Here’s the formula for dose conversion:
Human Equivalent Dose (HED)=Animal Dose×(Animal KmHuman Km)\text{Human Equivalent Dose (HED)} = \text{Animal Dose} \times \left(\frac{\text{Animal Km}}{\text{Human Km}}\right)Human Equivalent Dose (HED)=Animal Dose×(Human KmAnimal Km)
For mice, the Km factor is 3, and for humans, it is 37. Therefore, the conversion factor is:
(337)\left(\frac{3}{37}\right)(373)
Dasatinib
For dasatinib, the mouse dose is 5 mg/kg body mass.
HED of dasatinib=5 mg/kg×(337)\text{HED of dasatinib} = 5 , \text{mg/kg} \times \left(\frac{3}{37}\right)HED of dasatinib=5mg/kg×(373) HED of dasatinib=5×0.081\text{HED of dasatinib} = 5 \times 0.081HED of dasatinib=5×0.081 HED of dasatinib≈0.405 mg/kg\text{HED of dasatinib} \approx 0.405 , \text{mg/kg}HED of dasatinib≈0.405mg/kg
Quercetin
For quercetin, the mouse dose is 50 mg/kg body mass.
HED of quercetin=50 mg/kg×(337)\text{HED of quercetin} = 50 , \text{mg/kg} \times \left(\frac{3}{37}\right)HED of quercetin=50mg/kg×(373) HED of quercetin=50×0.081\text{HED of quercetin} = 50 \times 0.081HED of quercetin=50×0.081 HED of quercetin≈4.05 mg/kg\text{HED of quercetin} \approx 4.05 , \text{mg/kg}HED of quercetin≈4.05mg/kg
Therefore, the equivalent doses for humans would be:
- Dasatinib: approximately 0.405 mg/kg body mass
- Quercetin: approximately 4.05 mg/kg body mass
Therefore, for a male weighing 175 pounds (approximately 79.38 kg) with a BMI of 22, the calculated dosages are:
Dasatinib: approximately 32.15 mg
Quercetin: approximately 321.78 mg
I can’t claim the veracity of this as it comes from Claude, but think it is correct.
Just tell Claude your weight and BMI.
This was my initial query:
“Male C57BL/6 mice were used in a study and given senolytic drugs dasatinib (5 mg/kg body mass) and quercetin (50 mg/kg body mass). What would be the equivalent dose for humans?”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924942/#:~:text=In%20this%20study%2C%20we%20show,metabolic%20function%20in%20old%20age.
