helenas
#21
the calculus is relatively simple for myself. While not a 1:1 analogy, the equities market makes it pretty visual. If you believe you found the next OpenAI or Nvidia, before they went exponential, would you wait for the public to come to a consensus that they are worth what they are worth? And then invest when the market cap is already extremely high? or would you get in early and get potential 100x upside, while having optionality to exit if the data starts to trend negatively? i’d rather live my life looking for 100x upsides with maybe 1x-2x downsides.
or framed another way: we can probably model what a probability distribution would look like for your life/age if you lived it according to how humans have lived for all of humanity. We have plenty of data for that. We have little data on the probability distribution for humans on rapamycin for a long period of their life. based on the current data, there is little reason to hypothesize that the distribution shifts to the left, but a lot more reason to hypothesize that the distribution might shift to the right. I’d bet on the latter hypothesis and act accordingly.
3 Likes
Spoken like a true member of the financial industry. 
Yes, the risk/reward ratio is skewed heavily towards reward with Rapamycin. The downsides are limited and short-term. Just be careful for the black swans of bacterial infection, wound healing, and sunburn. 
4 Likes
helenas
#23
more like true member of wallstreetbets
2 Likes
So you’re a fringe member then.
1 Like
I understand there is a non-zero risk assumed when taking rapamycin but it seems directionally correct to take it to improve healthspan. Do I have some doubts about the dosage, which for me at 5mg biweekly + GFJ + EVOO may be a bit aggressive? Sure. I will follow up on my LDL and likely add statin / SGLT2i / acarbose upon more research. That opens the door for polypharmacy which is not without risk as well. Do I think it is a little weird that I haven’t encountered anyone in the wild that has even heard of rapamycin and that maybe what I am doing is quite fringe? It has crossed my mind.
At this point, I don’t see a reason to stop or reduce the dose since I have no side effects and my blood work is mostly fine. If I get an injury or a bacterial infection I will know to pause taking it.
As 30s women are ovaries are “at an older age” than the rest of our bodies already. The preliminary findings from the Colombia study are very promising.
https://www.theguardian.com/society/article/2024/jul/22/drug-women-fertility-study-rapamycin
What data would you like to see that would assuage your concerns?
4 Likes
People would guess what I say on this. However, I will continue arguing my corner. I think Rapamycin is like encouraging a spring clean of the mitochondria. If someone is in their 20s or 30s, once a year might be enough (but a good sized dose at a time when not facing operations or infection risk).
The negative effect of Rapamycin is that it affects glucose processing and lipids (possibly on the back of tthe glucose), it undermines the immune system and reduces cell division.
Interestingly I think the increase in glucose levels is mainly from an increase in the baseline, not the peaks.
4 Likes
@John_Hemming my limited experience in using a CGM while taking rapamycin (13 days in total with a single ~15mg dose) was that my glucose was more reactive (higher peaks), faster to reduce (strangely variable), and maintained a higher baseline. All of this effect disappeared within 12 hours (less actually). I’d say my glucose went crazy temporarily.
I wonder if your “higher base” is from your large dose taking a while to clear…?
2 Likes
I think my longer lasting effects is because I took a higher dose. I want to wait until things have settled down before posting anything. My dose was initially higher and would last perhaps a week longer in total.
The previous dose which was equivalent to say about 50mg had calmed down before I took this dose, but I don’t have the glucose measurements to say when this calmed down.
3 Likes
@acidburn I mean, ideally I would like to see a longitudinal study in more relevant / closely related species (humans or primates) that shows life extension and no increase in specific cancers. So the thought here is if we wait 10 years till we’re in our late 40’s, we may be able to see what the effects (positive and negative) have been on the cohort here
I think the marmoset study will be published sometime in the near future - and has shown about a 10% lifespan improvement: Insights from Prof. Adam Salmon by The Aging Science Podcast
4 Likes
