It may be, but I’m always very skeptical of research supporting a compound that is really almost exclusively done by a single lab or group of people. It seems like that may be the case with this compound. How many third party validation tests have every been done by different labs on the same compound with good results?

This compound seems to have been around for a long time. If there isn’t much in the way of 3rd party validation, then I’m not too swayed by the single source of research; it reminds me too much of the resveratrol research by David Sinclair that has never been replicated by any good third party labs.

Call me skeptical.

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MitoLab is a laboratory situated in the UK, and that’s where I intend to buy SkQ1 from.

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Hence, it needs to be validated/debunked by the ITP or another independent and reliable third party.

Perhaps. I’m not sure there is even enough research to make it of interest to the ITP. It would be interesting to know if the ITP has ever had it submitted for evaluation.

There seem to be a total of about 35 papers that have been published that mention SkQ in the past 15 years or so - see here:

I don’t see a single lifespan test in any type of organism yet - no nematode or fly / drosophila lifespan tests even. I’m not sure if the amount and type of data that is available so far justifies an ITP type of test.

Rapamycin was tested by the ITP after many years of successful yeast, nematode, and fly longevity studies.

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However, weren’t there longevity studies conducted on dwarf hamsters, mole-voles, and mice?

I’m not understanding your question - you mean for SkQ or rapamycin?

SKQ1.

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Contact Vladimir P. Skulachev directly

Director, Academician of RAS, Grand PhD (Biology)

Telephone: 8 (495) 939-55-30
Address: корп. А, комн. 418
Fax: 8 (495) 939-03-38
E-mail: skulach@belozersky.msu.ru

Thank you, will investigate too.

The manufacturer of SkQ web site

True - I view RT (Russia Today) as simply a propaganda outlet for a dictatorship in Russia. Given the abundance of other very valid, less political outlets, for scientific information I would prefer we not do anything to validate this outlet and regime.

RT has regularly been described as a major propaganda outlet for the Russian government and its foreign policy.[2] Academics, fact-checkers, and news reporters (including some current and former RT reporters) have identified RT as a purveyor of disinformation[58] and conspiracy theories.[65] UK media regulator Ofcom has repeatedly found RT to have breached its rules on impartiality, including multiple instances in which RT broadcast “materially misleading” content.[72]

In 2012, RT’s editor-in-chief Margarita Simonyan compared the channel to the Russian Ministry of Defence.[73] Referring to the Russo-Georgian War, she stated that it was “waging an information war, and with the entire Western world”.[17][74] In September 2017, RT America was ordered to register as a foreign agent with the United States Department of Justice under the Foreign Agents Registration Act.[75]

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He has passed away.

It’s a fact that Russia has a history of publishing fake papers, almost half of them according to some.

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I can tell you with 95% certainly what Dr. Miller will tell you about this compound.

“Submit a proposal.”

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The documentary hails not from RT, it’s produced by Первый канал. I learned Russian during my military days in a Western country, so I can understand it. You’re the boss of your site, you decide its content. As for the Ukraine situation, I’ve got no horse in that race, and I only found out about SkQ1 today.

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And again, the paper in question wasn’t published in Russia. It’s in an AMERICAN, PEER REVIEWED JOURNAL! Fact.

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Well, that settles it.

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Even American papers have a 10% fake rate. So those papers go through a Western review system and still get published. Even for American studies, I require 2 or 3 successes before it is actionable. Unless it is from a trusted source like the ITP.

It’s just hard to go on blind faith on one study from a country known for a 50% fake ratio. I’ll get enthusiastic when there are multiple studies. I think Rapamycin has had over 64.

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I’m not a researcher, and I don’t claim that I closely follow the rankings of the different peer reviewed academic journals, see ranking here https://www.scimagojr.com/journalrank.php

but…

I do come across articles about the growth in the US and elsewhere of the “pay to play” academic research journals (where the academics have to pay the journal thousands of dollars per paper to have it published) and the related issue with some of the less rigorous of them that detractors call “paper mills”, predatory publishers and junk journals.

So, US-based, or Russia based, or China-based, or otherwise, you have to be somewhat skeptical at all times. Peer reviewed doesn’t automatically mean quality, no matter what country its published in. I don’t put much time into looking into this issue but I have seen the news coverage of the issue increasing in the past decade, identifying it as a growing problem.

If I was a scammy businessman it seems it would be pretty easy to have a PHD candidate at some backwater university write up a few nice (fake) studies of my new miracle drug or nutritional supplement, pay $5,000 to have them published in these academic journals, and then use that published research as promotional literature to drive sales of my new product.

And since its relevant to this current discussion, I have to say I’ve seen that Blagosklonny’s journals (Aging, Ongotarget) are sometimes cited as problematic. I don’t have an opinion one way or another, but wanted people to be aware of the controversy:

Smut namely discovered that the journal Aging (impact factor 4.8) has published several utterly fake products from paper mills. Which is funny, because Aging has a very fancy editorial board, a who-is-who of American and European science elites. You know, the kind of which you, dear failed scientist reader, were supposed to emulate.

The US-based journal Aging is run by Mikhail Blagosklonny, a Soviet-born US researcher with a hefty PubPeer record, whom my readers will recall as chief editor of another outlet: Oncotarget, which also seems to be the go-to journal for every fraudulent cancer researcher. Blagosklonny’s main scholarly interest is however in achieving eternal life, and how to get there using rapamycin and its molecular target, mTOR. While Oncotarget is there for phony cancer research, Aging covers the other field of biomedical bullshittery, the anti-aging. In theory, at least. In reality, Aging accepts any trash in biomedicine, the fake papermill products Smut Clyde exposed are about cancer and nanotechnology.

In 2013, Science correspondent John Bohannon submitted 304 fake scientific articles to various open access journals, many of which were published by publishers on Beall’s List. Among these publishers that completed the review process, 82% accepted the paper. Bohannon stated “the results show that Beall is good at spotting publishers with poor quality control”. Beall stated that the results support his claim to be identifying “predatory” publishers.[16]However, the remaining 18% of publishers identified by Beall as predatory rejected the fake paper, leading science communicator Phil Davis to state “That means that Beall is falsely accusing nearly one in five”.[17]

Notable publishing groups to pass this sting operation include PLoS One, Hindawi, and Frontiers Media.[16][18] Frontiers Media would later be added to Beall’s list in 2015, sparking a controversy that is credited as a major reason for Beall eventually retracting his list.[3][19]

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Ha! Yes - fair point, Wikipedia is not a perfect reference, but it is easy to access and the links generally are reasonably good in terms of detail, and as a starting point if you want to research a given issue or topic.

I guess my issue is I just don’t like dictators (or royalty) and their “news” outlets, so you can call me biased :wink:

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As indicated by Dr. Ionodes and the “replication crisis,” there’s a lot of fake research on these very shores. Researchers suppress and cherry pick their data to produce a low p value.

SKQ1 will no doubt have an analog with some of the same properties. And there will always be another formula tweaked by the Chatbox. I don’t know if I want to keep taking supplements forever. It seems like I take too many now.

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