarify, I will be using 90% DMSO but diluting it with distilled water to 70%, which is the concentration at which there is systemic absorption. I will be using rapa powder, not pills. My goal is to replace the rapa pills with the transdermal delivery, which would have the additional benefit of rejuvenating my skin. One of the main reasons for this DIY method is that whatever anti-aging protocol I use on my face is also used on my body, and therefore must be cost effective. This is experimentation and I wish I could find a dermatologist willing to biopsy my skin to assess results.

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#149

Rapa is not a small molecule and it’s very questionable whether it will go through your skin no matter what the concentration. Also you’re not saving much money. From India I spend $3/ two weeks. Take with Grapefruit Juice and you’ll get plenty. Maybe swig it down with EVOO.

I’m not trying to discourage. I don’t think it’s unsafe. It may work on your skin. I don’t think it’ll get through. Also it will itch and burn and smell bad even at that low rate. If you decide to do it and want to know if it worked, do a blood test a few hours after, this will give you an idea of the rate of absorption. Good Luck,

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#150

It has been 17 days, what sort of results have you had so far? Do you plan on getting a blood test for sirolimus to see if you are absorbing it?

What was your skincare routine like before if you don’t mind me asking?

#151

Interesting. Did someone try their new OS-01 HAIR peptide scalp serum? Its featured here:

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#152

If rapa cannot penetrate the skin, then how would you explain why it is effective for the treatment of facial angiofibromas? I am not using it transdermally to save money, in fact, I need to order more of the tabs from India. I agree that I must get a rapa test to ensure that the level is systemic. Even if the effect is not systemic, I would still use it topicallly, although I still have no way of knowing objectively if my experiment actually rejuvenates my skin. I had a Visia test recently, but that’s very limited in terms of an assessment. Have you placed any orders recently? I am concerned about orders getting seized with the recent changes.

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#153

I agree, because using DMSO in this way is a huge PIA. I have to wait 15 min for it to absorb before washing it off. Thankfully, this is only once a week. Skin laxity and UV damage begins at the dermis, so whatever we use to mitigate this must be active at that level. Interestingly, angiofibroma are formed in the dermis layer, but the topical rapa formulations being used to treat it do not work at that level.