#442

You seem to be a nice person! :joy: Anyway, Brad Stanfield produces amazing content, and I’m glad he debunked Sinclair’s BS. I just said keeping known mistakes online was unprofessional, and I hope he’ll fix this.

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#443

I enjoy Brad Stanfield. He employs a fair share of marketing gimmicks to draw attention to his channel, and while the clickbait titles can be a bit much and occasionally misleading, the core information he provides is interesting and he seems ready to correct mistakes. The criticisms about bias do hold water, especially since his focus is heavily on supplements and—lo and behold—he’s launched his own multivitamin. All in all, he does good work, but I’ll be ready to unsubscribe if things take an unsavory turn. If he ends up in some kind of audience capture scenario it may change but for now I’m on side.

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#444

Thank you very much for your explanation. Very helpful.

Sincerely

#445

“researchers observed that microbiota that had experienced prior infection helped prevent infection with Klebsiella pneumoniae when transferred to germ-free mice. They found that infection induces host taurine production and the expansion of taurine utilizers. They went on to identify a class of bacteria—Deltaproteobacteria—involved in fighting these infections. The taurine, they determined, is the trigger for Deltaproteobacteria activity.”

Taurine might, in some cases, have a protective effect on gut infections. At this stage, I prefer taurine to fecal transplants :slight_smile:

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#446

Please enlighten me: following your comments on taurine’s 6 hour time to get plasma levels almost back to fasting ones and glycine’s 4 hours, a dosing pattern:

Glynac —4h—Taurine—6h—Glynac—4h—Taurine …

around the clock would be OK for a correct absorption levels of both compounds without interfering eack other?. TIA.

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#447

Yes. I think that schedule would be optimal for full absorption. Also remember that the quantities will also affect absorption along with any other amino acids you may ingest.

That’s why it’s recommended to take amino acid supplements on an empty stomach.

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#448

Thank you and I’ll follow your advice on empty stomach for amino acids.

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#449

… but, wait a minute, you mean any other amino acids? included those in my protein shake? :exploding_head: More schedules ahead? I am shaking, anxiety attacks! :smile:

No, now seriously, I must understand some of the amino acids contained in my protein shake bind to the same receptors as glycine and taurine? Because if that is not the case, then there is no problem, right?

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#450

There is only one other on the same pathway.

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#451

No one is on the same pathway as you, John.

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#452

So, first in the morning and on empty stomach my protein shake and taurine, go to gym, and 6 hours later GlyNAC I guess would fit then.

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#453

I believe you’re misremembering something about taking different aminos at the same time. AFAIK, no aminos’ absorption is meaningfully competitive with any other aminos’ absorption from the GI. However, some aminos do compete with some other amino acids at the blood-brain barrier: for instance, large neutral amino acids ( tryptophan, leucine, histidine, proline, and alanine) do compete for the large neutral amino acid transporter at the brain, which is why you want to take tryptophan away from other amino acids for brain effects and why the insulin surge after a meal leads to sleepiness (as for example the Thanksgiving dinner effect).

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#454

Take amino acid supplements at least half an hour before or after a meal - taking them when the stomach is empty eliminates the possibility that they will compete with the amino acids in high-protein foods.

https://www.robertjacobshealth.com/content/amino.html

This lack of clarity is likely why amino acid products instruct you to take the supplement without food, playing it safe that there will not be competition with other amino acids or nutrients for absorption, although you may also be forgoing the potential for improved absorption or action. Until more is known, you are probably best off sticking with the instructions on the label.

Also be aware that eating food can slow digestion and may delay the absorption of your amino acid supplement. This could be problematic if you seek earlier absorption to promote muscle repair during or immediately after a work-out.

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#455

Taurine and beta-alanine may not work at cross purposes to each other. From The International Society of Sports Nutrition:

“A secondary effect of beta-alanine supplementation is a potential decrease in taurine concentrations. Beta-alanine and taurine share the same transporter (Tau-T) into skeletal muscle, with beta-alanine thereby inhibiting taurine uptake within the muscle [46]. In animal models, beta-alanine has been shown to decrease circulating taurine levels by about 50 % [47]. Interestingly, Harris et al. [1] reported that 4 weeks of beta-alanine supplementation (10–40 mg∙kg−1bw) resulted in an increase in plasma taurine concentration; however, there was no significant decrease in muscle taurine content. While taurine has a number of essential physiological functions, to date there is no human data to support decreases with beta-alanine supplementation. Additionally, when extrapolated to humans, the decrease in taurine would not be of physiological significance.”

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#456

Have you noticed any changes in your levels of testosterone since you started supplementing with high dose Taurine? My T is on a higher level. I don’t know if it just is an irrelevant correlation or causative effect?

" Conclusions: The present study demonstrated that a taurine supplement could stimulate the secretion of LH and T, increase the levels of testicular marker enzymes, elevate testicular antioxidation and improve sperm quality. The results imply that taurine plays important roles in male reproduction especially in aged animals."

There is limited scientific evidence available on the effects on testosterone levels in humans. Most of research has been done on animals or in vitro. It is dificult to translate animal date of taurine supplementation to humans.

But being an aged “animal”, the data makes it relevant to keep an eye on testesterone levels.

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#457

I am a woman and just had a blood test and my doc noted an increase in Testosterone… she asked me if I am takin a higher dose of DHEA, and I said I wasn’t… so we could not think of any reason… And now after reading your comment I realize that it could be Taurine!

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#458

Thank you for sharing your observation. I am reluctant to stop Taurine. But, if needed, I will do so for a month or 6 weeks.

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#459

Why would you need to stop?

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#460

I am curious to see what happens with my testosterone, if I stop supplementing with large doses of Taurine.

#461

New positive meta analysis

Examine’s summary: “Compared to a placebo, taurine reduced (improved) heart rate (−3.9 beats per minute), systolic blood pressure (−4 mmHg), diastolic blood pressure (−1.4 mmHg), and heart failure class and increased (improved) LVEF (+5%).

The certainty of evidence was high for all outcomes.”

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