#109

The comprehensive magnesium guide from a Doc you can trust.

I like magnesium glycinate.

If you’re constipated, go with magnesium citrate.

2 Likes
#110

I only lurk on it so if anyone is interested in what Karl think is optimal levels.

It would be interesting if someone compiled a list of what all the longevity people think are optimal levels of vitamin D (for another thread)

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#111

I went a bit OTT on the calcifediol at one stage and hit 419 nmol/L (over 160 ng/mL). It dropped back pretty quickly, however. I think it tends to be cleared in the form of 24,25 di Hidroxy Vitamin D when there is a lot around.

I normally aim for around 200 nmol/L. (thats about 80 ng/mL) However, I have been experimenting with various constant supplementation rates and it has been dropping down (even on 6,000 iu per day). I have switched to 25OHD at the moment and am waiting for some test results to see what is happening.

I switch the supplementing amount on the day after the blood draw, but I want to run with a specific amount for a few weeks.

#112

TY! I just watched and this was EXCELLENT! Very clear and concise!

So, it seems I can skip magnesi-om because I don’t have the issue citrate addresses.

Mag glycinate does sound like the right one for me. Do you happen to know if I still would take additional glycine or it’s instead of?

Additionally, it seems that L-threonate might also benefit my ADD brain.

And he mentioned something about gallbladder and choline (or ox bile). I don’t have a gallbladder, so now to do the deep dive to see if I should be adding a choline supplement or sunflower lecithin (a source of choline) … it’s endless!!!

#113

The mortality curve says you should have a vitamin D level above 40. Some people say 50-100 is even better. But no reason to go over 100.

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#114

This thread might be helpful

And @约瑟夫_拉维尔 podcast on the topic

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#115

Neo! This was great! Ok, I’m back on citrate :). THX @John_Hemming for explaining it’s good for bones and not just to help w regularity.

I’ll go listen to that podcast now. I thought @约瑟夫_拉维尔 summary of it was good….

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#116

Because citrate is a substance found a lot in the body and is normally in blood to a certain level you need quite a bit to move the needle.

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#117

Curious, what do you you disagree on in Matt Kaeberlein’s ranking video?

#118

It was an interesting video. I am a bit busy at the moment, but I think it would be good for someone to summarise the list of interventions and his categories and to discuss this.

#119

Cancer screening and Rapamycin definitely ranked too low.
Dexa, CGM too high

1 Like
#120

What letters would you rank them?

#121

I have gone through and tried to list out the video rankings. There are quite a few I would disagree with and for someone over 40 Rapamycin logically would be an A even in infrequently rather than a C.

A HRT, Flossing/Dental care, Blood Testing, D3, DNA Testing, Resistance Exercise, good sleep, Cardiac exercise, Not smoking, Not drinking a lot, Hormone Replacement Therapy
B RIR?, MultiCancer early detection testing, Creatine, CGM, Cognitive Function Test
C Wearables, Rapamycin, Crosstraining
D Bioimpedance Scale, Methylation/Epigenetic Age tests, NMM, Time Restricted Feeding, Microbiome analysis
F Resveratrol, Skin aging clock

I have done this from a glance at a still of the video combined with my vague memory of seeing the video a few days ago.

This is the list of chapters in the video

0:00 Trailer 0:49 Introduction 2:07 Regular dental visits/oral care 3:31 DEXA scans 4:43 Bioimpedance scale 5:16 Fitness wearable 5:45 Bloodwork 5:59 Multi-cancer early detection testing 7:07 Epigenetic age testing 8:03 Nicotinamide mononucleotide (NMN) 9:56 Resveratrol 11:19 Rapamycin 12:55 Vitamin D3 14:53 Genetic testing, e.g. 23andMe 16:20 Sleep 16:46 Intermittent fasting/time-restricted eating 24:42 Exercise (cardio + resistance training) 26:52 Cross-training 28:00 Creatine monohydrate 28:48 Not smoking 30:33 Not drinking 33:12 Continuous glucose monitors 33:40 Microbiome analysis 38:15 Hormone replacement therapy 45:34 Skin aging clock 46:24 Cognitive function tests 50:58 Wrapping up

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#122

Cancer detection clearly an A.

Dexa and CGM don’t really fit into his categories. Do they work? Absolutely. But do you need them? I question that.

I think the problem is the Matt K. Has made the same mistake as others in that he has decided that since he’s an expert in one area, he considers himself an expert in a much wider area.

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#123

He shared his opinion. Do you have to be an expert to have an opinion? Are you an expert in opinions?

#124

I tend to agree but I personally find it useful to know what a smart well educated well connected person thinks about these things on which I struggle to separate marketing from science. I think he is hurting his credibility but I hope he continues to do it.

#125

I find it is useful that he gives a broader perspective. People who are experts in a narrowly defined subject tend to think that their area of expertise is perhaps more important than would be thought be experts more generally.

#126

One other key question to him is: What are your thoughts on how rapa can be combined with things that offsets the risk of decrease in mTORC2? Eg acarbose, fasting, 16-alpha, other?

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#127

I disagree on Vitamin D. By their criteria it cannot be higher than a B. Now I believe it will eventually be an A , but the data doesn’t support this currently.

I spent 10+ hrs researching the blog and writing this … so I’m pretty confident on that item.

Tend to agree w @KarlT with other stuff

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#128

I am an expert on my opinion lol. He’s an expert on his opinion. But since he’s on YouTube he is essentially selling his opinion and we get to critique it. I am finding that the wider he goes the less impressed I am.

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