Rapamycin and lean muscle

[Philly3458]

Can you build lean muscle while taking to Rapamycin? Is there a risk of sarcopenia when taking low dose Rapamycin long term?

[RapAdmin]

The evidence is pretty good that rapamycin prevents sarcopenia.

Here are some such studies that report this benefit:

• Rapamycin protects aging muscle (2019 Research Paper)
• Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice
• Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis
• Age-related muscle loss: Study finds rapamycin may delay sarcopenia; diet, exercise key to minimise decay

Also - I recommend you read these past threads on rapamycin and muscle:

• Rapamycin, mTORC1 and Exercise - Observations and Research

• Rapamycin and Exercise: Is There any Muscle Growth Inhibition?