#1

Trying to follow the 9 and 16 months old mice on rapa plus acarbose protocol, one would dose daily, correct? Is it indeed so that, for example, the side effects of 7 mg weekly are that much more tolerable than 1 mg per day, so much so that such an otherwise unnecessary deviation (from what has been shown to have the desired effect in our mamal cousins) is justified?

#2

Hi, you can’t really directly compare the dose used in the mouse studies directly with human dosing. Mice process the rapamycin much faster than humans; the half-life of rapamycin in mice is about 15 hours, vs. about 65 to 70 hours for humans. So daily dosing for mice is almost like weekly dosing for humans.

I recommend you review these threads on dosing strategies. The dose of once per week seems to provide for most people a good balance of efficacy and low side effects; but some people are modifying that strategy a bit given their own results. We are all just working to find out what works best for our bodies.

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#3

15 versus 70 h (if so, and not the 8 h often mentioned instead) is a valid point. Thank you.

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