Radiata
#261
The premature graying in humans probably applies more to later age graying than does the RiverTown mouse study. After all, the mice had radiation induced gray hair. Ironically, the measurement unit for ionizing radiation applied to the mice was…the Gray (Gy)
Might be worth a try with Melitane. It looks to be around $16 per 60 mL box on IndiaMart.
3 Likes
Can you remind me what you ended up using to disolve everything? Did you use DSMO, Transcutol, or alcohol / propylene gylocol, ethanol, etc.?
Radiata
#263
I used alcohol/propylene glycol/water as described in the paper, and accidentally flipped the ratios for water and PG on my first batch of solution than what was in the paper. I plan to fix it on the next batch, but suspect it may not be critical.
3 Likes
Gus
#264
Sorry to hijack the thread here but what is everyone’s thoughts of using minodixil for male pattern baldness (early 30s and STRONG family history lol) in someone who had gynecomastia in the past? This is the main reason why I’m hesitant using Finasteride as the link is more clearer. Thanks in advance.
2 Likes
Agetron
#265
Used 5mg finasteride since my early 30’s… now I am almost 65 years… never any issues… hard male chest… 
Take Anastrozole once a week past 3 years for my TRT. Still no issues.
Have used 5 mg oral Minoxidol since May… no problems.
4 Likes
I finally feel comfortable to share my hair regrowth pictures. This is after 5 months of using @Agetron 's hair tonic with EPGC.
September 2022
今天
Still room to grow!
7 Likes
Pattyg
#267
Awesome news, it would simplify things I was just reading this thread wondering if I would be able to figure out how to make the topical. I have been on the oral almost 3 months.
1 Like
Agetron
#268
Damn Chris - keep it up!
In comparison - my hair is now more brown, bronze, blonde… very natural streaked hue(s) which is what I like best about the tonic. My grey very subtle now.
Aging and hair loss - a constant battle.
1 Like
i’ve been using a homemade mixture from the original paper for 4 months but see no results at all. i have plenty of hair just wanted to test the repigment part. it could be that my concoction isn’t the correct formula as i am pretty amateur in the chemistry dept. meanwhile, i found a compound pharmacy that makes prepared rapamycin skin cream that makes my face feel amazing. i may ask them to try to recreate the hair treatment and try that
4 Likes
Radiata
#270
That’s a bummer. Were you applying it once or twice per day? How large of an area were you applying it to? Did you have any side effects such as vision problems or fatigue/drowsiness?
1 Like
DrM
#271
Add a little micro-needling, and you’ll have a full head of hair
3 Likes
sol
#272
Tell us about your compounding pharmacy, please? I’m curious about your skin cream. Is it Rx?
1 Like
Doyle’s pharmacy Houston713-526-1771. yes you need a script -comes in two strengths: i opted for 0.1% topical cream.
4 Likes
RapAdmin
#274
More on the Gray Hair topic - new research summary:
4 Likes
Anon1
#275
According to this Reddit post, clinical trials will be starting this year.
Eirion Therapeutics has a novel treatment entering clinical trials in 2023 that has already been shown to work in humans. It reverses both AGA and hair greying. Hair growth is reported to be 3x that of minoxidil in just 1/3 the time. What’s more is that this drug is not only considered safe, but has anti-aging benefits as well. It works by sequestering a protein called PAI-1. There are a small number of humans who have a mutation which reduces production of this protein, and they live 14 years longer than their contemporaries on average. Here’s a link to Eirion’s website.
Pipeline
4 Likes
Sirt6
#276
Is this about rapamycin on hair or some other compounds?
This is another company working on gray hair reversal, a new drug:
http://eirionthera.com/
2 Likes
Pattyg
#278
Who was able to give you a script?
I believe that any formulation with rapamycin requires a prescription in the US.
May I ask if you ever got around to trying this out?
I am thinking of trying cyclosporine & tacrolimus only based on @Radiata 's experience with drowsiness, since I already use minoxidil and can apply it separately.
