#62

Some more support for how it could reset the clock to young age

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And

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And

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#63

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#64

Full body replacement is really a non starter. Cryo worries me in so many ways. I am unsure i would want the experience of being revived and living as a damaged entity although there have been people who have got very cold and revived.

OTOH i think i understand what to do to mitigate time linked deterioration.

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#65

Isn’t that what we all (those above 15-25 or so) are compared to our younger selves?

1 Like
#66

True. There are always questions of how damaged, however.

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#67

What organs can be replaced by machines? Benefits, side effects, over organic transplant? BiVACOR artificial heart:

Professor Chris Hayward, from the Victor Chang Cardiac Research Institute, said the BiVACOR heart ushered in “a whole new ball game for heart transplants.”

“Within the next decade we will see the artificial heart becoming the alternative for patients who are unable to wait for a donor heart or when a donor heart is simply not available,” said Hayward, who is overseeing the Australian patient’s recovery and was involved in preparing the device for clinical trials.

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#68

By the editor of the piece:

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See more discussion here

https://x.com/antonioregalado/status/1904589199367430305?

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#69
#70

Disease Research Acceleration

Currently, drug development is extremely inefficient (poor predictive models, many failed drugs), costly (>$1B/successfully developed drug), time-consuming (15+ years from in silico to drug approval), and risk-averse (hard to get investments for new strategies or new indications that don’t yet have any approved treatments)

  • With non-sentient human models, we could directly test interventions for nearly all non-neurological diseases, potentially accelerating cure development by decades
  • This represents an enormous multiplier on existing medical research investments. Costs for drug development could drop 1, potentially 2 orders of magnitude. Time to approval could shorten to a year.
#71

(Maybe for another thread)

Hmm, I wonder about the usefulness of discussing these topics with humans here etc, AI’s are already about as smart as humans or smarter (e.g Gemini 2.5 Pro), or very soon are, like this year. Basically what everyone is doing here is soon replaced, and AGI/LEV/ASI etc maybe not soon after, in the good scenario.

All evidence points to this in the next few years? Or am I wrong?

Might just chill back and drink a diet coke (or pepsi) and rewatch this old documentary…

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#72

I think it remains to be seen if we are able to create a super intelligence. To me it seems very clear both based on trajectory and based on the theory that we can create an AI that’s at least as capable as the best human in all domains. Perhaps even one that’s 10, 20, 30 or maybe 100% more capable. The real question for me is if we can achieve super intelligence that’s orders of magnitudes more capable, 10x, 100x and beyond. Or is there a ceiling somewhere at or above the best human.

To be clear, creating something that is as good as the best human in all domains would be an amazing feat simply because it’s far more scalable. The amount of energy required to run AI is minuscule compared to the amount of energy required to produce the most capable human, even if we had a way to guarantee that every new human is the most capable (ie it didn’t require 1 million to find the 1 in a million person).

#73

I don’t think the LLMs actually have a model of reality that enables discovering things that are completely new.

1 Like