I’m in the same boat as @CTStan re GR7’s ingredients. Nothing really convincing to justify spending that much money. But @Colin_Willis reported positive results with it so it may be worth trying. Some before and afters would be good.
The TM5614 looks and sounds promising given its a PAI-1 inhibitor which has been reported to reverse gray hair in lung cancer patients. But I can’t help but wonder if the gray hair and cancer was linked and once that underlying issue was being corrected at the cellular level hair repigmentation followed? In any case using immunosuppressives for the sole purpose of hair repigmentation seems rather risky without further research on it (hence waiting for Eirion to undertake their trials). On the Dicord dicussion board there is a claim that Eirion is using the same albeit slightly less potent TM molecule for its own AA and gray hair reversal trials. There was supposedly a group buy for it recently as well, although no results seem to have been reported. I’ve only briefly gone through the (lengthy) Discord dicussion boards as most of it is centered around AA and that isn’t yet an issue for me, so not the main focus for me personally. It may be worth engaging in the Discord to find out more - first hand user experiences etc.
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cl-user
#402
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Haven’t heard of it until now but it looks like it acts similarly to Palmitoyl Tetrapeptide-20 aka “Greyverse” , an alpha-melanocyte stimulating horome.
Can’t find anywhere to purchase in US. Seems more common in Europe. Ended up ordering some from a supplier in Italy, but have no way of verifying authenticity of product?
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USA has many FDA hoops to jump through before market approval and commercialisation. It’s discussed a bit here:
You could always reach out to the supplier and ask for infobon the source. But the site specifically mentions it’s the trademarked brand so presumably they’re using Sederma’s Silverfree unless they’re falsely advertising.
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sev
#407
Hi dhanny. Have they said if they are doing clinical trials to verify safety and efficacy at this time? This product looks quite promising.
Do you mean FDA trials for Greyverse? Not that I’m aware of. But you can still buy products that contain it in the US they’re just not FDA approved.
Bezesk
#409
I’m pretty sure it won’t work. Looks like only cancer meds or immunosuppressants might help. I think topical BMS-202 is our best bet.
Harvey
#410
What are the potential side effects of using BMS-202?
This is an anti-cancer drug, so the side effect is reversal of grey hair. This is the writeup that got people excited about it: Hair Repigmentation During Immunotherapy
In cancer treatment I think BMS-202 is being investigated as an anti-cancer drug taken orally. I think people are planning to use it as a topical agent to see if we get the same results as oral, but without the systemic effects. I don’t think we have enough information to know if there are other “side effects”, but I’m thinking that as a topical drug the side effect risk seems pretty low (but I’m not a dermatologist).
See discussion and links here: Group Buy for Hair Loss, Gray Hair Reversal, and Anti-Aging
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@Bezesk There are a few links to studies either in this thread or on the Rapamycin for Hair Growth and Hair Pigmentation thread that seem to support the efficacy of a-MSH’s as a topical agent to help reverse gray hair. But the success stories seem far and few between so I agree that immunosuppresants are likely the best way forward. There just isn’t data/ info on their application specifically for hair repigmentation with control groups to support their safety at this point. Hurry up Eirion!
Bezesk
#413
I’ve been using a hair lotion with palmitoyl tetrapeptide-20 and Melitane for years, and it’s not doing the trick. And it seems like the guys trying out topical rapamycin aren’t getting their full hair color back. As for TM5614, it helped someone get some color back, but it wasn’t a game-changer. I want my hair color back now, not in decades when new treatments might be available. So I’ll give BMS-202 a shot.
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@Bezesk - love it. Maybe a combination of treatments? Pease document your experience.
Actually, to be clear, from what I’ve read on and understand from this thread and the other “hair growth/color” threads in this forum:
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many people here have tried simple topical Rapamycin to regrow hair and to restore hair color, and it appears to mainly be a dud (I mean ONLY Rapamycin topically in some medium such as DMSO).
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And people who are taking Rapamycin orally don’t see meaningful hair growth or color changes unless they are taking organ-transplant concentrations of rapa.
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But when they combine it with minoxidil, finasteride, and other compounds which are well-documented to regrow hair their hair regrows (with some color), and many studies have shown that this happens without rapa, so I assume the rapa might benefit skin quality/etc but may not really be doing much for hair regrowth nor color. (I’m sure @Agetron and @desertshores may have better insight)
This isnt an n=1: it is only a voracious “literature reading” of the posts on this and other threads. Is this correct?
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AndyR00
#416
What is taking Eirion therapeutics so long to start clinical trials? Funding issues? They have a patent from a few years back stating that they have already tested out their ET-02 on human subjects and it worked in reversing grey hair and very well in hair growth. So as it sounds like a gold mine potentially cure for both hair loss and grey hair, what is taking so long for them to bring it to market or even start a phase 1 trial 
Bezesk
#417
ET-02 (TM5441) and TM5614 are both readily available and fairly safe. TM5614 is just a stronger version.
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Will you go topical or oral?
Bezesk
#419
I’m definitely taking it orally.
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