#41

I don’t think that one IP6 is better than the other. I just get the cheapest I can find. Vitacost, Swanson etc.

#42

I wanted to be clear of rapa in my blood and think that is at least 7-9 days
10 is about the max I can take without side effects

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#43

FWIW

Rapamycin is also approved for cancer treatment by the FDA.

With that stated, in my view FDA approved means nothing.

Review published literature and make your decision.

"When writing the story of your life, do not let anyone else hold the pen.”

~Jack Kerouac

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#44

Life can change in a flash.

Two days ago I wouldn’t have paid much attention to this thread. But Friday, during a visit to a urologist with BPH issues, a digital returned “nodule on the R side.” Three hours later I was looking at a PSA of 54. (Note: Above 4 is a cause for concern.

I haven’t been diagnosed yet but from that 54 PSA the real question now has the CA gone metastatic.

A beginning of a journey that about 300,000 other men traverse every year.

Thanks all for the responses, there’s plenty to read there.

Btw, I think I know “how I got it.” 1972, I spent a summer spraying herbicide under power lines. The herbicide was 3-4-5T aka “agent orange.”

Interestingly, yesterday I took my first full 6mg of Siralimus having gone from 1mg>6mg. I’m thinking of cutting back to 2mg w/ GFJ and doing a max blood test + one at 24hr and one at 72 to find my metabolizing rate and then up to 3mg w/ GFJ and so on.

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#45
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#46

17ae2 could be worth trying

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#47

@Justin Any follow up on your situation?

#48

Because I started this topic, I wanted to offer a follow-up. This is not useful, but it’s closure.

My friend died in March. He did not die from prostate cancer, but with it. He used to tell me how that was more likely in his demographic, and was in a sense the situational win. Though he wanted another ten years, at least. But that’s neither here nor there.

I suggested rapamycin to him, but he never ended up trying it. He was using some other alternative and mainstream treatments – I am fairly confident that it was the radiation that tipped him over into decline. I’m not going to say much about the alt treatments because I don’t want to imply anything about how well they worked or didn’t.

While this update is irrelevant to this discussion, I wanted to offer closure.

Carry on.

PS: he was fairly well known as a citizen researcher in other biohacking circles. If you want to read the post I made to phoenixrising.me about him, please contact me directly.

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#49

Thanks for asking KarlT. I have a T2b/0/0 tumor with extra-prostatic extensions into adjacent structures but with a current depth of <10mm. Using the Yale formula which looks at numerous tumor factors the likelihood of distant metastes exceeds 100%, yet there are no distant metastases, according to a PSMA-pet scan (~80% sensitive), a very + thing.

I’ve been to many “radocs” (radiation docs) and one very good medical oncologists. It is fascinating, you may have a hankering for tenderloin, but if the butcher is out of beef, he’ll wax poetic about the flavor of his chicken—and that’s largely what I experienced.

Prostate Cancer (PCa) is largely sequestered into groups based upon Gleason Scores, PSA values, tumor size and whatnot, and treatment is really very “cookbook’ish.”

Therefore, what I got from all was: Lupron for 2-3 years + IMT radiation therapy (8 weeks) + a bit of prayer. My prayer itinerary, from a distant past (Boy Scouts) was, “rub a dub, bud, thanks for the grup, yay God.”

What I intend is Orgovyx + Abiraterone + 5 weeks of IMRT radiation + 1 week of radiation to pelvic lymph nodes (in case there are micro-metases.) Then, I will got to Dana Farber in Boston and get what is known as brachytherapy, where they place rice-sized radioactive “seeds” in the prostate. I hope to be done w/ the Orgo + Abi at the end of one year—the Androgen Deprivation Drugs are brutal, but one year is doable. On the other hand, I’ll do a Decipher genome test which allocates a number from 0.01>0.99, higher = more aggressive. If high, I’d likely stay on those terrible meds longer.

This combination appears to give me an 80% chance of ten-year survival. More importantly, over the standard therapy, the graphs using brachytherapy “goes flat,” which means a good likelyhood of a 12-15 year survival. I had hoped to live to age 95, based upon my genetic family past.

Why Orgovyx? Lupron, the “old” standard, if I had been on for 2-years would take about 2-years for my Testosterone to bounce back (and it may never bounce back at all). Orgovyx allows one’s T to bounce back in a couple of months. Further Orgovyx has a much better cardio profile.

The Orgovyx cost, retail = $2,950 a month. I’m told that I should be happy because I only pay $850/month on Medicare Advantage. But, as I do with my Sirolimus, I am buying 4 months to be shipped from India, to arrive near the end of the month.

Interestingly, next year the “cap” (currently $7500/year) on meds w/in my insurance drops to $2,000, so starting January, I won’t need to get them from India.

In the meantime, hoping to prevent any distant metastases I’ve been taking Sirolimus + 1200mg ALA + 1 gram NAC + Curcumin (1.5g 95%) + Ubiquinol 200mg + Celecoxib + Rosuvastation + Metformin, each which has anti-proliferative and anti-angiogenesis effects. There is no “cure,” there but there may well be the creation of a micro-environment that makes a micrometastatic tumor unable to grow or create it’s necessary blood supply.

In addition, over the past year I’d water fasted 44 days (1,2,3 and a few 4-day fasts) and have been in +1 or more ketosis for more than 80% of days, all of which may have been the reason that the Yale formula predicted distant metastases yet I appear to have none.

It’s a fascinating, but tiring journey.

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#50

I would be interested in finding out what citrate does in this situation. It is clearly a splicing issue.

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#51

Me too, citrate is fascinating. Alas, one substance at a time…

#52

Some papers indicate the normal dietary quantity of citrate is around 4g per day although this will vary.

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#53

What is the best form of citrate? or most absorbable?

#54

There is a topic on this

#55

I searched on topics but couldn’t find anything about the best type of citrate?

#56

This is where @John_Hemming talks about his protocol.

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#57

Prostate enlargement and cancer are the clearest examples of the hyperfunctional theorem of aging. When you are young, it is the size of a walnut, but after 65, if you have not taken any supplements or precautions, it becomes almost the size of a tangerine or even an orange, and eventually these extremely hypertrophic cells become cancerous. Therefore, in the 40s, rapamycin prevents this outcome by preventing all the ways I have described. The patient has nothing to lose, rapamycin is also an immunomodulator when given in low and intermittent doses. It may be beneficial to try intermittent and low-dose rapamycin.

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#58

Alternatively prostate cancer is a fine example of aberrant splicing.

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#59

The strategy kept the company going in the runup to a December readout of positive phase 3 results for its lead viral immunotherapy candidate CAN-2409 in prostate cancer, reaching the primary endpoint of disease-free survival. The prospective drug is an off-the-shelf virus that delivers a type of herpes simplex gene to induce an immune response along with radiation therapy.

Because Candel had a special protocol assessment agreement with the FDA, the prostate trial could serve as registrational for regulatory approval, and Tak said the company is aiming for a fourth-quarter submission to the agency. The biotech is also using similar therapeutic approaches for earlier-stage candidates in diseases like non-small cell lung cancer, pancreatic cancer and high-grade glioma.

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#60

Prostate enlargement (benign) and prostate CA are separate entities. Enlargement does not predict an increased cancer risk. Anecdotally, I see far more patients with small prostates and bad cancer as compared to massive prostates with bad cancer. Rare to do a RARP on a patient with a >100g gland. Very common to do a HOLEP for benign BPH in this demographic. Furthermore, enlargement (BPH) happens in the transitional zone whereas 70% of cancers occur in the peripheral zone. We do see transitional zone cancers, but they are less common and again I don’t see a predilection toward those with larger prostates.

I do agree BPH is essentially hyper function. Tend to see larger prostates in men with obesity, insulin resistance, metabolic syndrome. Some interesting data that the pre-prostatic fat pad can secrete cytokines in a paracrine fashion that will induce anterior tumor formation in this same metabolically deranged group.

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