#101

Good questions. He smoked a pipe until age 50. I heard carotid bruits when in med school 50 years ago, so he likely had some atherosclerosis then. He was indeed slim.
He started riding a bike mid 50’s.

I have no idea about his Apo A.

His mother (also slim), developed dementia in her 80’s, and his sister developed it in her late 70’s.

I suspect that the genes are not all good. I have high Apo B, high LDL, low HDL and I’m heterozygous for APO-e4.

I’m assuming of course that he is indeed my father… then again, my mother seemed to be pretty friendly with the milk-man😉. Home to think of it, a lit if the kids on my street looked related.

That said, at 70, I’m a life-long exerciser, never smoked, BP is 90/60, 12% BF, and have been on Rapa for 5 years (for another indication).

I’m stuck with high dose prednisone, and have developed a bit of insulin resistance. I started acarbose for that and sugars are better.

I’m rolling the dice regarding the lipids. I will never know if the rapa is helping or hurting… because case studies are fun and interesting, but mostly useless😉.

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#102

We will agree to disagree then. In my career, that position led to major mismanagement and patient harm.

#103

Your post made me laugh because it reminded me of my own Dad - at 90 and playing tennis yet having the Wall Street Journal delivered everyday and not being able to read it. I really appreciated that I could enjoy the companionship with him at a late age.

I understand your point, and am very indebted to all the medical folks offering their clinical experience. But I I take in a wide swath of information, whether self-experimentation from individuals or clinical science evidence. Some interesting progress has been made by medical scientists who were essentially “self-experimenters” I might add. - See Weisse AB. Self-experimentation and its role in medical research. Tex Heart Inst J. 2012;39(1):51-4.

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#104

I think this is probably a question of detail. It depends what the interventions are, what evidence there is for safety and what the evidence is from case reports and how many there are.

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#105

@Bettywhitetest I doubt anyone here has a problem with people doing self experimentation as long as they are safe and realize the accuracy of the results needs verification.

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#106

Wow. What a wonderfully detailed response! Great stuff. Thank you! I really like the idea of alternating with the fasts as well.

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#107

Only negative I get from Rapamycin is increased A1C. I am taking 8 weeks off from it to see if it resets, but I generally don’t agree with the idea of cycling because I feel that we lose the benefits of most things when we stop taking them.

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#108

Hello all - first post. Fascinating resource.

Just filled my first prescription for Rapamycin. I have a couple of questions for the knowledgeable here.

I intend starting on 1mg per week increasing by 1mg each week to 8mg cycling 8 weeks on then 4 or 5 weeks off.

Question one - do you ramp up on each cycle or do you start each subsequent cycle at the higher dose.

Second question - with or without food. I tend not to eat breakfast. I understand morning is the best time for rapa.

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#109

In my experience - I can jump back in at the same dose level after taking a break (for whatever reason, whether because you want to cycle or if you are trying other things… for example last year I did plasmapheresis as part of a study and needed to be off rapamycin for 6 months. Your mileage may vary (and I encourage others to post their experiences on this topic) but after being on rapamycin for about 5 years now I can easily stop and restart at higher doses with no noticeable side effects.

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#110

Thank you. I will try the second cycle at the higher dose and see how I go.

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#111

I had the same experience as @RapAdmin. After each Rapa break, I was able to start again with the same or higher dose without having adverse effects. I usually take 6 mg.

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#112

Thanks for your advice.

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#113

Any updates?

Thank you very much for this answer. Beautifully done @McAlister

#114

Thats very nice review! Very informing indeed.
Fasting in conjunction with Rapa has always fascinated me.
I used to perform 72 hrs water only fasts prior to starting Rapa(in Nov 2024) every 1-2 months. I used to feel great besides enhanced focus, ketosis abd hormetic stress. Weight loss was never my goal as I have had a freat BMI. But then grew concerned about some muscle mass loss/sarcopenia I couldnt overcome despite strnegth training and protein loading etc. So, I abondone it but still do time restricted eating but no prolonged fasting.
Are you still doing 24 -36 hrs fast? Do you begin to fast concurrent with the dose ingestion or prior to that? How has it been going in terms any measurable data?

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#115

I actually keep rapamycin and fasting separate. I have a five-week cycle of Mondays:

  • Week 1: Rapamycin
  • Week 2: 24 Hour Fast
  • Week 3: Rapamycin
  • Week 4: 24 Hour Fast
  • Week 5: Break

I break up the remaining six days of the week into an A/B schedule. So I take one set of supplements on Tuesday, Thursday, and Saturday and another set on Wednesday, Friday, and Sunday. On Mondays, I either take rapamycin, fast, or break (no supplements, regular eating).

The PhenoAge on my last batch of blood work put me at 13.8 years below my chronological age. My PhenoAge has remained largely stable for the past nine years, so at least according to that metric I’m paused in my twenties. I’ll have another round of blood work in the next month or so. Hoping for another stable readout!

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#116

Could you share the supplements you take on your A and B schedules? With your great PhenoAge results, you may have hit on something wonderful!

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