Rapamycin Webinar and Dr. Green

[RapAdmin]

Brad - you are a registered participant in the study right? You should have gotten an email with the link.

[lsutiger]

Following up with this post from a while back. Any thoughts on the theory behind why Dr. Green would take 12 mg on consecutive days every other week instead of just taking 24 mg on one day every two weeks?

[Newbalance]

Do you take Rapa with or without food?

[RapAdmin]

I take it with a high fat meal… Typically with sardines. Here is why

Improve Bioavailability of Rapamycin (pt 2)

Depending upon what foods you take with rapamycin, the bioavailability can significantly increase or decrease. This in turn can impact how much rapamycin you need, and in turn the average monthly cost of using rapamycin. To minimize variability, rapamycin should be taken consistently with or without food. Note: Taking grapefruit (eating the fruit or drinking the juice) with some medications can cause serious liver damage, so be extremely careful with the information below, and be sure to consult your doctor. This is not a recommended protocol for people, but is only offered here for informational purposes. What are key options to consider for how I take rapamycin? With Fatty Meal With Grapefruit Juice With the anti-fungal drug called “ketoconazole” The important points to note here…

[Newbalance]

Let’s say i am not trying to save money and i want to do 6mg / week like many people are saying they do, including Peter Attia. If i’m taking 6mg with food am i actually getting a larger dose than these other people? like, what’s standard practice wihtout introducing a bunch of other variables?

[RapAdmin]

I don’t know what the other people are taking in terms of the composition of their meal - as the link in the post I just made suggests - if its a high fat meal you’re getting about 30% greater bioavailability than if you don’t.

I think that most people taking rapamycin know this, and take it with a fatty meal - but we haven’t done a poll on this.

By the way - Peter attia is now at 8mg to 10mg per week:

From Peter’s Instagram feed:

[Newbalance]

Thanks. I guess I’ll take a read some of the studies directly and see what i can gleen from them. I know some of the mouse studies included food with their dose. I looked at the Mannick immune function paper and did not see any mention of food.

[Krister_Kauppi]

Interesting finding, do you remember which post this comment was done in? Would like to see the source.

[RapAdmin]

Its from his instagram postings, a question on the video last month where he talks about the mouth sore he’s gotten (and gets occasionally) .

[Krister_Kauppi]

Thanks, here is the instagram post: peter attia on Instagram: "The only downside I can appreciate of taking rapamycin for “geroprotective” gain… right here ladies and gentlemen."

[BrianElSueco]

@KERRY_BELL

The rationale is to get a big spike of Rapa past the blood/brain barrier in the brain to get maximum MTor inhibition.

If what Klickstein says about 5 mg of everolimus 1) shutting down mTOR completely for a few days applies to the relevant parts or cells of the brain (pericytes? astrocytes?) and 2) applies to rapamycin (which, NB, has a longer half-life than everolimus), then we don’t need the big spike.