#231

I have looked on twitter and youtube and there is nothing there.

1 Like
#232

The trial says $100k of $500k funded as well, where it has been stuck at.

#233

He sent out a short video to members of his Patreon channel.

3 Likes
#235

Thinking of investing in this - do you know works with any wrist strap or arm strap that are good?

#236

Answered on separate thread as well, Scosche Rhythm 24 is the only arm strap that works with Morpheus. I highly recommend this instead of the Morpheus chest strap.

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#237

See discussion here: Exercise, VO2 max, and longevity | Mike Joyner, M.D - #158 by Davin8r

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#238

I’d love everyone’s feedback on my tentative rapa + exercise schedule. I do concurrent training (strength + cardio) and typically run microcycles of 9-10 days, rather than planning exercise on a weekly schedule). I’m trying to decide where to best fit rapamycin.

It seems like it might be a good idea to do strength training first and then take rapamycin to avoid negatively impacting adaptations through mTOR inhibition. With this in mind, here’s my tentative plan:

9 to 10 day cycle:

  • Day 1. Lift: A (Lower body)
  • Day 2. Lift: B (Upper body)
  • Day 3. Easy (less freq.: Moderate or hard cardio); Rapa later in the day
  • Day 4. Easy cardio
  • Day 5. Easy cardio
  • Day 6. Lift: C (Lower body)
  • Day 7. Lift: D (Upper body)
  • Day 8. Hard cardio
  • Day 9. Easy cardio or rest
    …and repeat.

Notes:

  • I plan to take the standard dose, working up to 6mg once every 9-10 days, starting with 2mg, then 4mg, and finally 6mg.
  • I usually work out in the morning.
  • Easy cardio typically involves one hour of zone 1-2 activity.
  • The hard cardio day usually consists of HIIT (high-intensity interval training), for example, 3 sets of 5 minutes with 2.5 minutes rest.
  • Moderate cardio would be sweet spot training, but I’ve been opting for the polarized approach lately (just easy + hard; no moderate)
  • I try to avoid taking rapamycin before lifting and before HIIT, as HIIT is quite challenging and I really don’t want to blunt adaptations, that’d be a bummer to go through this pain for no gain :). But if there’s no risk of blunting HIIT adaptations, as it’s a form of cardio, perhaps I could try: lift, lift, easy, lift, lift, HIIT (with rapamycin later in the day), easy (or rapamycin later this day), easy, easy."
3 Likes
#240

Can you share a bit more about your overall objectives for the exercise program, and perhaps a general age range? For example, are you seeking to improve VO2 max, increase strength and muscle, or maybe just to maintain your current fitness level?

(Reposting as a reply)

#241

Objectives: all of the above, but with more emphasis on cardiovascular improvements these days (VO2 max, stroke volume, capillarization, mitochondrial function, etc). I’m fine with maintaining or gaining slowly in terms of hypertrophy/strength, hence only ~3 days a week of lifting on average (4 / 9.5). Does anything stand out to you in terms of potential improvements?

#242

One improvement would be to plan one day of a longer zone 1-2 cardio, 1,5 to 2h in you schedule

#243

Yeah, one I thing I haven’t noted is that I have this rule: “if it’s (1) a weekend, (2) an ‘easy’ day, and (3) I have time, do a long session, e.g. 2 hours”

#244

I like the 24 hr break between the last lift and before rapamycin, and then the long break before the next lift. If I were just interested in maintaining I might do something very similar.

1 Like
#246

Would you be open to sharing what you do instead? Thanks!

#247

Can 100% say that rapamycin 1mg/wk does not inhibit muscle protein synthesis for a 21 year old, gaining muscle like I was 16/17.

2 Likes
#248

Sure thing. I’m currently doing a hypertrophy focused program to put on muscle mass, so I’m out of sync with some of this forum. 4x a week, 1.5-1.45 hrs a session, ~25 sets per major muscle group per week. Lower or upper emphasis but with accessory exercises to hit most muscle groups each session. Blocks are 4 weeks long.

Screenshot_20240406-095139
Screenshot_20240406-0951391440×939 134 KB

Zone 2 cardio, alternating slow jog on the treadmill with bike trainer, 2x/wk, 1 hr. Norwegian 4x4 on the treadmill 1x/wk. Concerned about rapa inhibiting muscle protein synthesis, but I want some benefits, so my most recent thinking is this:

Sunday: 3mg rapa am, maybe with 5mg MOTS-C. Zone 2 cardio afternoon, GlyNACET. I intend on getting labs done to check levels and will adjust from there.

Monday am: Z2, GlyNACET

Tues eve: ~1 half life of rapa has elapsed, Upper body emphasis lift.

Wed am: Lower body emphasis

Thurs: am 4x4, GlyNACET

Fri am: Upper emphasis

Sat am: lower emphasis

Sometimes Thursday is too busy. If so, take Thursday off, do 4x4 Sat morning, Lower lift later in the day… but I’d prefer to finish the lift about 24hrs before I take rapa so this isn’t ideal.

Then at the end of each 4 wk training block, instead of 3mg rapa, a large dose during a maintenance week. Will have to experiment and think about the half life as I head into the next block. More labs.

Before this program I was doing 3x a week total body with a classic powerlifting compound lift emphasis, strength focused. Heavy weights, low reps, shorter sessions, 48 or 72 hrs between workouts, cardio on the other days. The heavy weights cause a lot of wear and tear so the current program is kind of a break even though the volume is much higher.

3 Likes
#249

Makes sense, thanks!

Are you not concerned about NAC’s potential to inhibit exercise adaptation through its antioxidant properties? And potentially interfere with Rapamycin too?

I’ve read an argument that NAC blocks hormesis caused by other supplements because of this. These studies were quoted:

#250

I’m concerned about the former, so I’m only taking a small amount of the GlyNACET as far from lifting sessions as I can manage because my serum glutathione is really low. I’m probably trying to do too many conflicting things at once, and need to have a more consistent strategy, but my hope is that I can raise glutathione and use the small bit of rapa to counter inflammation to some extent while still packing on as much muscle as I can for 6 months.

1 Like
#251

What App are you using (that the image is from above) to track your exercise routine? do you recommend it? I’m still looking for a good app for tracking this sort of thing.

#252

@RapAdmin, that is from Juggernaut AI, which uses an algorithm to plan and dynamically change a resistance training program (even set-to-set while you lift). I did a test drive of it for 2 weeks and decided it was worth the monthly cost for a few months… pending results.

The other one I was considering is the RP Hypertrophy app, but I admit Juggernaut AI pulled me in with the slick interface. I’ll prob try the RP app in 6 months.

Neither is truly necessary, but not having to do my own programming saves time and I also don’t have to think mid-session about whether I should adjust based on how well I did on the last set. And the tracking is very nice for those of us who like metrics.

Edit: for calorie and time tracking, I just use Polar Flow since I always wear an H10 monitor while training.

3 Likes
#253

Quoting myself to follow up after about 5.5 months. It’s clear that 4 mg/wk rapamycin doesn’t impact strength and muscle gain for me. I landed on a 44-48 hr break from resistance training after a rapa dose, then 5 days in a row of 60-90 min weightlifting sessions. I switched from Juggernaut AI programming to a Stronger by Science hypertrophy program after 12 weeks.

My strength levels are “intermediate” by online strength standards, but I’m now farther along in the bracket. I’ve been able to progressively increase volume and strength. My fear was that rapamycin wouldn’t interfere with beginner or novice progression, but would interfere with intermediate or advanced lifters. This has not been the case.

I’ve gained 15 lbs by eating in a surplus, 3300-3700 calories a day, since mid March. Using DEXA scans with measurements and photos in-between DEXAs, I think most of it is lean mass.

I’m comfortable enough at this point to increase my rapamycin dose to 5mg for a few weeks.

A contributing factor is probably that I’m on TRT that puts me in the upper normal range, but not in a supraphysiological, baby-steroid-cycle “TRT+” range.

5 Likes