#341

New research shows grey hair will soon be cured - YouTube

#342

The cure for grey hair we have finally been waiting for?

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#343

And in English:

I can’t seem to find out much about the company… it seems to be a startup company and that they are right now seeking funding, so who knows what will happen. Its very early if they have not even gotten funding yet. The company does not seem to have a website (a similarly named company has one in Singapore, but they seem to be different entities).

It seems they are the company behind this product already: NEWSTEM Rx Fractional (cream) Yj Lab Co., Ltd.

More info on the “New Stem” product: Cosmeceuticals are in high demand in the personal care industry | Herald English
Here (from (Los Angeles Times Advertising Supplement): ‘NEWSTEM’ will give your skin a balance of health and beauty | Herald English

The company:

YJ Lab Co., Ltd.
▲ Brand Name: NEWSTEM
▲ CEO : Young-Jo Park
▲ T : +82-70-5102-0577
▲ E-mail : yjlab1@naver.com

YJ Lab pursues ‘gray color restoration technology’ to attract 10 billion won in investment

J Lab, an anti-aging medical cosmetics company, has begun attracting investment. The plan is to use the funds raised to conduct large-scale clinical trials and facility investments to commercialize the recently developed melanin restoration technology that can turn gray hair and gray hair black.

According to the investment industry on the 5th, YJ Lab recently selected Samjong KPMG as the lead manager and is carrying out marketing work to attract investment. The investment scale is approximately 10 billion won, and discussions are underway with multiple strategic investors (SI) and financial investors (FI).

Investors are paying attention to YJ Lab’s recently developed regenerative material that can restore pigmentation in gray hair and gray hair. Gray hair or gray hair occurs when active oxygen is not properly removed from hair follicles or the function of melanocytes that produce melanin is damaged, causing melanin production to decrease and eventually stop.

YJ Lab paid attention to this and succeeded in developing its own material that activates melanocytes with impaired melanin production function. The material is applied to the scalp and absorbed into the hair follicles, regenerating melanocytes and effectively removing active oxygen, restoring the function of the hair follicles themselves and normalizing hair color.

While existing hair dyeing products color the hair that grows on the scalp, YJ Lab’s product regenerates the cells in the hair follicles and changes color from the hair roots that grow from there. Without having to choose a product that matches your hair color, your hair will grow back to its natural hair color, with black hair changing to black, brown to brown, and blonde to blonde from the follicles. In addition, the product is developed using only raw materials that have been proven safe, so there are no side effects.

Source = YJ Lab Co., Ltd.

YJ Lab, which has completed its own clinical trial, is planning a large-scale clinical trial using the investment funds secured this time. In addition, we plan to invest in facilities to develop and mass-produce containers designed to effectively inject melanocyte regeneration materials into hair follicles. YJ Lab is developing a specially manufactured comb equipped with a refillable solution solution so that consumers can conveniently inject melanocyte regeneration material into the scalp. We plan to increase profitability by introducing shampoo products that consumers can use every day along with solution solutions.

The domestic hair dye market is increasing every year. It grew 160% from 240 billion won in 2019 to 400 billion won last year. The browning shampoo market also grew rapidly from 30 billion won when related products were first launched in 2021 to 100 billion won last year. The growth of the hair dye-related market is believed to be due to the elderly’s desire to extend their economic activities and the increasing number of young people in their 20s and 30s with gray hair or gray hair.

YJ Lab was founded by CEO Park Young-jo in August 2015. CEO Park has been working in the cosmetics industry for over 15 years and has focused on technology and product development in the skin and hair loss fields. YJ Lab Chief Technology Officer (CTO) Dong-seop Shim, who is in charge of core technology development, graduated from the Department of Molecular Biology at Seoul National University, completed a master’s and doctoral course at Korea University Graduate School of Medicine, and has worked in medical cosmetics product development for over 25 years, including serving as a project manager at Janssen Korea. .

In addition to the hair-related products developed this time, YJ Lab supplies previously introduced medical stem cell culture medium mesosolution products, lotions, skins, creams, and ampoules to about 2,000 hospitals and clinics across the country. Another advantage is that it has a stable sales structure.

A YJ Lab official said, “We are considering attracting investment from investors in various ways for the purpose of commercializing hair solutions using melanin restoration technology.”

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#344

Sorry I meant to translate it, sounds a bit too good to be true. I can’t find a website or anything for YJ lab. Would like to find out more info about it, the raw material being used and how often it needs applied, time frame for large clinical trial and commercialision.

#345

Having worked in many startup tech companies… I know that the timeline is highly dependent on when and if they get funding. We’ll see what happens. It sounds interesting.

#346

With the hair color market on the rise I am hoping that is a good sign that they will be successful in their funding and having done their own clinical trial already and proven efficacy and safety then hopefully breeze through their large clinical trial. Fingers crossed for them as if they are true to their word this could be a game changer.

#347

Also I don’t think it is a start up as it opens saying YJ lab is an anti aging medical cosmetics company founded 8 years ago

"YJ Lab was founded by CEO Park Young-jo in August 2015. CEO Park has been working in the cosmetics industry for over 15 years and has focused on technology and product development in the skin and hair loss fields. YJ Lab Chief Technology Officer (CTO) Dong-seop Shim, who is in charge of core technology development, graduated from the Department of Molecular Biology at Seoul National University, completed a master’s and doctoral course at Korea University Graduate School of Medicine, and has worked in medical cosmetic product development for over 25 years, including serving as a project manager at Janssen Korea. .

In addition to the hair-related products developed this time, YJ Lab supplies previously introduced medical stem cell culture medium mesosolution products, lotions, skins, creams, and ampoules to about 2,000 hospitals and clinics across the country. Another advantage is that it has a stable sales structure.

A YJ Lab official said, “We are considering attracting investment from investors in various ways for the purpose of commercializing hair solutions using melanin restoration technology.”

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#348

This, however, is another thing that is targeted on fixing a symptom of age based change rather than reversing the age based change.

My experience with hair is that although you can improve the cellular environment such that new hair follicles develop and produce pigmented hair actually getting hair that is strong and white to change to pigmented is hard. I have managed whilst deminiaturising a follicle to get an initially vellus hair to become pigmented, but not one that is strong and non-pigmented.

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#349

There are various studies that have shown snow white hair regain pigmentation, mostly through cancer therapy drugs but still shows it is possible. Anti interlukin 17 therapy on a psoriasis patient and another on lung cancer targeting Anti PDl-1 that’s the two I cam think off the top of my head but I know there are a few more studies.

#350

Did those have individual hairs switching from white to pigmented?

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#351

I found 1 such on the side of my scalp near my ear, thick coarse white turning black again (as opposed to the many fine depigmented hairs getting colour again)

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#352

Thanks. It may be that this is rare.

#353

Having had to deal with androgenic alopecia myself, I have tried pretty much everything. I spent tens of thousands of dollars trying new treatments, injections, topicals etc… The truth is nothing will work until you block DHT. Once DHT is blocked in the scalp then pretty much all hair follicle stimulants will work. In androgenic alopecia as in its name, you need to block the androgen first and foremost. If you do not reduce the levels of DHT in you scalp , then whatever growth you get from minoxidil or stimulating treatments, will just fall out as the DHT will miniaturize that follicle.

People also tend to forget, that hair loss can be caused by a dozen of vitamin and mineral defficiencies. So have your levels of Zinc, Se, etc… checked.

Step 1: Block DHT (I don’t recommend any oral finasteride or dutasteride as there is no need to lower DHT systemically in serum. The problem is only in the scalp. Plus if you are trying to do everything for longevity it is quite stupid to be lowering DHT in your serum which is extremely vital for fertility, libido, mental clarity etc…)

Rx: I have done Dutasteride mesotherapy once every 3 months, mixed with silica and amino acid complexes. This is by far the most common treatment (recommended by hair surgeons and dermatologists in EU) for androgenic alopecia than oral medications in Europe. Absolutely no systemic risk. In my previous posts I posted all the research for this. I also apply some Non steroidal anti androgens topically (RU-58841). Have been doing this for 2 years.

Step 2: Hair follicle stimulants: Once we blocked DHT on the scalp and we know it will no longer cause futher hair loss or bulb miniaturization, we can now apply stimulants. Pretty much anything works for angiogenesis.

Rx: LLLT, PRP, Adenosine + Caffeine (Adenogen by Shiseido), Microneedling, Rosemary oil, Ketoconazole shampoo, Topical minoxidil (although I do not recomend topical minoxidil for several reasons some of which is the extreme shedding, scalp irritation…) I definitely would stay away from oral minoxidil as it is harmful. Read the research, case reports and anectodal evidence.

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#354

I think what DHT does is to cause damage to the mitochondria. Hence as that damage is repaired then the follicles start deminiaturising. It is, however, very slow.

OTOH I am doing this without Dutasteride or finasteride.

#355

Yes especially the 60 year old with psoriasis his hair was completely white and 6 months with anti interlukin 17 therapy hair was almost completely black

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#356

The opposite is the case. Testosterone is important for fertility, libido etc. while DHT at most plays a role in puberty but has likely no role in adult males. 98% of people using either oral finasteride or dutasteride report NO side effects. In fact, blocking DHT may be beneficial for longevity as it can lower prostate cancer rates.

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#357

No. Testosterone converts into DHT (which in its name is Dihydrotestosterone) via 5AR. Hence increasing Testosterone automatically increases DHT via the 5AR type 1 and type 2 conversion. DHT is also the more potent androgen.

Having androgenic alopecia does not mean your serum DHT is high or abnormal. Actually most people with androgenic alopecia have normal DHT levels which do not need to be corrected. So why take finasteride or dutasteride to butcher your DHT if it is in normal range? How do you know you will even get prostate cancer if all your markers are in good range and DHT is normal?
Serum DHT has nothing to do in androgenic alopecia as the problem is in the scalp. It just was observed that by reducing your serum DHT by 90% via dutasteride or finasteride you will obviously have some hair growth because the total DHT in your serum and therefore your scalp is now less. This can be achieved by a local injection in the scalp, no need to alter serum levels. It is all in genetics and specifically the sensitivity of hair follicle to DHT. There is no need to lower serum DHT if it is in normal range. Unfortunately, this is what people confuse.

A theory put out in the literature behind why most people on finasteride and dutasteride do not report significant side effects is because their baseline testosterone is already low. A large portion of the male population have low testosterone. There are many studies showing the decrease in testosterone in men over the years. Hence, reducing the DHT in those individuals will not cause the same level of sexual side effects compared to reducing DHT in someone with higher testosterone.
Individuals with lower baseline testosterone levels may be less susceptible to these side effects because they have less DHT to begin with, which means the severity of sexual side effects is obviously less.

In regard to prostate cancer, lowering DHT levels thorugh finasteride may reduce the risk and severity of prostate cancer but could also affect other aspects of your health, such as sexual function, bone density, and muscle mass, mental function etc… You cannot ignore those side effects.
There’s a reason it is taught in med school to be very careful with the balance of hormones and to not alter them if not necessary.

Ultimately, it is your decision. Most people with a clear understanding of endocrinology and the importance of DHT , advise to stay away from reducing it. Post finasteride syndrome is real, anhedonia, loss of libido, erectile dysfunction, loss of mental clarity, etc… is all case reported side effects.

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#358

Yet inhibition of DHT does not affect muscle mass
5α-Reductase inhibition does not adversely affect muscle mass | Nature Reviews Urology

So why take finasteride or dutasteride to butcher your DHT if it is in normal range

Because it is not “normal” in certain tissues like your hair follicles or your prostate. Inhibiting DHT by over 70-90% does not negatively impact 98% of men so why not inhibit it systemically using a 5ar inhibitor? Even topical finasteride goes systemic because of molecule size.

Why most people on finasteride and dutasteride do not report significant side effects is because their baseline testosterone is already low.

In the first studies done in the 1980s, did 98% of men have low testosterone?

Individuals with lower baseline testosterone levels may be less susceptible to these side effects because they have less DHT to begin with, which means the severity of sexual side effects is obviously less.

That doesn’t make any sense. Inhibiting low DHT somehow doesn’t cause side effects but inhibiting high DHT does? Besides, 5ar activity is independent of testosterone levels. There are men with both low testosterone and high DHT levels because they produce more 5ar enzymes.

but could also affect other aspects of your health, such as sexual function, bone density, and muscle mass, mental function etc… You cannot ignore those side effects.

Inhibiting DHT does not affect muscle mass and only has a low risk of causing sexual side effects (which include things like libido too).

Ultimately, it is your decision. Most people with a clear understanding of endocrinology and the importance of DHT , advise to stay away from reducing it.

You watched the podcast of Huberman who talked about the topic of hairloss (something outside of his field of expertise), didn’t you? Because current research does not support this stance at all. We have over four decades on research on the effects of DHT and inhibiting it after all.
The fact is, 5ar inhibitors are well tolerated, safe and effective at protecting your hair and prostate.

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#359

I’m not even going to start to dissect this. I can provide studies and we can go back and forth.

Again, then why inhibit it systemically, if it can be inhibited locally. Hair loss is not a terminal illness which needs to be treated aggresively and risky using pharmaceuticals which are used to treat prostate cancer. Or the strongest antihypertensive drugs. Be logical. Prostate cancer usually isn’t even that aggressive in many cases and can be treated with direct cryotherapy. I don’t see the trade off to ruin your serum DHT levels by 70-90% levels when you are in your 20’s + only to POSSIBLY prevent prostate cancer (which is also influenced by so many other factors) by the time you are 60 especially not knowing if you are going to even get the prostate cancer.

I found when I stay in the US, the usual hair surgeons + dr’s preach the same crap which is use a oral tablet with the maximum effective dose and your problem will be gone. When I go to the EU they say the opposite of lets try the minimum effective dose approach and only inject it locally. We are going to have to agree to disagree because I’m not going to spend all day going back and forth.

Honestly, Have you even tried or researched dutasteride mesotherapy?
It does wonders over oral finasteride/dutasteride with 0 side effects and more adherence to protocol as it needs to be done once every 3 months. I am saying from experience of trying both.

The only middle ground I would agree with you on is if someone is stuck on taking finasteride then possibly in the worst case, taking low dose finasteride of 0,2mg rathern than the 1mg or more could be justified.

I haven’t watched it as I’m not really a fan of his videos. If that’s what he said, then you don’t need to specialize in a field to call out bullsh** when you see it. People can read the research and make conclusions for themselves. Ultimately, we are not going to have any influence over what people do. I would say he would have a better understanding than most on endocrinology coming from a neuroscience background.

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#360

Have you considered alfratadiol (17-alpha-estradiol) by any chance? Like finasteride, it is also a 5α-reductase inhibitor, and has recently gotten attention for its effects on promoting lifespan in male mice. However it has longer history of use as an OTC topical medication in Europe for treating hair loss (i.e. androgenic alopecia). As far as I am aware, the potential side effects are very mild especially compared to finasteride (hence it does not require a prescription in many countries).

I’d be wary of using finasteride, even as a local injection, due to its potentially serious side effects as you’ve noted. I haven’t heard of finasteride being used as a local injection into the scalp before, and my concern is that some portion could diffuse into the brain.

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