One thing about “forums” is that you will see more negative “results” than you will beneficial results. I see it all the time with respect to GLP1’s and yet I have over 100 people using those (Tirz and Reta) with zero long term complaints.
I did see some (4 people) with minor issues early on. The first 3 months these peptides are making significant changes to the body in adapting to GLP1’s but after that, all complaints went away. Some of my clients have been using GLP1’s for 2 years now.
I used my usual guinea pigs to try the first doses of Cagrilintide, my wife, my son and myself and none of us noticed any fatigue. We each took 1.0mg on Sunday along with our usual Reta maintenance dose. The max dose is 4.5mg per week for weight loss.
I will be starting people at 0.5mg per week in combination with either Tirz or Reta
Having said all that, there will be people with side effects to Cagri but a few vocal people on chat forums is not statistically significant when you consider the size of the trials that have been conducted on this peptide.
I do hang out on a number of peptide forums to evaluate potential issues and that has helped me modify my process for new GLP1 clients. I start below the clinical starting dose, I help people understand this is a life time process and to be patient with the process. I also do not make the huge jumps in dose as indicated in the clinical guidelines.
Low and slow wins the race, kind of like good BBQ 
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Davin8r
#144
Compared to side effects from other peptides, I see far more complaints about significant fatigue and sleepiness from cagri than from the various GLP meds, on the same forums. It’s widespread. It’s too common and widespread for me to dismiss casually. And we know that pharma studies often downplay/underestimate the true incidence of side effects.
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I’m not a big fan of this side-effect that I’m currently experiencing on 3.5 mg/wk. Did it ever improve/go away for you? Loving the appetite suppression and fat loss though.
LukeMV
#146
No I’ve just accepted it as a necessary evil. I hate it too and use 15mg ivabadrine (7.5 BID) to help offset it (I’ve been mixed about it in previous posts of mine) and it does lower it a bit but not low enough to go back to baseline
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Yep, I’ve been mourning the loss of my low heart rate hahaha. Went up by at least 12 bpm, adn now my watch thinks my vo2max is trash.
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That’s unfortunate. I’d rather not have to add another drug just to bring my RHR down…
I run a higher TRT dose than most, at 300mg/wk, but I think I can mitigate most of the risk with the following stack:
Telmisartan 80 mg daily
Eplerenone 25 mg daily
Empagliflozin 10 mg daily
Nebivolol 2.5–5 mg daily
Rosuvastatin 10 mg daily
Ezetimibe 10 mg daily
Rapamycin 5-7 mg weekly
I see a lot of people on social media having various issues with GLP1’s, most commonly “plateaus” or “stalled”. Some with the tiredness, and the other common side-effects that go away over time.
On social media, very few offer the correct advice on how to “fix” those issues so they dance around the reality (increase the dose) and offer a lot of weird and ineffective solutions. Cagri is becoming one of those “solutions”, it works but it’s not a crutch.
The MOST important thing to know about GLP1’s is that they are dose dependent. I see people who stall at 6 or 7 or 8mg of Tirz and complain about that. They have not even maxed out the dose yet. They are not “stalled” they have reached the homeostasis point of the dose they are using.
Because GLP1 performance is dose dependent, the bathroom scale is how the dose is managed. It’s one of the great things about these peptides, you can easily measure your response on a daily basis and use that data to mange your dose.
Tirz dose range - 2.5mg to 15mg per week
Reta dose range - 2.0mg to 12mg per week
Cagri dose range - 0.5mg to 4.5mg per week < in conjunction with Semaglutide when used for weight loss. It’s lower for T2D.
If someone is stalled/plateaued I always these questions;
- what is your current dose
- how long have you been at that dose
- are you following the correct once weekly clinical protocol
- how often do you weigh yourself (min 3 times a week first thing in the morning)
- Have you improved your diet
- Have you increased your physical activity
- Do you plan to increase your dose
What I commonly see on chat forums is a mish mash of poor advice and the new one is to add Cagri. While is is a great peptide, it’s an adjunct, not a base therapy. While it can on it’s own promote weight loss, it’s no where near Tirz or Reta in performance on it’s own.
In my opinion Cagri is a last resort for people using Tirz and Reta who have maxed out their dose. IMHO Cagri should not be used as a “stall” buster with doses of Tirz or Reta that are below the max.
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I think people increase their dose too early a lot of the time. Even though they might still be losing two pounds a week at 2mg, they go the next dose up because it’s on the schedule and screw themselves over on the long run.
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I agree, I don’t follow the “schedule” we encourage people to be happy with 1lb per week and maybe 1.5lb. Low and slow is the way to go.
We often bump people 0.5mg per week but rarely 2.0 or 2.5mg as it’s not really necessary if one is looking for a long term lasting solution.\
I lost 55lb in 11 months, easy peasy, never went over 3.5mg and now maintaining on 2.0mg. Currently around 138lb’s down from 199lbs 2 years ago. Total weight loss is now at 61lb, without any issues.
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