I have a long answer, but am at a conference for a couple of days. I hope to respond to this later.
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Thank you for responding when so busy — much appreciated.
Research supporting our findings 
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Good find!
mTORC1 活性对人类毛囊生长和色素沉着产生负调节
雷帕霉素复合物 1 (mTORC1) 机制靶点的活性失调通常与衰老、癌症和遗传性疾病有关，例如结节性硬化症 (TS)，这是一种罕见的神经发育多系统疾病，其特征为良性肿瘤、癫痫发作和智力障碍。尽管头皮上的白发斑块（白发）被认为是 TS 的早期症状，但 mTORC1 在头发脱色中的潜在分子机制和潜在参与仍不清楚。在这里，我们使用健康的、器官培养的人类头皮毛囊 (HF) 来研究 mTORC1 在原型人类（微型）器官中的作用。灰/白色 HF 表现出高 mTORC1 活性，而雷帕霉素抑制 mTORC1 会刺激 HF 生长和色素沉着，即使在仍含有一些存活黑素细胞的灰/白色 HF 中也是如此。从机制上讲，这是通过增加卵泡内促黑素激素 α-MSH 的产生而发生的。相比之下，滤泡内 TSC2（mTORC1 的负调节因子）的敲低可显着减少 HF 色素沉着。我们的研究结果介绍了 mTORC1 活性作为人类 HF 生长和色素沉着的重要负调节因子，并表明药理学 mTORC1 抑制可能成为治疗脱发和色素脱失性疾病的新策略。
Full Paper (open access)
https://www.embopress.org/doi/full/10.15252/embr.202256574
Bezesk
#446
“Translationally, our data strongly encourage one to next probe in a clinical trial whether topical rapamycin can significantly retard the graying process or even repigment graying/white hair, namely in younger individuals with recent onset of hair graying, and whether this indeed prolongs anagen duration in vivo.”
How do we get the money for this trial? Maybe we should tweet at Bill Ackman?
No need to wait - lets start getting some biohacker case studies going, which would help a lot in getting people interested in doing a clinical trial.
See @desertshores spray on approach:
I think I posted this before: 30cc Trancutol, 70 cc water, 10 mg rapamycin. Mix transcutol with crushed rapamycin tablets. Let sit overnight to dissolve the rapamycin. Add water, shake and filter. Put it into small spray/mister bottles. Use small mesh metal filters. Do NOT use paper filters.
Source: Rapamycin May Slow Skin Aging (Drexel U. Study) - #28 by desertshores
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@Agetron not sure what color Quercetin will turn your locks but may make more of them. Worth adding to the mixture I bet. https://pubmed.ncbi.nlm.nih.gov/37285263/
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Healthspan just tweeted that they are now selling a Rapamycin lotion for hair growth:
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I have been taking Quercetin as an oral supplement. Never thought of it as a topical.
You are getting good results with it I asdume?
Bezesk
#451
Hopefully, they will fund clinical trials.
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I take it orally too but haven’t put it in the topical. I will in my next batch. Interesting in the study they use DMSO too.
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While in Tokyo, Japan… I decided to go for a younger looking haircut… a fade. Why not?
Less hair to worry about… and I was told I look 10 years younger. Hmmm… now my look matches the extra biological age from rapamycin dosing. Rocking 65-years… ageless!
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Yes pyrilutamide looks promising
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Has anyone done work on or tried thymulin? It is a peptide apparently made in the epithelial cells of the thymus gland, and has potential for hair growth and is also used for anti inflammation (for major cases such as lupus or Lyme diseases).
Pdf of actual research from Australia:
jakexb
#456
Definitely a good haircut!
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jakexb
#457
Trying to catch up through the posts but couldn’t find this consensus: if hair growth needs mtor, is it better to pulse topical rapamycin or should it be applied every day?
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约瑟夫
#458
The International Spokesperson for Rapamycin.
The most interesting man in the world!
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Actually yeah, I have been a bit of an international spokesperson.
RapAdmin should be noticing a few new members to our group from France, Germany and Japan. While lecturing on American medicine in these places, kept getting asked… whats going on… you are younger looking since pre- covid. So… I share!
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You might try both approaches - take photos, 2 months on pulsed every X days, or 2 months applied twice daily?
The most effective dose (at least for Angiofibromas) was .2% and applications twice daily… but no studies have been done on hair growth, so its all guesswork right now…
When compared with placebo, all concentrations of topical sirolimus did not differ in severe adverse events leading to withdrawal. The ranking analysis suggested topical sirolimus 0.2% as the most effective drug. In conclusion, topical sirolimus 0.05–1% are effective and safe in treating facial angiofibromas in patients with TSC, with topical sirolimus 0.2% being the most effective.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025300/
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Thanks for sharing RapAdmin. I was wondering, is there a formula one can use to work out potency? Most carrier solutions are measured in ML, while pills are in MG.
As far as dosing, in this mouse study they applied every other day. Since this can be hard to remember I would choose odd days or even days so you don’t have to remember if you applied it yesterday:
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