#2483

But that puts you into faith of pharmacology and pharmacology is run by industry that has one main purpose, earn money. So some old medicines without patent (and supplements for the argument sake) don’t stand a chance to get sufficient funding and large scale studies you think offer enough evidence.

1 Like
#2484

That doesn’t mean anything to me.

So I don’t use them when there are alternatives that do have that evidence.

Compare the level of evidence shown in an EMA assessement report with those 20 person supplement studies:

Pharma is the same as supplements, just it has about 100 times more evidence of safety and efficacy.

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#2485

In my perspective, considering that rapamycin appears to elevate LDL/ApoB even in pulsatile doses for anti-aging, it seems logical to address the elevated atherogenic lipoproteins it may cause. We are certain that these lipoproteins contribute to atherosclerosis, although we currently lack human data on the potential protective effect of rapamycin, despite its promising nature. There’s a possibility that rapamycin is atherogenic through its lipid effects while simultaneously being anti-atherogenic through anti-inflammatory/antiproliferative effects. The question remains as to which mechanism prevails, and whether it is consistent across all individuals.

Effectively lowering lipids is a separate challenge, with a high-quality diet being the safest initial approach. Personally, I favor options like ezetimibe, amla extract, citrus bergamot, and PCSK9 inhibitors. While statins are effective medications, they come with a higher risk of side effects.

Addressing elevated glucose levels is another concern, and I believe it’s essential to approach it seriously. Ideally, treatment should involve reducing body fat and increasing exercise, with further steps taken conservatively if necessary to minimize the risk of side effects, as seen with lipid management.

2 Likes
#2486

Amla extract and citrus bergamot have limited amount of evidence of safety since they are supplements and citrus bergamot if I remember correctly is a dirty drug.

Statins are perfectly safe if someone doesn’t get muscle side effects, elevated liver enzymes, insulin resistance and possibly decrease in desmosterol levels especially with APOE4 allele.

edit: nevermind I am talking with a GPT spam bot.

#2487

@RapAdmin first case of a GPT spam bot on the forum above, you probably need to figure out a way to ban all VPN’s, Tor, etc from the forum and other solutions before it becomes a problem.

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#2488

Lol

image

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#2489

I don’t think we can say “perfectly safe”

There’s clearly a dose/side effect curve with statins. And I think it’s reasonable to say that exercise and diet can play a large role in reducing apob and therefore the need for statins. And that we should be looking to these first to do much of the heavy lifting.

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#2490

Read what I said, “if someone doesnt get…”

So what is your apoB from exercising and dieting?

#2491

Yes, that was my point, you didn’t include all the possible caveats, only some.

I’m not dieting, just eating and drinking. My apob is below 70 and I’m not sure why. Could be related to high fish consumption, and high garlic, flaxseed, fibre? Could be tea (green and earl grey with bergamot!). Could be linked to my occasional accidental dose of beeswax/honeycomb (im a lazy beekeeper). Could be dumb luck and genetics.

I’ve not tested post rapamycin but if it does rise, I assume there’s much more i could be doing in terms of lifestyle before reaching for statins because i don’t consciously do anything “for” my blood lipids. That’s why im in interested in this board and hearing from people who aren’t fixated on exclusively pharmaceutical interventions. For me it’s easy to not spit out the odd bit of wax when i eat my honey, so the policosanol studies are of interest.

Fwiw i think v low dose rosuvastatin + ezetimibe carries the biggest “apob bang” for your “side effect risk buck”. The dose response curve for both is quite dramatic.

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#2492

70 is still too high if you don’t want atherosclerosis.

#2493

I never had problems with cholesterol or blood sugar until after Rapamycin. However, I feel that the benefits outweigh the negatives and I hope to pair Rapa with Metformin, Ezetimibe and Bempedoic Acid to counter negatives.

I think we can assume these combinations are beneficial from the ITP results.

#2494

I don’t think the evidence is there to support targeting a lower threshold. I’m comfortable with it in the 50s and 60s because im not convinced the weight of evidence is sufficient to warrant a pharmacological intervention.

What’s your apob? And what do you take?

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#2495

1 month of rosuvastatin 5 mg and my apoB was at 59 mg/dl, I haven’t tested it since. But I will try 5 mg with 10 mg ezetimibe.

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#2496

If i read this correctly you are implying that RAPA messed up your Blood sugar and cholesterol. If that is the case I think I’d have to rethink the RAPA journey myself. To be fair i have not checked my blood yet but I will in near future but If I notice that my biomarkers are screwed up that would definitely be because of RAPA since I’ve had my biomarkers in the normal range for all of my life.

Anecdotally, I have noticed that when I do my resting period (usually one week, sometimes two) I feel amazing, much better than when I’m doing the various meds and supplements. BTW, when i do the rest period I stop everything, just food and water. By same talking I have also noticed that if I extend my resting period (done 4 weeks couple times) my ageing symptoms (fatigue, indigestion, aches, laziness etc) start creeping up again. Therefore, I intend to experiment (dosage, timing, frequency etc) for next 6 months or so and try to find what works best for me. In conclusion i can certainly say that many of the things that I’m doing (which is what everyone/most in these boards are doing) is having a really great positive impact in my overall wellbeing and health. However, the dosing and frequency seem to be a big puzzle for me that I hope to solve in near future.

4 Likes
#2497

What are you targeting?

#2498

30-40 mg/dl but 20-30 mg/dl can be good too.

#2499

Very interested to see which studies support targeting at that level.

#2500

PCSK9 inhibitor studies support it.

#2501

So you’re taking statins and ezetimibe based on PCSK9 inhibitor studies?

#2502

Yes, but there are also statin studies.
Mechanism of action is based on apoB lowering.