Peter Attia article on Pentadecanoic Acid (C15:0) aka Fatty15

[helenas]

@CronosTempi

I used to be a big Peter Attia fan, but have pulled back a bit. I don’t think he’s a hustler like Huberman, or borderline conman like David Sinclair. But I find his analysis often surprisingly sloppy (given his devotion to the scientific method), and various sudden enthusiasms frequently unwarranted. He’s surprisingly vulnerable to woo, often having guests on who espouse various spiritual/emotional/life-wisdom nostrums which are just fads of the moment with no real science behind it. He latches on to fads far too quickly and with too little examination of the evidence (that’s where the keto and fasting fall, and now his absurd advocacy for the overconsumption of venison protein, etc., endlessly). I find it tedious, and only listen when he has genuine researchers on, which is increasingly rare - and while he was never a particularly fabulous interviewer, he’s gotten worse, loves to hear himself talk, the questions crowd out the answers, and gets lost in tangents unable to get back to the original point. I now listen to his podcast once every few weeks, depending on whom he gets.

I told my friends before, the inevitable destiny of health (and in general all) influencers is that what started as a niche, hyper-focused, specialized content distribution goal will always become subordinate to market forces when money, marketing, and mass public involvement come into play. In order to maintain listeners, attract new ones, AND continue to produce new content, they need to continue finding new avenues to bait people’s attention, with new ideas, new results. Every new piece of information needs to be sold as relevant for discussion, lest: Attia just talks about cholesterol for the rest of his career, Rhonda Patrick talks about Vitamin D and omega-3’s the rest of her career, and Huberman the neuroscience of vision for the rest of his career, and Sinclair…

And thus the actual result of all of them is: a big circle jerk. What I mean by that is not necessarily derogatory, but rather that you eventually you see them all converge on interviewing the same group of people, who cycle back and forth between each other’s podcasts in what is basically a circular fashion. Patrick interviewing Huberman interviewing Attia interviewing Huberman interviewing Patrick and so on and so forth. They run out of people to interview, and it becomes the rare occasion to see someone new that people have not heard about before who has an actual different insight into the field.

[mccoy]

@Joseph_Lavelle

Check this thread.

thanks, heard about it a couple of times in presentations but here it’s still all but unknown.

[Mantheunknown]

Hello, I buy Pitavastatin in India all the time (for nearly 8 years). I take Pivasta, but have tried other local brands depending on availability. I purchase 4 or 2 mg tablets and break them in half as required at that point in time.
Cheers

[Joseph_Leon]

I love Peter Attia, but I’m not sure I approve of his method of disclosing relationships with products. For instance, he lists Oura as a company he “invests” in. But that is not accurate if he is just getting shares in Oura for promotional work. Investing in a company means using one’s own money and implies some belief in the company. Accepting shares for promoting the company is just the same as paid promotion.

[Joseph_Leon]

I agree you read it wrong.

This study utilized Eurofins BioMAP Diversity PLUS assay system to test C15:0 and more established longevity molecules (rapamycin, metformin, and acarbose, all discussed with Rich Miller in [episode #281])

It’s a parenthetical listing the the more established longevity molecules he discussed with Rich Miller.

[Joseph_Leon]

Very interesting!

Can you give me some more info on FMD and 24 hour fasting around rapamycin ingestion? I don’t want to buy the crappy FMD products with all their additives and bad ingredients. Do you make your own FMD food?

[AnUser]

! New Episode: Is C:15 an Essential Fat? Science vs. Hype C:15 (pentadecanoic acid) is being promoted as a new essential nutrient, a longevity booster, and a game-changer for metabolic health—but what does the science actually say? Watch now: Dr. Bill Harris, a leading fatty acid researcher, joins me to break down the claims surrounding C:15 and whether supplementation is truly necessary. Key topics covered: - What exactly is C:15, and how does it compare to other fatty acids? - Does the evidence support C:15 as an essential nutrient? - What do clinical trials actually show about its effects on cholesterol and metabolic health? - The controversy around patents on naturally occurring fats

Fatty15: The New Longevity Nutrient? | Bill Harris | The Proof

[Dr.Bart]

Personally I love Pecorino cheese grated on dishes or slices of Manchego in a sandwich. Goat cheeses are supposed to be great sources of pentadecanoic acid, so best case scenario it helps longevity, worst case scenario I am getting extra protein. These would be my only sources of saturated fat other occasional butter, so still keeping easily under 10 grams a day… and only small fraction of all saturated fats are actually harmful.

[relaxedmeatball]

@Joseph_Lavelle

He is too aggressive and quick to high confidence for me.

I realise your post is a little bit old now, but I disagree with you. In those cases of keto, fasting or statins, I think it was quite brave of Attia to do them, stick to them, and then drop them when the evidence or experience turned the other way. As you know, people get a bit religious about this stuff, and if you’ve built a large part of your identity around being “a keto guy”, then it’s very uncomfortable to admit you were maybe wrong and start eating pasta again. A lot of people got angry at Attia for “betraying” their ideology.

I don’t think he was certain or gave conclusive remarks either way for any of them.

@CronosTempi

I used to be a big Peter Attia fan, but have pulled back a bit. I don’t think he’s a hustler like Huberman, or borderline conman like David Sinclair. But I find his analysis often surprisingly sloppy (given his devotion to the scientific method), and various sudden enthusiasms frequently unwarranted. He’s surprisingly vulnerable to woo, often having guests on who espouse various spiritual/emotional/life-wisdom nostrums which are just fads of the moment with no real science behind it. He latches on to fads far too quickly and with too little examination of the evidence (that’s where the keto and fasting fall, and now his absurd advocacy for the overconsumption of venison protein, etc., endlessly). I find it tedious, and only listen when he has genuine researchers on, which is increasingly rare - and while he was never a particularly fabulous interviewer, he’s gotten worse, loves to hear himself talk, the questions crowd out the answers, and gets lost in tangents unable to get back to the original point. I now listen to his podcast once every few weeks, depending on whom he gets.

I partly agree with this. He does talk way too much now. Often more than the guests. And often he seems to cut people off right as they were getting to the crux of whatever it was they were trying to say.

Though I don’t agree with you about him embracing fads. I’d say he’s pretty cautious overall, but he also knows that some things are likely worth trying.

He also has a few crappy guests. The recent one with Mike Israetel was pretty cringeworthy IMO. I honestly don’t think Mike is an expert in very much, and the dude is barely a scientist IMO. He did a PhD, but he’s had teaching and coaching gigs. The podcast was supposedly about science of hypertrophy, but at no point did they actually talk about the science of hypertrophy, or any of the evidence for rep ranges, RER/RIR, % of 1RM training. It was just Israetel spouting off loads of bro facts which weren’t challenged at all by Attia. Stuff about muscle damage, tension etc wasn’t scientific at all.

It would have been much better to have Eric Trexler, or Greg Nuckols who are actual experts and could talk about the science.

[Joseph_Lavelle]

@relaxedmeatball

I don’t think he was certain or gave conclusive remarks either way for any of them.

Your comments are quite reasonable except for this one. With regard to keto, you are entirely mistaken. He co-founded a research company and raised millions to deliver medical proof of the superiority of keto. Admittedly he quit the company once the proof wasn’t forthcoming but at first he claimed the test was not well done as an explanation. It took him many years to give it up. Now he hates to talk about nutrition.

I also will not forget the Oura ring deception. I laugh whenever he claims to be transparent about sponsorship. Fool me once shame on you, fool me twice shame on me.

Attia has good guest so I listen sometimes.

You have a right to your opinion.

[relaxedmeatball]

@Joseph_Lavelle

Your comments are quite reasonable except for this one. With regard to keto, you are entirely mistaken.

Interesting! I only listen to the podcast, and I don’t follow Instagram or anything else. Is that how you’re hearing about these things? I’ve listed since maybe the 30th episode and don’t really know anything about Oura ring or a keto company. I do recall him mentioning trying to do a study about keto, and I remember when he said he’d stopped doing it.

I also vaguely knew that he sued Oura last year. Based on your comment I’ve just looked into it and read a few news articles and a god-awful reddit thread, but I still don’t really see what he has done wrong. He said many many times on the podcast that he was an advisor and is getting paid by them. That by itself isn’t wrong, I don’t think. And he never really pushed their product or told listeners to get Oura rings.

[Joseph_Lavelle]

@relaxedmeatball

I still don’t really see what he has done wrong

I’ve been following Attia since about 2016 (pre-podcast). He burned his bridge with me. Perhaps he has learned his lessons and is reformed. Good for him. I don’t trust him nor do I want to know what he thinks about anything. I do listen to his guests, though.

[Beth]

I can’t remember the specifics at this point, so take this with a grain of salt…

I remember watching and noticed he was no longer wearing his oura, and around the same time he was touting that another tracker was far superior. I have no doubt about that being true and there is nothing wrong about doing that on face value.

But then, soon afterwards, I read about the lawsuit with oura… it smelled funny to me and I no longer trusted him as much.

Earlier it happened with olive oil. He raved about one brand and said I have no affiliation … and then I bought it… next thing I knew, he had an affiliation.

Less offensive to me was when he was saying he doesn’t like protein bars and made a big deal about it. Several months later, he introduced his own… they were obviously already underway.

Then all the podcast bros were talking about the jerky he sells.

None of this was technically unethical, but I’ve seen enough to realize he is much more money motivated than he appears to be.

I still value his advice and feel he has a lot to offer, but I now look at him as a guy trying to cash in, so I am cautious about what he teaches and wonder if it’s a setup to create a market for himself.

For clarity, I have zero problem with anyone cashing in. I’m a capitalist and he’s good and deserves to be rich, I just don’t want to feel tricked.