#11

It’s really weird that rosuvastatin at 10mg caused me side effects but atorvastatin at 40mg doesn’t at all other than feeling a bit sleepier in the evening when I take it.

1 Like
#12

Ask him - alangreen225@gmail.com

#13

@Virilius it is interesting that the effects can vary so much between types of statins…fat vs water soluble. I started in atorvastatin 10mg and immediately felt muscle aches after lifting. I switch to rosuvastatin 5mg which I thought solved it. But then I started feeling it again after lifting so I stoped taking it on my lifting days, and I doubled up on the non lifting days. That worked for a while until the symptoms crept back. Then I dropped to 5mg only on non lifting days. Again, it worked for a while. All the while my power on my bike was dropping. I thought it was weird but didn’t know what the cause was. I thought: metformin (or which I know from my past is a RPE multiplier). With metformin out of the way I thought rapamycin. I took a month off with no improvement. Then I heard about GG. Bingo. My power started coming back. Then I thought why not stop the statin and use a better tool. Goodbye statins. Good riddance.

5 Likes
#14

Thank you for posting this!

Have you considered bempedoic acid? I am thinking of introducing an intermittent dose (every other day) and measuring its effect.

2 Likes
#15

There is still controversy about lipid levels despite what @Anuser says.
The studies of centenarians I have previously posted indicate very low lipid levels do not increase longevity. It may be the case where it is beneficial to have low lipid levels in youth but not in old age.
Like you, I didn’t know that statins were affecting my subjective well-being until I stopped taking statins. My lipid markers look good just using ezetimibe and bempedoic acid.
I am scheduled to take new tests in July and will post the results.

4 Likes
#16

Low lipid levels will prevent heart disease and strokes but not cancer nor alzheimers nor any of the other age-related diseases. Moderate or high lipid levels in old age haven’t shown to mitigate those issues either and atorvastatin basically had no effect on the ITP mice one way or another.
Even assuming that we get medication for cancer and alzheimers that work as well as those that address diabetes and cardiovascular disease, something else will kill most people before they cross the age of 110-120. There is just something at this barrier that kills you even if you’ve managed to ward off all damage.

2 Likes
#17

Yes. I’m on Bempedoic acid now. I had to import it but just yesterday my doc sent in a prescription. We’ll see if insurance will pay. I’m not holding my breath.

3 Likes
#18

There might be controversy, but it’s wrong.

1 Like
#19

Based on the studies few centenarians have low cholesterol levels.

1 Like
#20

Except in Japan I guess.

The frequency of hypobeta-lipoproteinemia (apoB < 60 mg/dl) in centenarians was almost ten times as high as in controls.

4 Likes
#21

Bempedoic Acid and Ezetemibe from India (Brillo EZ) is the best solution to high lipids I have found in terms of effectiveness, price and ease of use.

I was sold on lipid lowering when I found out that when most people die of old age, it is usually a stroke or heart problem.

Also, mice and worms don’t have heart attacks, mice die of cancer so you won’t be able to see life extension for lipid treatments in mouse or worm trials.

The number one cause of death in humans is cardiovascular disease which usually strikes before 100 for those that will succumb. So analyzing centenarians for lipids is affected by survival bias.

4 Likes
#22

I think the issue here is that everyone who reach this age range currently has spent 99.9% of their life under the “sick care” regime rather than any pro-active healthcare.
We are the ones being most proactive at healthcare that have the best chance of breaking the 122y.o. barrier.
(The greater your ratio of healthcare:sickcare the greater your chances of breaking that barrier).

2 Likes
#23

Proper RYR includes a natural statin (Hydroxymethylglutaryl-CoA aka HMG-CoA reductase inhibitor) which is called Monacolin K aka Lovastatin.

However, RYR sold in the USA has the statin taken out normally, but I would check the RYR that you buy for this.

2 Likes
#24

This is what dying of old age really means.

Natural causes,” on the other hand, typically means no obvious cause of death was identified for an elderly person’s death, even though it was likely caused by a common condition, such as a stroke, heart attack, or blood clot.

So, probably CVD does in those who die of natural causes. All the more reason to keep your lipids in check.

1 Like
#25

I’m just guessing, but in a lot of cases CVD will turn your life into sickcare - stroke, heart attack, you can’t walk, talk, or think properly, so that is making it very important even if it didn’t affect total mortality that much (in the case someone had the potential to live to 100 or whatever, then it would as not only would it affect QoL but also bottleneck longevity).

2 Likes
#26

What is GG? (Can’t find it in thread)

1 Like
#27

I have excellent results on rosuvastatin 5 mg, ezetimibe 5 mg, and a-cyclodextrin once a day with morning smoothie. Just for only 1 month, my total cholesterol dropped from 208 to 184, and my LDL from 98 to 76. Triglycerides remain the same at 49.

2 Likes
#28

@LaraPo

Here’s the original thread on gg

3 Likes
#29

I am surprised to hear Dr Green is more concerned about the effect of statins on insulin resistance vs the potential downside of dyslipidemia from Rapa. My personal experience is that Rapa has significantly increased my LDL. He must have seen that in a subset of his patients and so I wonder how he’s treating that? I’ve had to cut back my use of Rapa (currently trying 4mg every two weeks, down from 6mg weekly) while simultaneously adding ezetimibe to my current statin therapy.

3 Likes
#30

I had the same thing happen with me, I have developed extreme pain around my elbows after a month on 5 mg of rosuvastatin.

2 Likes