#5

I don’t believe any meaningful whole body rejuvenation or age reversal is possible and has ever happened. That said going forward you may be able to a degree slow down aging through calorie restriction and / or rapamycin.

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#6

Hi Elizabeth! Welcome.
I’m almost 52 and have been on Intermittent Rapamycin Therapy for over 4 years. I have given dozens of speeches and presentations to folks in my local Toastmasters Club, and a few other speaking opportunities. I also tell anyone who will listen about Rapamycin. Outside of family, I’ve only convinced 3 people to start their Rapamycin journey and two of them were MDs in “cosmetic practice”.

The discussions always went something like this: “how old do you think I am?” 42 and 44 were their answers.

Rapamycin “Slows down time” (M. Blagoskionny)

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#7

What dosage do you use for your hair?

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#8

Search the site for discussion of this.
I add 8 mg Rapamycin powder from a compounding pharmacist to a month’s supply of Minoxidil.
It hasn’t completely restored what I have lost in my 72 years, but it has taken me back maybe 15 years.

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#9

Where do you get Rapa toothpaste?

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#10

At least 3 discussions on this across the forum:

I think RapAdmin started these discussions.

My latest formulation:

I use 6-8 mg of Rapamycin per approximately a month supply.

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#11

When it comes to visible you have skin and hair. I think skin is easier than hair.

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#12

In the past five years, I’ve seen visible reduction or slowing of signs of aging from, in chronological order (1) quitting alcohol, (2) starting HRT, and (3) adding strength training to my exercise routine. I feel and look better (though not necessarily younger) than I did 10 years ago. There’s also less stress in my life, and I spend more time on self-care than caring for children and aging parents.

I’ve only been taking rapamycin for a few months, so I can’t tell the long-term effects, but I have seen little to no visible results in the short term. My skin is no better and sometimes worse. But I’m taking it to reduce the risk the risk of dementia in light of genetic and familial risk, not for visible anti-aging effects.

Bridget

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#13

For me and my family it’s more like rejuvenation you can Feel. We have been taking rapa since January of 2023. I would say it slows things down for me with regard to the visible signs of aging. I generally feel like I don’t change rapidly in the wrong direction these days. I remember at one point every single day used to feel like there was a new unwelcome surprise in the mirror. One thing I think rapa did was give me the initial boost I needed to start making other helpful changes in areas like diet, exercise, stress management ect. I was running with my dogs through a field the other day and thought of how amazing it was for both myself & my geriatric chihuahua who couldn’t walk in the fall of 2022 to be sharing such a joyful time. That said we all basically look our age but just healthy for our age.

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#14

Just turned 65 and just woke up. Im hanging in there. 2 to 3mg Rapamycin with grape fruit juice weekly, minoxidil 2.5mg oral, Zoloft, Buproprion, Lipitor 1x daily. Ginko biloba, NMN and 15 other supplements daily. Regular cardio and strength exercise. I’m also fortunate to have a stable and happy life. Just had 36th wedding anniversary. I have good hearing aids and looking forward to cataract surgery in a couple months that will restore 20-20 distance vision. I try to use the tools that are currently available. I do plan on looking into any new treatments as they become available and affordable. Im strictly middle class so no big money for expensive therapy and diagnostics.

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#15

Oh, and no face smoothing used on that pic.

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#17

We are of similar age. Now it looks like you are already taking plenty of medicines, so why do you take Ginko biloba, NMN and 15 other supplements daily? Personally I’m less is more mindset as I’m always concerned about drug interactions and potential damage/burden to your vital organs like liver.

#18

Thanks for sharing - I’ve taken the same amount for just a little longer, but still have grays popping up here and there. Maybe I just didn’t have as much as good genetics as you do!

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#19

I believe that supplements add valuable nutrients and positively effect the human body at the cellular level. None of the medications I’m on improve memory. Ginko Biloba is taken primarily for that purpose. Another example is that I take lipitor, which is good at reducing cholesterol, but is know to cause mitochondrial impairment in human cells. I take CoQ10 at 200mg to 400mg because it is beneficial to mitochondria. I take fish oil because it’s widely known to be good for the circulatory and nervous systems. I also take berberine which reduces my blood glucose levels, which in the past have been over 100 mg/dL. I always test in the 80’s to 90’s now. For me, it works just as good as metformin, without a prescription.

My view is that more intervention does more good than harm, as long as obvious detrimental interactions between drugs and supplements are avoided.

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#20

Ginko is a Yanq Qi herb as part of TCM. As far as I can tell all Yang Qi herbs activate AMPK which is useful from time to time.

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#21

I had extremely thick hair as a child which DHT started destroying ever since I turned 15. So no, my genetics were terrible for balding but finasteride proved to be even more powerful than that.

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#22

Please be cautious. Also nothing can be solidly built on a belief and instead it is all science.Out of medications you taking Rapamycin is quite powerful and even though it may not improve memory, and frankly nothing can, it appears that there is some evidence in rodents that it can at least slow down decline. With respect of Ginko Biloba, there’s no conclusive evidence that ginkgo is helpful for any health condition. Although some studies suggest that ginkgo may help to slightly improve some symptoms of dementia, the findings have been described as unreliable. it has potential side effects that may include headache, stomach upset, dizziness, palpitations, constipation, and allergic skin reactions. If you have a known bleeding risk, you should be cautious about ginkgo possibly increasing your risk of bleeding. So net present value of Ginko is in my opinion negative. Out of the other supplements you mention only fish oil in moderate amounts is worth supplementing and I would be a bit cautious about berberine as well.

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#23

That may be true for a young and healthy individual, but it is not a true statement for the elderly.

"Many interventions and drugs have been shown to improve memory in the elderly.
Cognitive Enhancers
Cognitive enhancers, also known as nootropics, have shown potential in improving memory and cognitive function in older adults:

Donepezil

Demonstrated improvement in cognition as measured by the Mini-Mental State Examination (MMSE) ([1])
May be particularly effective for moderate-to-severe cognitive impairment ([1])
Memantine

Showed benefits when used in combination with donepezil ([1])
Potentially effective for moderate-to-severe cognitive impairment ([1])
Rivastigmine

Transdermal rivastigmine showed cognitive improvements ([1])
Oral rivastigmine demonstrated effectiveness when adjusted for baseline MMSE scores and comorbidities ([1])
Galantamine

Improved cognition as measured by the Alzheimer’s Disease Assessment Scale"

Comparative safety and efficacy of cognitive enhancers for Alzheimer’s dementia: a systematic review with individual patient data network meta-analysis. (BMJ open, 2022)
Comparative Effectiveness and Safety of Cognitive Enhancers for Treating Alzheimer’s Disease: Systematic Review and Network Metaanalysis. (Journal of the American Geriatrics Society, 2018)
Cognitive Tele-Enhancement in Healthy Older Adults and Subjects With Subjective Memory Complaints: A Review. (Frontiers in neurology, 2021)
Strategies to Promote Cognitive Health in Aging: Recent Evidence and Innovations. (Current psychiatry reports, 2022)
Does the combination of exercise and cognitive training improve working memory in older adults? A systematic review and meta-analysis. (PeerJ, 2023)
Cognitive Improvement with Glutathione Supplement in Alzheimer’s Disease: A Way Forward. (Journal of Alzheimer’s disease : JAD, 2019)
Small molecule cognitive enhancer reverses age-related memory decline in mice. (eLif

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#24

There is no current medication that can stop, slow down or reverse dementia, some can temporarily help a person with their memory and thinking. Further, these treatments are only effective for people with Alzheimer’s disease, dementia with Lewy bodies, Parkinson’s disease dementia, and mixed dementia involving any of these types.There aren’t yet any medications that improve the symptoms of vascular dementia or frontotemporal dementia. Moreover, for the subset of people who these medications can help only about one out of ten people will show a improvement in their memory and thinking, about one out of ten people will experience unpleasant side effects and around eight out of ten people will feel no noticeable difference. Hence, my statement that there is no memory rejuvenation (= permanent and not temporary) I believe still holds.

#25

The subject you originally introduced is memory improvement. There are things that can help with that. Period. Your statement was not correct.

As for the new issue you raised, halting or reversing dementia, there are some compounds that show promise but you are correct for now in saying there is nothing that can accomplish this.

But More importantly, there is an abundance of things we can do to reduce the odds of having dementia. Some chemical, some lifestyle. This topic is what I think most of us are discussing.

As for being careful, it is an admonition that by itself is always generally applicable, but not very useful in specific. Most of these supplements are pretty mild in small doses and can be taken on a trial basis with minimal risk. What being careful can usefully mean is balancing risk and reward and being honest with oneself about outcomes.

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