#201

I read that they gave the mice 1000 mg per kg body weight. One way to do the dose conversion is to multiply animal dose (for mice) with 0,081. That brings us to 81 mg per kg in body weight of humans. In my case 72*0,081= 5832 mg. They also saw effects when they gave the mice 500 mg taurine per body weight of the mice.(but not as pronounced as with 1000 mg).

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#202

Full text:

(PDF) Taurine deficiency as a driver of aging (researchgate.net)

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#203

FWIW

My thoughts and view increase by the amount.

#204

Okay, but I will still keep looking for research papers to find the correct dose. The papers I cited show that 5 grams daily isn’t doing much. Unfortunately, as is often the case, mouse data and results do not translate to humans.
“According to the U.S. Food and Drug Administration (FDA), just 8% of drugs tested on animals are deemed safe and effective for human use — 92% are not.”
I am not questioning the safety, just the effectiveness. There has been much taurine promoting literature and videos, but I wonder if I am taking enough.

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#205

Sorry @Joseph : what is your “view” which changes by dosage? — I went back and (although I may have reading comprehension issues) all I found was a June 12, 2023 linked article from you in Taurine which seemed to be positive (and then a comment about sugar being bad, and a question on what is HBS(?) ). Is your view positive and we should be taking 5g per day of taurine? Or do you have a safety concern. I’d love to hear your take.

I’m also still on the fence myself as it is unclear if taurine is signaling (and thus needs to be taken separately) or is a constituent for some pathway (and thus may be taken with other food/supplements). I likely strong texteat enough animal protein to get enough taurine so I’m unsure if I should be taking more.

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#206

yadav et al gave the rhesus monkeys 250 mg taurine per kg body weight, once daily.

*"To test whether taurine has health and antiaging effects in nonhuman primates, we fed aged rhesus monkeys (15 ± 1.5 years old, equivalent to 45 to 50 years old in humans) control solution or taurine [250 mg per kg body weight (T250), equivalent to T1000 in mice] at 10:00 am once daily for 6 months and then measured the health variables"

They also gave the mice Taurine only once daily.

"orally administered control solution or taurine at 1000 mg per kg body weight (T1000), once
daily at 10:00 am, to 14-month-old (middle aged) C57Bl/6J WT female and male mice until
the end of life. The dose and frequency of taurine administration was selected based on a
pilot study, which showed that when given once daily to middle-aged WT mice, this regimen increased the peak blood taurine concentrations to baseline concentrations in young (4-week-old) mice"

I find it interesting that they prefer to give taurine once daily in a large quantity. I try to take most of my taurine once daily

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#207

I guess the question that should be asked is if there is any detrimental effects of taking more than 6g of supplemental taurine daily. If not, you could boost it to 8g.

The Columbia study did research on older humans taking 6g daily and it showed positive results.

Would 8g or higher be better? Where would it turn into a detriment?

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#208

Taurine vs Rapamycin.

As always, great content Richard!

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#209

Interesting. Matt doesn’t take Taurine.

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#210

Yes… interesting because Matt says after rapamycin… he thinks taurine is the second most important thing for life and health span. Lol.

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#211

I’m pretty sure Matt is just waiting for more info to come out. Usually, it’s best to wait for the hype to calm down before the true merits of a supplement can be determined. That’s probably the way Matt is playing this.

I’m just impatient so I started already. I can’t see too much downside here.

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#212

I don’t understand why others don’t see it from this perspective, like Attia or Stanfield.

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#213

They see downside in taurine supplementation? As much as I diagonally read PA he just pointed that there might not be benefits if you eat enough meat or seafood or smth in that direction… I rarely listen to Stanfield tho…
BJ is taking 3g of taurine daily so at least there must not be any downsides from taking it since he is “the most measured man in history” :sweat_smile:

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#214

Matt must get pressure to back off of “crazy experimentation” from every angle possible in his line of work. The System would rightly worry that Matt’s personal experimentation (shared publicly) would encourage lay people to throw caution the wind. I started on rapamycin largely because of Matt’s shoulder story, for example.

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#215

Yes, Matt is very open about his experiences and his views. It’s part of the reason I respect him so much.

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#216

N=1
I have been taking 4-6 grams of taurine daily for a long time. Not really sure when I started but it was probably around 2010 when my wife developed breast cancer and I was highly stressed. No ill effects so far. It has always improved my sleep quality. Times when I forgot to re-order and was without it for a few days the quality of my sleep definitely suffered.

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#217

That wouldn’t be very useful. You’d need to eat over 45 pounds of such meat to get 6 g of taurine. And no one eating a reasonable amount of protein would have any need for extra alanine or cystine (no, this wouldn’t substitute for NAC for NAC users). And the creatine in meat is almost entirely indigestible once cooked.

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#218

Yes, your multiplication skills have proved this may not be the solution. But it wasn’t a serious suggestion: As I responded far back in this thread:

I am sure some enterprising person has figured out if combining goose liver with sheep’s heart combined with lamb shank / etc. they can get the dosing correct. But again this isn’t a serious suggestion (even though I bet this product exists), that’s not me, and not the point, and I’m not buying this product.

I am with all of many of us, with a kg bag of glycine, a kg bag of creatine (two actually because I misordered), a kg bag of beta-alanine, a pound of hyaluronic acid, NAC pills, and a kg bag of taurine coming. It seems like a lot. Hence my “thought experiment” question.

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#219

I buy citrate salts in 25kg quantities mainly so i can be sure of the chemical formula.

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#220

I would think that if two experts in the field are not taking something, you should be asking why? Rather than assuming they are wrong?

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