The scientists don’t seem to agree with Peter Diamandis’ Longevity Escape Velocity predictions…
I tend to think Max and Matt are more knowledgeable than Peter in this area:
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Bicep
#72
I would argue more with the “general public” part of that. The general public has all kinds of problems. All cause mortality has stayed up since the pandemic.
I agree anything is possible if you work at it, but it takes generations to make a change like that, and for the general public, I doubt it will be allowed.
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I would not risk the negative effects on gut microbiome using the antibiotic for supposed value of longevity.
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Neo
#74
Seems like a lot depends on how he/one defines “general public” and “escape velocity”.
If he means that the average/median person in 6 years, as in a 35-40 years old or so at that point (so ~30-35 year old today), might have enough medical and technological advances in front of them before they succumb to death to massively extend their life (and get to the next bridge to the next bridge and so on)…
… then it does seems to me that there is some meaningful probability that that could play out
Scenarios where the next two to four decades are increasingly exponential in our ability to do learn, understand and do R&D - including scenarios where even 10% of the potential of AI is realized, could see tremendous advances at ever increasing speeds.
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Any so-called longevity method that sacrifices the gut microbiome is unacceptable, as the gut microbiome is the cornerstone of longevity for us. It is the largest immune organ in the human body, and I would not consider relying on antibiotics for so-called longevity.
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Long-term use of antibiotics can cause liver and kidney toxicity and may lead to autoimmune diseases. Many people who have taken doxycycline or minocycline for an extended period of time have developed autoimmune liver diseases. It should be noted that those who have this disease cannot expect to live a long life.
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AnUser
#77
For some reason this seems very interesting to me.
It is precisely because the current view is that the gut bacteria is very important.
This is a very contrarian intervention. Surely Peter Diamandis is familiar with the gut microbiome talk and trend. And he takes it despite it. Talk about going against the grain.
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AnUser
#78
I’ve heard it’s common in China to take antibiotics (like in a drop-in clinic with IV), for overall wellness, is this true? Not saying it’s bad or good, just curious.
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Bicep
#79
It’s possible that at this low dose weekly it improves the microbiome and reduces the microbial burden. It could act as a selective herbicide does for the farmer, to hurt the bad guys and make it a little easier for the good.
I’m not an expert at this, but it’s not the craziest thing I’ve seen. Farmers (whether right or wrong) have for years fed tetracycline because it makes the animals healthier and makes money. I don’t know if they still do, I’m not in that business any more.
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https://www.costco.com/cmpps?drugIdentifierParam=55698435705&drugNameParam=Doxycycline+Hyclate
Doxycycline, 20 mg, 60 tabs, $18.99.
Four studies reported on the effect of doxycycline on faecal microbiota, one at suboptimal dosage (20 mg for 9 months) in patients with periodontitis57 and two at usual dose 100–150 mg for 7–10 days, although one also with a probiotic,56 58 and another at low dose (40 mg for 16 weeks),59 as described in table 2. Doxycycline treatment did not significantly affect counts of total anaerobic bacteria, candida, total enterics, Staphylococcus or doxycycline-resistant bacteria recovered at any of the sample periods and did not result in the development of multi-antibiotic resistance.57 Matto et al 58 specifically evaluated the influence of doxycycline therapy on the composition and antibiotic susceptibility of intestinal Bifidobacteria in nine subjects while they were also taking a probiotic and compared these to adults consuming only probiotics. A marked decrease in diversity of Bifidobacterium populations was observed during doxycycline therapy. Tetracycline-resistant Bifidobacterium isolates were more commonly detected in the antibiotic group than in the control group, thus increasing the pool of resistant commensal bacteria in the intestine.
In summary, doxycycline interferes with a microorganism’s ability to manufacture proteins. At suboptimal dosage (20 mg per day), it has little effect on the gut microbiota with the exception of enterococci and E. coli .
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peterc
#81
Yes, at 20mg it seems to be an AINO (Antibiotic In Name Only) and would seem to be safe even long-term.
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@Agetron you still doing Doxycycline 200mg with your Rapa dose 100 day and 100 night or all together? I am going to do this too since I now have a bionic hip. Figure it should negate the risks of rogue bacteria inhabiting my prosthesis.
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drfawn
#83
Changes in Gut Microbiota Induced by Doxycycline …
by I Robles-Vera · 2021 · Cited by 6 — Doxycycline Treatment Improved Intestinal Integrity, Colonic Inflammation and Reduced Endotoxemia and Plasma Noradrenaline in DOCA-Salt Rats.
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Yes, I still take 200 mg on the day of my rapamycin dose.Yes, a 100 mg pill in morning and 100 mg at bedtime.
Pretty healthy… skin heals rapidly when injured. Open cut to gone in 5-7 days.
Leonard
#85
If you at this subclinical dose can see an increase in doxy-resistant bacteria and a decrease in friendly bífidus bacteria, I think it bodes bad for chronicle use at therapeutic dosage. It’s prescribed for youngster with severe Acne, but I don’t see it as proof for that it’s without side effects. Maximal treatment length against acne should be 3-4 months because the risk of developing resistente bacteria.
Doctors are probably prescribing doxy quite frivolously, because there already are a lot of of resistant bacteria circulating, knowing that they have heavier (as still effective broad spectrum) weapons in their arsenal.
I for sure know that i won’t volunteer to become a vessel for growing these resistente bacteria in my gut.
But each to their own. 
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I have been on the 6mg Rapa plus 100mg Doxcycline regime for about 4 months (almost immediately once I learnt about this).
The reason I was so quick to jump on this was twofold (I also have MS):
- Doxycycline Treatment for Multiple Sclerosis
Synopsis: Addition of doxycycline to interferon-beta therapy in patients with relapsing-remitting multiple sclerosis might improve control of inflammatory lesions.
- Rapamycin Plus Doxycycline Combination Affects Growth Arrest and Selective Autophagy-Dependent Cell Death in Breast Cancer Cells
The rapamycin + doxycycline combination decreased tumour proliferation in about 2/3rd of the investigated cell lines. The continuous treatment reduced tumour growth significantly both in vivo and in vitro.
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I should have thought of this sooner. About a third of my femur plus my entire knee are mostly stainless steel (I had chondrosarcoma) and a big concern is infection which - if it gets to the implant - is Very Bad.
Thanks for the insight!
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Jim
#88
Affordable Rifaximin/Rapamycin, Rybelsus,SIBO Discussions
Point by point analysis by Richard.
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It sounds like he’s dropped the doxycycline he was taking with rapamycin.
I also found this interesting:
And his current protocol:
Longevity Practices_27Nov23.pdf (658.2 KB)
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