I refuse to calorie restrict. It just sucks. GLP1 agonists allow comfortable reduction in calories, but it doesn’t feel like a restriction.
Rapamycin is great for giving us a lot of the benefits of caloric restriction without having to do it.
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Another approach to mimicking caloric restriction…
A high-fiber diet mimics aging-related signatures of caloric restriction in mammals
Open access paper:
https://www.nature.com/articles/s41467-025-61046-z
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And yet another approach to obtaining some of the benefits of calorie restriction: intranasal insulin. After several months, I can report that IN insulin decreases appetite without any of the nausea or other negatives of GLP-1. I tried rybelsus and was so sick --and lost too much weight, too fast, and got gallstones. But with IN I have lost just a few pounds and definitely feel that I am eating less --just don’t want as much food.
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Jonas
#24
How about taking a handful of barberries with your meal? You can get them on Amazon or local Iranian stores.
It says to improve digestive health, regulate blood sugar, and potentially benefit cardiovascular health
