A drug with no toxicity that might prevent and treat dementia in ApoE4 carriers. Very interesting indeed.
7 Likes
RapAdmin
#276
Recommended viewing by Dr. DaySpring:
Revolutionizing Brain Health: Genetics, Lipid Science, and Cutting-Edge Dementia Prevention
4 Likes
ng0rge
#277
Yes, an excellent presentation on The Proof podcast. I knew about the ApoE connection to dementia but this illuminated how this apolipoprotein ties in with ApoB and ApoA1 and also the relationship between brain cholesterol and peripheral cholesterol. Tom Dayspring was at his best and it was a lively discussion. Fascinating subject.
2 Likes
Association of Adherence to a MIND-Style Diet With the Risk of Cognitive Impairment and Decline in the REGARDS Cohort
Greater MIND diet adherence was associated with decreased risk of cognitive impairment in female participants.
Paywalled Paper:
https://www.neurology.org/doi/10.1212/WNL.0000000000209817
3 Likes
Neo
#280
Typically, individuals with early-stage Alzheimer’s disease perform progressively worse on standard neuropsychological tests, losing a few points every year. But in Chan’s study, participants’ test scores have remained stable. Brain volumes have shown no signs of shrinking and levels of a disease-associated protein in the blood have even trended downwards. “These patients have conquered the test of time,” says Chan, who presented the findings at an international conference on neurodegenerative diseases
https://www.nature.com/articles/d41586-024-03147-1
More discussion on the topic:
6 Likes
Neo
#288
7 Likes
ng0rge
#289
This certainly makes sense.
How Prioritizing Heart Health Could Lower Your Dementia Risk Later In Life
https://www.healthline.com/health-news/heart-health-dementia-prevention
“There are striking similarities in the inflammatory responses observed in patients with heart conditions and those experiencing cognitive decline. This suggests that damage to one organ, like the heart, may trigger an immune response that affects another, such as the brain,” Testai said.
Testai noted evidence of other mechanisms involved. The blood biomarker beta-amyloid, which is associated with Alzheimer’s disease, has been detected in cardiac tissue, where it is associated with cardiac dysfunction. The presence of beta-amyloid in both the heart and brain suggest a deep connection between the two systems.
5 Likes
adssx
#290
Buntanetap is a drug under investigation for AD and PD. It inhibits the production of neurotoxic proteins and has been shown to improve cognition in early AD patients (NCT05686044) and halt cognitive decline in PD patients (NCT05357989). Interestingly, last month, the company behind it filed three patents for combination therapies with dulaglutide and sildenafil @DrFraser!
Recent preclinical studies have demonstrated that when buntanetap is combined with a GLP-1 agonist (such as Trulicity) or PDE5 inhibitors (such as Viagra), cognitive function in Alzheimer’s mouse models improves to levels beyond those observed in healthy controls. With these compelling results demonstrating strong potential for cognition-enhancing combinations, Annovis further strengthens its intellectual property portfolio through the filing of the following patents:
- Buntanetap + Trulicity (dulaglutide, a GLP-1 agonist).
- Buntanetap + Viagra (sildenafil, a PDE5 inhibitor).
- Buntanetap + Trulicity + Viagra.
“Our early data suggests a strong synergistic effect from combining these drugs, resulting in significant cognitive enhancement,” said Maria Maccecchini, Ph.D., Founder, President, and CEO of Annovis Bio. “The combination of buntanetap with Trulicity and Viagra not only has the potential to restore cognition to healthy levels, but also to improve it beyond normal, offering new hope in the fight against dementia. Since buntanetap has completed Phase 3 studies as a standalone treatment, and both Trulicity and Viagra are FDA-approved, these combinations are well-positioned for Phase 3 human trials.”
We don’t have the preclinical data (and it’s in mice…) but it’s noteworthy that they chose dulaglutide (instead of exenatide, liraglutide, lixisenatide or semaglutide) and sildenafil (instead of tadalafil).
That being said, their stock is down 51% YTD so it might just be a desperate move to attract attention…
2 Likes
Tramadol use and incident dementia in older adults with musculoskeletal pain: a population-based retrospective cohort study
This study found that exposure to tramadol was associated with an increased risk of dementia.
Nature Scientific Reports - Recommended by Dr. Woody Merrel
1 Like
adssx
#292
3 Likes
Neo
#293
@adssx Might depend on one’s gender…
Where while:
For men:
4 Likes
adssx
#294
Check the charts though: Intermittent (oral) Rybelsus / Semaglutide use in healthy individuals? - #412 by adssx
Semaglutide appears to be protective after just a few weeks. So it’s most likely confounding BS. Unfortunately.
3 Likes
