#2282

The 50-500 rupees price range for a strip of 10 makes me think it is unlikely they are really selling it for 50.

#2283

Ran into couple studies that suggest that statins help with telomere length, hence slow down aging. I have normal cholesterol, but would any of you guys think taking a statin might be a good idea for anti aging? Plus is anyone (with normal cholesterol levels) in these boards taking statins?

#2284

I had LDL in the low 110s prior to starting my rosuvastatin/ezetimibe combo. Now Iā€™m in the mid-50s. Other than some muscle-related sides that resolved upon starting ubiquinol and ā€œbrain fogā€ which resolved on its own, I had no major issues.
Keeping your apoB low is extremely important in us humans as itā€™s the biggest killer in the Western world. The off target effects of statins such as reduced inflammation, possible reduction in dementia rates etc. may also be beneficial for health.

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#2285

What is ā€œnormalā€? I think a lot of people here are shooting for ā€œoptimalā€ wherein LDL-C/apoB are low enough to preclude ASCVD. For me, my LDL-C ranges from about 58-70 mg/dl and I hope to reduce it into the 30-40 mg/dl range (apoB and LDL-C are pretty close in this range from my tests). Iā€™ll try the B+E combo to see how far that gets me, and then possibly add a statin later.

Also, could you post the telomere studies?

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#2286

wow thanks, this is totally new to me. I literally thought of statins as being big no no unless you are prescribed them by a doc. So that I understand this correctly (Iā€™m a bit new to this anti-aging thing) using statins helps lower ApoB right? I think i can live with side effects as I know couple people (one of them my uncle) who have been using statins (cholesterol issues) for last 25 years (now at 95) with no major adverse effects.

#2287

I literally thought of statins as being big no no unless you are prescribed them by a doc.

While it is generally a good idea to have a doctor monitor your blood markers when using a statin, research has shown that modern statins are very safe, particulary the water-soluble ones such as rosuvastatin. They significantly lower all cause mortality and the effect becomes larger the longer you use it.

Correct, it lowers apoB (and cRPC (marker of inflammation)).

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#2288

Pardon my ignorance what is B+E?

#2289

Bempadoic acid + ezetimibe, most commonly 180 mg bempadoic acid and 10 mg ezetimibe, which is based on clinical trial data. Brand name ā€œNexlizetā€ but widely available as a generic from India.

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#2290

It is all making sense now. My uncle was always sick (major heart problems, on top of high cholesterol) and no one expected him to live this long. And all he takes is just Statins (donā€™t know which one).

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#2291

Any reason why youā€™d prefer B+E as opposed to statins? Or supposedly fewer side effects?

#2292

@DeStrider how is ezetimibe working for you? What dose are you taking?
I am starting with 10 mg a day now, taking no statin, might add it later if I donā€™t find any other medicine like bempedoic acid.

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#2293

I wouldnā€™t expect an LDL reduction of more than 30-35% with the B+E combo.

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#2294

Were you also taking a PCSK9i?

What do you think the optimal adjunct thereby for someone on PCSK9i who is still not low enough vs aggressive Apo B targets? (In my case I also have genetically elevated Lp(a). I was thinking of adding ezetimibe.

#2295

Yes supposedly less muscle pain side effects commonly reported with statins. Then again, there are many others

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#2296

No but I am thinking about adding a PCSK9 inhibitor.
I would say ezetimibe + bempedoic acid, also a fibrate could be interesting as well

#2297

Ok, thanks. Happy with the PCS9i as my base med, including for what looks like a very good safety profile (and I experience no side effects) and because it helps lower my Lp(a)by around a third, but may research the fibrates in the future.

#2298

Bempedoic 1.3% -prostatomegaly reported vs 0.1% placebo. That is no joke. Too scary for me. Would have considered if it was maybe double the placebo, but not 10 times higher. Iā€™ll probably give Rosuvastatin at small doses a try and see how it goes.

#2299

Here are the changes I noted in my relevant blood markers after a few months of ezetimibe 10mg.

goal 7/5/23 10/16/23
APO B <70 87 77
LDL <70 98 83
HDL >60 60 67
Total Cholesterol <160 169 162
Triglycerides <70 48 57
Tg/HDL <1 .8 .85

The results showed positive effects and no side effects, but I havent reached my goals yet. Will continue with 10mg

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#2300

I accidentally pinged you when I meant @DeStrider always mix you two together since itā€™s both a purple C :rofl:

But yeah you both had negative effects from statins, interesting to hear youā€™re using ezetimibe as well.

#2301

I no longer believe Iā€™ve had negative side effects from statins.

I was confused by the muscle soreness and occasional strains I get from work outs. But it doesnt seem that my pains are what is described as a statin side effect, so Iā€™ve increased my minimum dose rosuvastatin from alternate days to daily in hopes for further lipid improvement. Doctor agreed.

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