#265

There seende to a theory that risk correlated with the amount of plack, so if done early/preventatively the risks would be (much) smaller

Seen it multiple times, but not sure if the data actually shows any such correlation as the trials with early stage use have not reported out at all yet?

#266

If that’s the case then I assume drug manufacturers have data on this and will try to convince governments and insurers. So far it hasn’t worked very well:

  • Aducanumab was withdrawn from the market (officially a commercial decision unrelated to safety or efficacy)
  • Lecanemab was approved in the US but I don’t know if insurers reimburse it. Same in the UK: approved but the NHS doesn’t prescribe it due to its cost + safety concerns. The EU didn’t even approve it. Approved in Japan though.
  • Rumors say that donanemab won’t be approved either by the UK and the EU. About to be approved in Japan.
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#267

This systematic review with meta-analysis finds that low-frequency, short-duration high-intensity training interventions are likely to improve or at least delay the decline in global cognition in older adults with cognitive impairment or dementia.

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Open Access Paper:

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#268
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#269

Based on this, I increased my omega 3 intake to 1.2g a day. Since I already take moderate doses of tmg, choline and b vitamins, this combination should hopefully protect my brain function.

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#270

Good news for acarbose and AD (in mice though…): Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer’s disease 2024

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Acarbose with food extends mice lifespan, does Acarbose "without" food also extend mice lifespan?
#271

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#272
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#273

Interesting

The novel solution provides accurately simulated flavour samples (known as virtual flavour, developed in collaboration with New Food Innovation) via an easy-to-use low-cost dispenser, which could be used by a nurse as part of an annual health check, in pharmacies, care homes, community centres and even in the home.

While in the trial stages at the moment, academics hope that one day an inclusive mobile Alzheimer’s screening unit could reduce significant pressures on the NHS and ease waiting times for those who are struggling to get an appointment with their GPs.

Professor Alan Chalmers from WMG at the University of Warwick said, “In this simple screening test, people will be given different flavours to smell and taste – they then determine which is sweeter, less astringent, smells more of lemon, for example. It’s an easy, non-invasive test which can be rolled out to people quickly across the UK.

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#274

Along the same lines this was a fascinating story about the discovery of a smell test for Parkinson by a hyperosmic spouse.

#275

A drug with no toxicity that might prevent and treat dementia in ApoE4 carriers. Very interesting indeed.

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#276

Recommended viewing by Dr. DaySpring:

Revolutionizing Brain Health: Genetics, Lipid Science, and Cutting-Edge Dementia Prevention

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#277

Yes, an excellent presentation on The Proof podcast. I knew about the ApoE connection to dementia but this illuminated how this apolipoprotein ties in with ApoB and ApoA1 and also the relationship between brain cholesterol and peripheral cholesterol. Tom Dayspring was at his best and it was a lively discussion. Fascinating subject.

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#278
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#279

Association of Adherence to a MIND-Style Diet With the Risk of Cognitive Impairment and Decline in the REGARDS Cohort

Greater MIND diet adherence was associated with decreased risk of cognitive impairment in female participants.

Paywalled Paper:

https://www.neurology.org/doi/10.1212/WNL.0000000000209817

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#280

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Typically, individuals with early-stage Alzheimer’s disease perform progressively worse on standard neuropsychological tests, losing a few points every year. But in Chan’s study, participants’ test scores have remained stable. Brain volumes have shown no signs of shrinking and levels of a disease-associated protein in the blood have even trended downwards. “These patients have conquered the test of time,” says Chan, who presented the findings at an international conference on neurodegenerative diseases

https://www.nature.com/articles/d41586-024-03147-1

More discussion on the topic:

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Brain stimulation with 40 Hz music and strobe light promotes removal of toxic amyloid via glymphatic pathways (Nature)
#281
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#282

University of Pittsburgh scientists have independently validated a new blood test platform that can simultaneously measure more than a hundred biomarkers of Alzheimer’s disease. The platform might improve clinicians’ ability to capture the multifaceted nature of Alzheimer’s pathology and streamline early disease diagnostics. The report is published in Molecular Neurodegeneration .

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#283
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#284

Neuroprotective effects of magnesium: implications for neuroinflammation and cognitive decline.

Neurodegenerative diseases, which are characterized by progressive neuronal loss and cognitive decline, are a significant concern for the aging population. Neuroinflammation, a shared characteristic of these diseases, is implicated in their pathogenesis. This article briefly summarizes the role of magnesium, an essential mineral involved in numerous enzymatic reactions and critical for neuronal bioactivity, in the context of neuroinflammation and cognitive decline. The potential neuroprotective effects of magnesium, including the mechanisms of neuroprotection by magnesium through maintaining neuronal ion homeostasis, reducing inflammation, and preventing excitotoxicity, are also described. Additionally, we discuss the impact of inadequate magnesium on neuroinflammation and its potential as a therapeutic agent for attenuating cognitive decline to improve neurodegenerative conditions.

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