AnUser
#162
A1C between 7-7.9% is healthiest then. I don’t believe it. Seems like another fake U-shape curve.
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Josh
#163
Maybe a bunch of the people below that had diabetes and are on lowering medication?
Neo
#164
A lot of people with AD end up missing a lot of meals and being malnourished and low HbA1c?
Or are you saying you think 7 is actually better than 4.5-5 or even than 6?
1 Like
adssx
#165
No I’m not saying anything. My guess is that the group below 6 is including a lot of people with hypoglycemia who have a low HbA1c but a terrible glucose time in range. I’m not sure HbA1c is a good metric. The best might be glucose time in range (how much time in 4-6.7 mmol/L?), but you need a CGM for that.
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Study examines effect of fish oil in older adults’ brains
Clinical trial finds statistically significant benefit for those genetically predisposed to Alzheimer’s
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Omega-3 fish oil is a No-brainer IMHO. The majority of Americans are deficient. Everyone in my family takes it.
I take the NOW Ultra Omega-3 2g daily. I have never had a problem with it going bad. BUT…
Remember to keep it refrigerated if possible to prevent it going rancid.
It also reduces the chances of developing psychosis, so it makes sense that it would also help with AD.
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Vitamin K may prevent (i.e. reduce risk of) cognitive decline
A new study from AlMaarefa University in Saudi Arabia indicates that vitamin K may help protect against “cognitive deterioration.” The new study, which was presented at the Experimental Biology meeting on April 5th, 2022, tested giving a vitamin K supplement to rats.
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Neo
#169
I take it too. Do think it’s very important to not have it go rancid + to really go with a good brand and even then check your blood work for mercury / heavy metals.
And measure omega 3 index to not overdo it as their are some risks of A fib
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AnUser
#170
Is the risk of afib based on omega-3 index?
Neo
#171
@AnUser I meant that the index can help you know your levels so you are not overshooting and taking too much / more omega 3 that needed
AnUser
#172
We know afib risk based on dosage, not omega-3 index, afaik?
Based on my research, 4 g daily is a risk of aFib. 1 g is not a risk. 
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Thomas Dayspring has this to say:
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@AnUser right again … BUT the total picture here is that the studies didn’t look at Omega 3 index, they looked at total dose, which, just like the vitamin D story is really problematic.
We believe that best heath outcomes in this area relate to an Omega 3 index of 8-12%.
Most people will achieve an 8% with about 1 gram of EPA/DHA which was the threshold for starting to see increased risk of AF.
My usual strategy is to go with minimal dose that gets someone to 8% to minimize risk and maximize benefit.
@DeStrider I’d be reluctant to be on 2 grams of DHA+EPA unless I’d measured and was inadequate on Omega 3 index. If needing over 1 gram per day, I’d also look at decreasing Omega 6 fatty acid sources to encourage more conversion of plant based Omega 3’s to DHA/EPA. The folks going with high dose Omega 3’s have a lack of evidence for doing this, and perhaps if they are super healthy otherwise, the AF risk isn’t applicable to them … but on a risk benefit, I’d say this has a sweet spot just like Vitamin D … need to measure and dose to targets.
The OmegaQuant mid range test seems good, but is $75, I’ve been going with one through Access which sends to Cleveland Clinic, and gives a report similar to the $100 Omega Quant for $69. Anyone have better deals on this - is just an expensive test.
4 Likes
hitch
#176
Marek Health has the “OmegaCheck” for $60 (+$5 labcorp fee)
It tests: EPA, DPA, DHA, Omega-3, Total Omega-6, Total Omega-6/Omega-3 Ratio, Arachidonic Acid, Arachidonic Acid/EPA Ratio, Linoleic Acid
OmegaCheck™ , a specialized blood test designed at Cleveland HeartLab, assesses relative cardiovascular risk based on polyunsaturated fatty acid (PUFA) status. Additional tests are included to determine levels of specific Omega-3/6 fatty acids. This panel can guide nutritional intervention to support optimal omega balance and reduce cardiovascular disease risk.
OmegaCheck™ measures the amount of fatty acids in red blood cells, while most other omega-3 tests look at fatty acid levels in plasma. This provides a more accurate representation of omega-3/6 fatty acids levels over the last 2-3 months and is not skewed by recent omega-3/6 intake.
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@DrFraser Thank you for your advice. You are correct that I should measure my Omega 3 levels before I go above 1 g of Omega-3 fish oil. I’ll reduce to 1 g and then test to see if that’s adequate.
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Yes that’s the same one I order through Access Labs … the other thing is that is takes 4 weeks for turn around - but it is a detailed report.
1 Like
Neo
#179
Are you actually not understanding what I am trying to say?
If so I can invest in trying a third time
AnUser
#180
The risk of Afib from Omega-3 is not measured via Omega-3 index.
Neo
#181
Yes, but, @AnUser , I have never said that
All that I had been trying to say is that people are taking Omega 3 supplements because they want to achieve some form of level
Rather than just guessing how many grams we should take, we can measure and see how we as individuals (and in context of other diet) respond to the amount of Omega 3 we supplement with
Someone who sees that they have a super low index may want to supplement a bit more
Someone with a very high index might want to supplement less
A person in that second group would likely be decreasing downsides from rancid fat, oxidative stress, risks of contamination/heavy metals and a fib without getting less omega 3 benefits as they were taking too much omega 3
Is like we measure cholesterol, vitamin D and then react based on the data
That is all I am saying - get the data and then include that in one’s decision making of what dose to continue forward with
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