#25

Interesting indeed. Did you come across any risks or side effect that people mention?

Might be good to have a strategy around how quickly and in what context to step down supplemtation if you are in situation when you actually need your body’s inflammation response btw.

1 Like
#26

@Neo, Yes, I hope to find out whether these Amazon supplements have any resolvins at all, and whether these resolvins can actually resolve a case of aggressive inflammation, without completely suppressing the immune response. This seems like a question that will remain unanswered for years.

2 Likes
#27

In the Berry Sears video, posted by JuanDaw

Sears, states that using aspirin with fish oil would enable one to use larger doses of fish oil and it could then have even larger synergies in reducing inflammation.

Does anyone have any thoughts on optimizing the doses of fish oil vs aspirin?

1 Like
#28

Resolvin-D3-and-Aspirin-Triggered-Resolvin-D3-Are- copy.pdf (1.9 MB)

This paper speaks to the synergistic effect of aspirin and omega 3

Quote about the paper (everything below)
" The scientists discovered that aspirin triggers the production of molecules called resolvins, which help shut off, or “resolve,” the inflammation that can cause chronic disease.

“We found that one resolvin, termed resolvin D3 from the omega-3 fatty acid DHA, persists longer at sites of inflammation,” said senior author Dr. Charles Serhan of Brigham and Women’s Hospital and Harvard Medical School. “This finding suggests that this late resolution phase resolvin D3 might display unique properties in fighting uncontrolled inflammation.”

Researchers confirmed that aspirin treatment triggered the production of a longer acting form of resolvin D3 through a different pathway.

“Aspirin is able to modify an inflammatory enzyme to stop forming molecules that propagate inflammation and instead produce molecules from omega-3 fatty acids, like resolvin D3, that help inflammation to end,” said coauthor Dr. Nicos Petasis of the University of Southern California.

Resolvins are naturally produced by the body from omega-3 fatty acids, but the researchers found that aspirin magnifies their anti-inflammatory effects.

“I regard low-dose aspirin as a tonic and preventive that everyone should consider, particularly those who are at risk for cardiovascular disease,” said University of Arizona professor Dr. Andrew Weil in a statement."

8 Likes
#29

More thoughts on optimizing fish oil and aspirin.

As reported, Attia takes the following supplement stack:

  • EPA | DHA fish oil: 2.5 g | 1 g
  • Vitamin D3: 5000 IU
  • Magnesium: 1 g
  • Vitamin B9: 400 mcg
  • Vitamin B12: 500 mcg.
  • Vitamin B6 (3x per week): 50 mg.
  • Aspirin: 81 mg
  • Pendulum Glucose Control probiotic.

More specifically:

  • EPA | DHA fish oil: 2.5 g | 1 g
  • Aspirin: 81 mg

Seems like a lot of fish oil, but maybe well worth it to mitigate inflammation (as well as all the other good things it can do.

Thoughts?

4 Likes
#30

A gram of magnesium seems high. Typical of Peter though, I wonder what the form is?

2 Likes
#31

He takes SloMag, and Magtien products:

4 Likes
#32

Any feedback on that BTW?

1 Like
#33

The A. Fib issue has me dialing back the fish oil, at least temporarily.

1 Like
#34

Any update on fatty15?

1 Like
#35

Did you ever start this list?

3 Likes
#36

STEMtalk podcast with Dr. Charles Serhan. Charles is a Harvard professor best known for his discovery of specialized pro-resolving mediators. SPMs are molecules that can activate the natural resolution of inflammation and help people avoid anti-inflammatory drugs.

A paper referenced in the podcast
https://www.sciencedirect.com/science/article/pii/S0002944017301359

SPM product mentioned in podcast

IMG_7404
IMG_74041170×1801 145 KB

2 Likes
Physionic Resources
#37

G’day @约瑟夫_拉维尔,

I’ve continued taking Fatty15 from early this year and I have two months stock left which will take me to nine months of continual use at two capsules each day. Last week I pulled my subscription because my recent blood works, although fine, show no tangible benefit nor do I notice any other positive results. That doesn’t mean to say it doesn’t work but it’s expensive and there are other things I think are more promising to add to my minimal stack.

I halved by O3 intake during the Fatty15 use which I’ll now return to. As I’ve mentioned previously, I try to keep my supplements to a minimum. Certainly anything experimental I do one at a time to avoid polluted results.

3 Likes
#38

@JazzMann have you had an omega index test before or after? Thanks.

1 Like
#39

Not yet. Hard to get it done in Aust but I’ll look into it again.

2 Likes
#40

@JazzMann OmegaQuant has a mail order test that’s good.

3 Likes
#41

Thanks Joe, I took a look at their tests and they look interesting. The $99 version gives a full fatty acid report and includes: Eicosapentaenoic which I know is EPA and also includes Docosapentaenoic-n3. I think this is pentadecanoic acid AKA Fatty15.

I’m in the Europe atm but I’ll try to get the test kit sent to my home and test when I get back.

1 Like
#42

I think Fatty 15 is called pentadecanoic acid

Docosapentaenoic-n3 Sounds more like something like DHA?

1 Like
#43

Foods we love: Sardines - Levels.

A 3-ounce serving of canned sardines delivers about 740 milligrams of DHA and 450 milligrams of EPA—nearly four times the minimum recommended amount. For comparison, a typical fish oil supplement provides about 1,000 milligrams of fish oil, containing 120 milligrams of DHA and 180 milligrams of EPA.

2 Likes
#44

More on the SPM front. This time from the OmegaQuant people

1 Like