Rilmenidine vs Telmisartan or other BP meds for Longevity

[adssx]

@adssx

100% Unfortunately they have the worst customer service in the world: Aktiia Reviews | Read Customer Service Reviews of aktiia.com I ordered last month. No news. I had to contact their boss on LinkedIn to get an answer that… They don’t know yet when they’ll deliver the Nov 2023 orders… Also: we need independent studies confirming that Aktiia works.

Good news for those interested in Aktiia, here’s an update on my order from Dec 29th:

[AnUser]

@adssx

However, statin alone failed and sartan alone failed (candesartan, not telmisartan though), so the combination is unlikely to succeed,

Mice mostly die from cancer so it’s not surprising to me. I also wonder how skewed the results will be in ITP toward anti-cancer agents.

[AnUser]

@Ludovic

choline rich food

Many report, anecdotes, that choline can create depression.

[adssx]

Which animals die from CVD and could be better models for statins?

[AnUser]

We already have human data. We don’t need animal studies.

[adssx]

Yes, but we also have some conflicting human data on statins and cognitive performance and PD

• The Effects of Statins on Cognitive Performance Are Mediated by Low-Density Lipoprotein, C-Reactive Protein, and Blood Glucose Concentrations 2023
• Association between lipid levels and the risk of Parkinson’s disease in individuals with diabetes mellitus: A nationwide population-based cohort study 2023
• A Comparison Between Early Presentation of Dementia with Lewy Bodies, Alzheimer’s Disease, and Parkinson’s Disease: Evidence from Routine Primary Care and UK Biobank Data 2023
• Parkinson’s Disease Progression and Statins: Hydrophobicity Matters 2022

Hard for me to reach a definite conclusion on the topic…

[AnUser]

There seems to be a small protective effect of LDL-c in mendelian randomization (0.96) per 1 SD increase in LDL for PD. But I wonder if it’s because they don’t live long enough on average to get a PD diagnosis. If you increase LDL by 3 SD to get a 0.88 decrease in PD risk you probably lost many many years of healthy life in expectation. So it’s a net harm. And there is a net benefit of 2 SD below mean, unless you maximize on PD risk.

https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.314929?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Association studies are so noisy it makes my head spin, almost any conclusion can be made.

[adssx]

Yes it’s hard. But several of my friends who are PD or AD researchers (including authors of some of the papers I cited) wonder if statins could be detrimental. It’s quite noisy for now but they’re now looking at bigger and better databases and hope to definitely answer this question (and, hopefully, they will be wrong…).

[AnUser]

Even if they are right there might still be a net benefit by using statins. It would be interesting to see statin risk on AD stratified by apoe4 status since lower desmosterol levels in brain is assosciated with increase risk of AD.

I mostly take statins because of price and availability. PCSK9 inhibitors and CETP inhibitors are coming in the next decade.

[adssx]

@AnUser

Even if they are right there might still be a net benefit by using statins.

Maybe for the general population but maybe not at an individual level depending on what you want to optimize and your personal genetic risk.

[ageless64]

Does anyone have a citation for scholarly review article on the benefits of Telmisartan, including life extension benefits. I’m going to request a prescription from my cardiologist today and I’d some research backup for my pitch : ). I’ve only found studies on specific discrete effects, e.g. insulin sensitivity, mitochondrial efficiency.

[adssx]

Many papers cited here: Why Telmisartan Is Best For Blood Pressure - Life Extension

See also my posts there:

• Angiotensin II receptor blocker (ARB) experiences? - #17 by adssx
• Angiotensin II receptor blocker (ARB) experiences? - #25 by adssx

[ageless64]

Yes, this is a good article which I’ve read. I was hoping for a journal review, which I think would be more persuasive to conventional physician. It seems it does not contain a citation to a review, only studies on specific mechanisms, which I’m not sure my physician will have the patience to read.

[Jonas]

Sharma AM. Telmisartan: the ACE of ARBs? Hypertension. 2006

[ageless64]

Thanks you Jonas and also adssx

[Jonas]

@Jonas

Sharma AM. Telmisartan: the ACE of ARBs? Hypertension. 2006

good luck! also this one: Cardiovascular Diabetology volume 11 , Article number: 32 (2012)

What is a preferred angiotensin II receptor blocker-based combination therapy...

[ageless64]

[quote=“Jonas, post:37, topic:11670”]
Telmisartan: the ACE of ARBs?
[/quote] is refreshingly pithy and hints at some appealing mechanisms for telmisartan’s longevity impact, such as reduced abdominal fat, improved fat oxidation, mitochondrial health etc.

So got my script after some conversation with my cardiologist. He didn’t think I really needed it but admitted it could be justified base on guidelines.

[desertshores]

FWIW: I like the combo of metoprolol and temisarton.

I take metoprolol in the morning and telmisartan in the evening.
Metoprolol seems to be prescribed by most doctors for old people with high blood pressure.

Metoprolol and telmisartan work differently to lower blood pressure:

Metoprolol is a beta-blocker medication.
It works by blocking the effects of epinephrine and norepinephrine (adrenaline and noradrenaline) on beta receptors in the heart and blood vessels.
This reduces heart rate, cardiac output, and blood pressure.

Telmisartan is an angiotensin II receptor blocker (ARB).
It blocks the binding of angiotensin II to angiotensin I receptors, which prevents blood vessel constriction and lowers blood pressure.
It also reduces aldosterone secretion, causing the kidneys to excrete more sodium and water, further lowering blood pressure.

[LaraPo]

I take labetalol, 50 mg, and telmisartan, 20 mg. Works very well for me.

[DeStrider]

Somehow my mother has reduced her BP from 150 to 130. The only things she’s added are GLYNAC and Taurine. She’s also been hitting the gym with my father. However I didn’t think either affected BP that much???