#21

I have been on and off on 1mg/day regimen over the past 2 years. No noticable blood work changes. I am inclined to stay with the practice mainly for the reason as we age, our MTOR is chronically elevated with an ever higher baseline per Dr. Brian Kennedy.

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#22

Hi Michele,
Iā€™m a fan of LDNā€¦but I think their mechanisms would be totally different. To my knowledge, LDN doesnā€™t inhibit mTORā€¦o induce authphagy.

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#23

Thank you Dr Ross. I am taking berberine on and off and I really like it, also fucoidan and astaxanthin.

#24

Very interesting! I too havenā€™t had a cold or flu since starting rapamycin about three years ago. Not even the first sign of one. Anecdotal testament to its immune enhancement effects I do believe.

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#25

Same here. Not only cold/flu but even allergies(which used to be bad during spring) have seem to abated. Didnt use flonase for two years.
Quite perplexing though for me is that fact that IGF-1 has gone up from baseline of 74 to 114 agter nearly 7 months of weekly Rapa use!! I do 24 hr caloric fast starting with the dose.
For those of us on weekly Rapa with GFJ hack, how will daily dosing work while rationing Rapa stocksā€¦hahaaa?

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#26

Yepā€¦ it is now the season of ragweed. And, as to allergiesā€¦ nada past 3 years. Has to be the rapamycin.

Never had allergies until I hit 50 years old. I used flonase for ragweed in fall and cedar spores in spring.

I was on flonase back when it was still gotten by prescription. FYI - flonase went off prescription July 24, 2014. Over 11 years ago.

My wife first started getting allergies a bit before me maybe at 46 years. She isnā€™t on rapamycin or flonaseā€¦ and she continues to get and complain about seasonal allergies. So I know the environment hasnā€™t changed.

Rapamycin rebuilds the immune system, so I am back to my pre-50 year old immunities issues. Which were none.

Just one of my markers for rapamycin is working.

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#27

does it reduce 8oxog?

#28

Greetings
The rise in your IGF-1 levels may actually reflect better health.
See the attached reference, figure 3a, which plots all cause mortality risk vs IGF-1 level.
The curve is U shaped, with the most favorable IGF-1 level being 140.
Hope that helps

Association between IGFā€1 levels ranges and allā€cause mortality: A metaā€analysis - Rahmani - 2022 - Aging Cell - Wiley Online Library

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Rapamycin induced insulin resistance and drop in testosterone
#29

Excellent paper. Thatā€™s the kind of metanalysis I was looking for. Reassuring for me to say the least! Although, what remains unclear is how Rapa would fit in this equation for my IGF-1 trends.
U-shaped association seems intuitive just like many other nutritional markers which tend to be J or U-shaped.
Thanks for sharing it.

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#30

I still get sick even with Rapa 10 mg equivalent weekly. HOWEVER, the intensity of the illness is greatly reduced. I used to get hacking coughs that would last up to 6 months. Now they typically resolve in 1 month or less. I still get COVID every year in the Spring, but itā€™s less troublesome than the flu nowadays.

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#31

A news article on this research paper:

Ghada Alsaleh, a postdoctoral researcher at the University of Oxford, explained that rapamycin consistently produces the same effect, whether itā€™s given before, during, or after the damage occurs.

Study co-author Lynne Cox said the effect happens rapidly ā€“ within about four hours it appears to influence the DNA damage response and the buildup of lesions.

A cautious endorsement

Matt Kaeberlein at the University of Washington sees the study as strong evidence that rapamycin protects DNA. Yet he emphasizes the mechanism remains a mystery. The next step is to track how the drug changes RNA and protein activity inside immune cells.

In a pilot study, older men given low-dose rapamycin showed less DNA damage in their immune cells without harming overall immune function. This is a critical finding, according to Cox.

Even more intriguing, a longer trial revealed that rapamycin reduced senescence marker p21 while raising levels of p53, a protein that not only manages DNA damage but also fuels mitochondria, the cellā€™s energy engines. This dual action hints at improved genetic stability and metabolic health.

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#32

Ok that tears it, weā€™re going back to weekly dosing. Not ready to try 1mg a day yet but biweekly isnā€™t working for us. My husband and I switched some months ago to biweekly dosing from once-weekly and we arenā€™t feeling as good as we were. His hair is greying much faster and my ā€œI want to run instead of walkā€ is much less frequent.

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