Another question for Matt:
How low is “low” blood sirolimus levels before the next dose of weekly rapamycin? What should we target for the trough levels of blood sirolimus testing?
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probably better dosing regimen to induce compliance
ginnyw
#47
I did:) I don’t let age stop me in any regard. I have muscle pain, misalignment, fatigue, etc. but nothing I would blame on Rapa. Been on only about 4 months, at 5mg weekly. No symptoms or reactions whatsoever. Female, way post-menopausal, active, keto/IF.
ginny
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Possible Question:
What studies have there been as to the effect of rapamycin on cell division relating to stem cells more generally. There is evidence that Rapamycin reduces nail growth. It is known to hold back cell division as that is the mechanism that gives it the ability to prevent rejection of kidney transplants. Hence it should have a point at which it is reducing stem cell production. What studies are there on that and what does it indicate for dosing both frequency and amount?
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Interesting regarding the nail growth. You mentioned there exist evidence that Rapamycin reduces nail growth, do you have a study supporting this. Curious to read this.
This is aligned with anecdotal report from Peter Attia. Here is a time clip where he mentions it.
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I started a topic on it yesterday
I was wondering what was the factor that caused some people’s biomarkers to go backwards at a higher level of rapamycin. I think this is probably it although obviously immune issues can be as well.
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Beth
#51
For Matt:
Should we keep weight in mind when figuring out our individual doses?
I realize no one knows at this point, but perhaps you can assist us with putting together a rough guide, with the caveat that it’s experimental?
It’s been suggested that 6mg is a good target dose, and it’s what my doctor prescribed.
Where did this 6mg suggestion come from?
Can I assume this is for the average sized person, and if so, what does this average person weigh?
If we take one’s weight into the equation, how many milligrams might we consider adding or subtracting for each, let’s say, 10-20 pound-ish difference?
I realize the dosage for many medicines and vaccines are not weight dependent, so how we know when, or even if, we should be thinking this way?
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Another 2 part question:
Is there any evidence of tachyphylaxis and/or tolerance to rapamycin over time?
And if so, would varying the dosage and/or frequency mitigate this from occurring?
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@Dr.Bart Very good question. After almost 2 years on Rapamycin, it doesn’t affect me the same ways it used to. I’m not sure if that’s a good or bad thing. For instance, much fewer side effects both good and bad.
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I find it odd that I’m constantly cutting my fingernails while I’m on rapamycin. And, my hair grows like weeds, I’m getting haircuts every 2 weeks and I’m cutting my nails at the same time. This was not typical pre.rapamycin, so that’s my N=1.
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Neo
#55
Think you boost some growth pathways - eg high testosterone? That might be part of the story here?
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Definitely could be… need to add my nails are very thick… and healthy too. Look amazing.
Very different from my before Rapamycin dosing… and even since getting over toe fungus 1 year ago. Toe nails look fantastic. Like a much younger guy.
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Nail growth requires stem cells. Hair growth is only protein.
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Well I do max out on protein. Large quantities most days.
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Stem cell creation needs a lot of protein as well. The main point is that if you have adequate nail growth then Rapamycin is probably not doing that much harm to stem cell production (or indeed the immune system). I have no idea where the balance lies in terms of the creation of lymphocytes vs other new cells, but we should expect rapamycin to affect a range of cell creation (including RBCs).
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I wonder if rate of nail growth can be a metric for health or some element of health. From anecdotal evidence shared on this site it appears that rapamycin adjusts the immune system in some way that restores a more youthful tolerance of allergens.
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Nail Growth is a good sign of stem cell production. Hence it would reflect a wide range of health issues.
There is also a question about the quality of nails.
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Neo
#62
Do other things like vascular circulation, the environment’s temperature, other hormones, diet, etc affect nail growth at magnitudes that make it touchy to use as barometer of stem cell function - on less changes are done “with all else equal/similar”?
More importantly, do we know if we actually want to have stem cell activity generally revved up… Seems to me that we for a longevity goal perspective may want stem cell activity relatively revved down most of the time, with the capacity to rev up quickly and forcefully occasionally when actually needed?
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Although obviously there will be factors that affect stem cell production and quality of nail growth other than aging, we do wish to maintain the renewal systems of the body.
Neo
#64
Yes, but maintaining the system is not the same as having the system revved up on an ongoing basis.
