#41

https://www.nature.com/articles/s41419-023-06080-9
Interesting paper on statin intolerance. They find a connection to cannabinoid receptors, and that cannabis is not a solution (my interpretation).

1 Like
#42

I believe the source paper for Bill Faloon’s article, can be found below:

Click

[

There is urgent need to treat atherosclerotic cardiovascular disease risk earlier, more intensively, and with greater precision: A review of current practice and recommendations for improved effectiveness

](https://www.sciencedirect.com/science/article/pii/S2666667722000551)

Michael E. Makover, Michael D. Shapiro, Peter P. Toth

Then click “view pdf”.

1 Like
#43

Declaration of Competing Interest

Michael Makover: None. Michael Shapiro: Dr Shapiro has participated in the Scientific Advisory Boards for Amgen, Esperion, Novartis, and Novo Nordisk.
Peter P. Toth: Dr. Toth is a member of the speakers bureau for Amarin, Amgen, Esperion, and Novo-Nordisk; he is a consultant to Amarin, Kowa, Merck, Novartis, and Resverlogix.

#44

Doesn’t matter, only the methodology does.

#45

I just got my prescription for 10 mg daily Ezetimibe. Took the first dose last night. I had a hard time sleeping, but I don’t think it was the Ezetimibe (hopefully). No muscle soreness. Looks like we have a winner.

Unfortunately, it’ll only lower LDL cholesterol by 10-20%. Probably nearer to 10%. However, I’ll take it.

Next trial will be Bempedoic Acid.

2 Likes
#46

Have you already tried very low doses of rosuvastatin like 2.5mg or even 1.25mg daily? In combination with ezetimibe even that should give you LDL reductions of nearly 40%.

1 Like
#47

I’d have to split the pills, and honestly it took me weeks to recover from those statins.

I may try a different statin in the future, bit for now, I am staying away from Rosuvastatin.

#48

It is Ezetimibe! I also have hard time sleeping after I take it. Started taking it in the morning - it helps.

1 Like
#49

Really?!?! The higher energy is a bonus then.

1 Like