#589

Yeah, unfortunately they don’t have any of the ASO clinical trials near me, so I have to wait and hope one comes around (which it should since I am in Atlanta).
I am on a statin right now to help with my other lipids as I have done everything else such as diet, exercise, etc. I am thankful for the forum because I caught all of this young(24) and I got a lot of good input from everyone on here.
Honestly I feel lipids are confusing for a lot of people(look at the forum on here about them lol) including Doctors , so theres a lot of confusion on what to treat and how to treat them.

2 Likes
#590

There are multiple non drug ways to keep lipids under control like
Amla
Citrus bergamot
Flax
Lycopene over 25 mg’s per day
Psyllium

3 Likes
#591

A comprehensive look at natural PCSK 9 inhibitors

3 Likes
#592

Also olive oil.
My lipids good and bad have risen since taking rapamycin, but they are still in the normal range.

I take extra virgin olive oil and lemon juice in a small glass or Dixie cup. 1 Tbs each, toss it back like a shot of tequila followed by a drink of water. Try to do this twice a day.

Oatmeal and oat bran cereal for breakfast will drop your lipids in a very short time.
I have used this time and again in the past whenever my cholesterol was getting marginal close to the upper healthy limits. The FDA thinks this is true.

"virtually all have reached the same conclusion, namely, consumption of oats and oat-based products significantly reduces total cholesterol and low-density lipoprotein cholesterol concentrations without adverse effects on high-density lipoprotein cholesterol or triglyceride concentrations.
https://journals.sagepub.com/doi/abs/10.1177/1559827607309130.

"Two tablespoons of extra virgin olive oil (EVOO) a day may decrease the risk of heart disease by improving blood levels of lipids and lipoproteins. "

2 Likes
#593

The epidemiology in PCSK9 loss of function mutation in Ashkenazi Jews with clear benefits (no known adverse health effects) seems to make it pretty clear to me frankly as a benefit vs risk.

2 Likes
#594

Statins induce an increase in PCSK 9 levels which tends to attenuate the lipid lowering statin effects. I know that Ashkenazi Jews have a mutation that blunts the increase of PCSK 9 from statins.

Ashkenazi Jews have significant longevity but they also have longer than average telomere lengths which is associated in multiple studies with lower cardiovascular risk.

2 Likes
#595

That’s true. I would also look for non-AJ in the genome library with the loss of function and normal or lower telomeres. The causation factor we can put on it is pretty high.

Not to mention, familial hypercholesterolaemia/a gain of function has the opposite effect. It appears very clear that PCSK9 has a pro-atherosclerotic effect. I think as a gene therapy target in the liver only in age 30s is pretty reasonable with minimal risks. Maybe if we find a targeted epigenetic therapy that would be slightly more desirable although vaccines would be a cheaper option.

1 Like
#596

I also take 2 Tbs a day. I buy, when available extra virgin unfiltered. Costco has unfiltered a few times a year. Unfiltered has more polyphenols.

3 Likes
#597

For EVOO it’s good to perform the cough test. If it’s high in oleocanthal it will make you cough like a strong pepper.

I spent $60 to try this out on a very high quality EVOO and in fact it made me cough 4 times. Impressive.

4 Likes
#598

Likokareas? That’s great, enjoy! Use unsparingly.

#599

I’m treating it like a bottle of champagne.

2 Likes
#600

I knew that it was supposed to burn a bit at the back of your throat but I hadn’t heard of the cough test. Thanks for that.

1 Like
#601

It would be interesting to see a long-term mouse study comparing control vs. rapamycin mice with regard to exercise / physiology / (the equivalence of mouse marathon times) over the lifespan of the mice… I wonder if peak physiological capacity is maintained at a high level for a much longer period of time, as we would expect.

1 Like
#602

Would dearly love to see that study…maybe we could sponsor a mouse, and do some online betting on the side to help fund it.

1 Like
#603

It’s a little misleading when he says age 25. A quick glance at different graphs in the study is actually closer to age 28-30 peak for men. Kind of what I was suspecting as age 25 quickly rang some alarm bells in my mind in terms of bias.

But we already know long ago that age 25-35 is the range of peak performance for athletes. It doesn’t really add much.

1 Like
#604

On the shorter races it’s pretty flat from 50 to 75. After 75 they lose steam fast. These are people that take good care of themselves. I’ve got about 14 years. More than I thought.

2 Likes
#605

I’m now wondering if taurine would be a good add on to rapamycin. In this study it had a significantly positive impact on HbA1c and insulin sensitivity.

And here we see some very impressive effects from hydrogen sulfide as a cardiovascular protective mechanism. One apparently simple way to double up on hydrogen sulfide is via taurine. Combined with NAC May give even better results.

Seems like a rather modest dose of 1.6 grams of taurine can do the trick. Downsides appear to be minimal.

1 Like
#606

There was that company/seller from outside the US that was selling rapamycin capsules {4mg of rapamycin] filler was L-taurine.

Link below

Never used, purchased or had dealings with this company.

I would try and copy.

#607

That’s inter. I’m impressed by taurine’s effects on blood sugar and cardiovascular protection. Might even give an energy boost.

1 Like
#608

I have used taurine in the past mainly for its ability to prolong uninterrupted sleep time. I would take 2 - 4 grams at bedtime. It really worked for me. Maybe I need to revisit its other benefits as I have a lot of taurine on hand.

Right now I have no sleep stack other than 3 mg of melatonin. As I have posted before, after taking relatively high doses of rapamycin for over eight months, my sleep problems magically disappeared and I have been getting a solid 7~8 hours of sleep, rarely having to get up during the night.
I haven’t seen anyone else posting that rapamycin improved their sleep. Am I a one-off?

1 Like