#304

@desertshores

Your chance of reaching 100 is about 5.7% according to this site based on your date of birth.

Centenarians have some unique genes. They have a large heritability lineage to start with, but mainly a superior ability to resist DNA damage vs mere mortals.

It’s not some lifestyle secret or LDL. Researchers been looking down this rabbit hole for forever.

Therefore, to try and distill their longevity to a biomarker panel, is purely association.

But who knows, Rapamycin might be the magic bullet!

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#305

Yes, but still maybe a better chance than you. (LOL)

#306

Same site shows me at 11.5%. Race on!

#307

MAC

Your life expectancy based on your birthdate only counts for that year.
i.e. When I was born in 1941 the male life expectancy was somewhere between 64 & 67 years old depending on where you were born. (Well, we have certainly passed that mark.)
Social Security Actuarial Life Table says I have an average chance of living to be 88 and if I live to be 88, I have an average chance to live to 93, etc…

After 90 it drops off rapidly, but for any year you live to be in your 90s you have an average of 2+ more years.

“For this table, the period life expectancy at a given age is the average remaining number of years expected prior to death for a person at that exact age, born on January 1”

Still another life expectancy test:
Thomas Perls, M.D., M.P.H., F.A.C.P. Department of Medicine at the Boston University Medical Campus Seems to think I will live to be 98 years old, but he doesn’t know I take rapamycin.

https://www.livingto100.com/
Your calculated life expectancy is 98 years.

I also believe for every additional year I live there is hope for a new and amazing life extension protocol. Hopefully, it won’t be something only the rich can afford.

3 Likes
#308

Back on the CVD and raised LDLc issue, I recently listened to a podcast interview with Dr. Steven Gundry MD who has all his patients checked out for oxidised cholesterol by checking OXplAPOb (or failing that OXLDL). He doesn’t bother treating high LDL if the oxidised levels are low.
I notice that LabCorp do an OXLDL test - I was only checking that because no-one in UK does them. That said, my MD is now trying to persuade a lab here to do it for us.

#309

It seems that rapamycin, at least in transplant patients, increases the risk of clotting.
Renal transplant patients in particular are prone to clotting and rapamycin would appear to exacerbate this problem.

https://www.thrombosisresearch.com/article/S0049-3848(20)30309-1/pdf

So the obvious question is whether this applies to non transplant people who aren’t prone to blood clots? Are we at risk of venous clots , embolisms, stroke, etc?

Once again there’s no good human data so we don’t know. We do have a fair amount of anecdotal information coming from Matt’s survey and Alan Green is treating many patients and to my knowledge hasn’t raised any red flags.

Regardless, until we know more I’ll be incorporating some natural products into my regimen that possess some anti thrombotic properties.

1 Like
#310

FWIW…look into Serrapeptase and Nattokinase, prevents and dissolves blood clots.
They have a significant anti-inflammatory, proteolytic and fibrinolytic properties.

#311

I will thanks. I’m sensitive to histamines found in fermented foods like sauerkraut . Wonder if that matters.

#312

Here’s a nice review of nattokinase

Perfect. I’m more concerned about pro coagulation and blood clotting than lipids. I don’t know if it’s an actual concern with intermittent dosing but I’d rather not chance it. It’s not a small matter.

Any brand suggestions?

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#313

I have used a product called “neprinol adf*”{this is a trade name a proprietary blend/mix] the retail cost is on the high end. I did look into purchasing the individual item{Serrapeptase and Nattokinase] and copy the formula, purchasimg this was just easier.
The capsules in neprinol are acid resistants {AcidAmor™] to deliver into the intestinal track. Is to be taken on empty stomach. If you take it with food it will help digest the food, that is not the intended use. When I do we take it I take a large amount 10 capsules at a time, I look to get 150,000 FU at a time.

*From the manufacturer;
Neprinol is a proprietary combination of serrapeptase, nattokinase, protease, lipase, bromelain, papain, rutin, amla, and other proteolytic enzymes.

#314

Lots of in vitro and some animal data with nattokinase, but this recent 3 year clinical trial showed zero benefit:

#315

FWIW, from the study posted above…“2,000 fibrinolytic units” is the amount that was used.

In my view the amount used in the study is useless. Would require tens of thousands of units, as I stated I take 150,000FU at a time.

#316

Ok, but it would still be helpful to see some actual clinical data in humans, even something basic like prolonged PT/pTT after nattokinase vs placebo.

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#317

Ten years ago I had a cardiac workup. It found I had dangerously high fibrinogen. My physician recommended I try nattokinase but it had no effect. I then tried serrapeptase and my fibrinogen dropped into normal range.
I’ve been using it ever since. I take 500 mg of Nutramedix brand every other night on an empty stomach and my fibrinogen remains in middle of normal range.

3 Likes
#318

An idea/suggestion for a quick “test” you can do yourself.

Pick up a CoaguChek{it is like a GM, except this instrument measures PT/INR]. Measure base, take a large dose and measure over time.

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#319

How many FU per 500mg?

#320

He is a cardiologist, has a very large AD at risk patient population he treats (AD being very highly correlated with the vasculature), I follow him. Indeed, oxLDL is really all he looks for re CVD risk.

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#321

No idea. From the bottle: 2 capsules is 1000 mg of proprietary blend of Inulin and Serrapeptase.
As I recall, I was initially taking 2 capsules/night and gradually discovered that 500 mg every other day was enough.

#322

Never heard of that, will have to check it out.
Were you taking rapamycin when told of your fibrinogen levels?

#323

No. I’ve only been using rapa for about 2years. I started on Serrapeptase 10 years ago.