#21

Again, has anyone found papers on this description of mtorc2?

From Rhonda Patrick:

Muscle protein synthesis (MPS), simplified:

  1. When lifting weights, MPS is halted. Afterward, you get an explosion of MPS via mTOR Complex 2 (mTORC2).

  2. The amino acid leucine activates MPS via mTOR Complex 1 (mTORC1)

So, protein + resistance training = a magical combo

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#22

So, what about Creatine? Keep reading that Creatine is well studied, good for the brain as well as muscle. Creatine stimulates mTORc1. Lots of advocates, Layne Morton and?? Attia? But Attia takes Rapa. Rapamycin down regulates mTorc1. Can someone please helpme reconcile all this? Is it a matter of just choosing between longer life (but lower protein synthesis and muscle) then take Rap/Met, versus more robust physical/muscle (then take Creatine)??? If my top priority is geroprotection, because I have family history of Alzheimers, should I take RAP or Creatine? would taking both just be counter-productive?

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#23

I found this study on mice. Claims that Rapamycin abolishes the up-regulation of MTORC1 anti-depressive effect of creatine. No mention of muscle effects though.

https://www.sciencedirect.com/science/article/abs/pii/S0009279720306505?__cf_chl_tk=W9Uzl6h1kxtvV8ZDNeK8bNdkheJnmj82LjtoaTkO7Qc-1714209624-0.0.1.1-1407

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#24

Curious if anyone has thoughts on how long after strenuous exercise one should take Rapa?

I typically have a strenuous workout on Saturday morning 9-10am. And then take Rapa with lunch at 1pm.

I hadn’t seen the above that exercise increases mTORC2. I was avoiding taking Rapa before exercise, but this makes me wonder about how long after I should wait.

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#25

FWIW: I don’t let taking rapamycin interfere with my exercise routine. If my exercise schedule coincides with my rapamycin schedule, I exercise first then take rapamycin about 2 hrs later. I don’t know if this is good or bad. I exercise in the morning and I take rapamycin in the morning.

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#26

Hello - I have been using Sirolimus for the past year and a half. I have noticed benefits of increased sex drive - it seems to enhance my bio-identical HRT. I play a lot of tennis 3-4 hrs/ day and lift weights. I have not seen any decline in my ability to gain muscle. What I have seen is a significant decline in my endurance and ability to climb mountains on bikes, skis or foot. I get winded easily whereas 2 years ago I could easily do the climbing. My blood results showed low B12 despite constant supplementation as well as low glutathione. Has anyone else had these type of problems with endurance, respiratory and low B vit. absorption?

Thank you,
Maggie

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#27

Hi, and welcome to the forums. I have heard some people talk about some level of exhaustion/fatigue the day of (or day after) dosing rapamycin (though I don’t experience that). Some others say it impacts their exercise abilities / endurance.

I think you may find some interesting discussions here related to this topic:

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#28

You wrote: blood results showed low B12

If you are taking Metformin…it can significantly reduce your B-12.

Learned this from Dr. Yelena Budovskaya… Stanford anti-aging professor.

Otherwise, I haven’t had anything negative like you’re describing.

#29

That sounds like you are over exercising - I’d be exhausted at that rate.

My fitness levels have noticeably improved whilst being on Rapamycin.
I do weights 3 days a week, 15 minutes HIIT per week and 2 hrs zone 2 cycling and 2-3 hours table tennis per week.
Your 3-4 hrs / day plus weights I think is overdoing it and you are suffering from exhaustion.

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